Search Results - nicholas+stephanopoulos

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Resting-State Functional Magnetic Resonance Imaging Derived From Dynamic Perfusion Imaging (Case No. 2023-126)
Intro Sentence: UCLA researchers in the Department of Radiology have developed a novel method for obtaining simultaneous perfusion and functional MRI data from a single MRI acquisition to improve the diagnosis, monitoring, and management of brain tumors and stroke. Background: Advanced magnetic resonance imaging (MRI) techniques are crucial for...
Published: 10/23/2024   |   Inventor(s): Benjamin Ellingson, Nicholas Cho, Chencai Wang
Keywords(s):  
Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Medical Devices > Monitoring And Recording Systems
Nanotechnology Platform for Identification of Ligand Binding Sites on a Protein
The ability to identify target ligand binding sites on a protein surface is of great importance to drug design, discovery and screening, as well as general and bionanotechnology research. Protein-ligand interactions allow for a complex network of molecular interactions. While it is possible to experimentally screen large amounts of binders, computational...
Published: 5/17/2023   |   Inventor(s): Petr Sulc, Nicholas Stephanopoulos
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs)
Synthesis of DNA-Peptide-DNA Triblock Molecules
­Hybrid oligonucleotide-peptide compositions have many applications including DNA and RNA delivery, dynamic biomaterials, and hybrid self-assembling nanomaterials. The different components impart different activities; the peptide can be used for cell targeting, endosomal escape, cell surface receptor engagement, or enzymatic responsiveness, while...
Published: 2/23/2023   |   Inventor(s): Nicholas Stephanopoulos, Tara MacCulloch
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Chemical/Biological Sensors, Life Science (All LS Techs), Pharmaceuticals, Proteomic Assays/Reagents/Tools, Genomic Assays/Reagents/Tools
Reconfigurable DNA Nano-Tweezer
Nanotechnology has grown by leaps and bounds in the past few decades. One of the main goals of nanotechnology is to build machines, switches or devices at the subatomic level that operate in a stimulus-responsive manner. Because DNA, via Watson-Crick pairing, is so precisely programmable, it is an ideal building block for creating such systems. In fact,...
Published: 2/23/2023   |   Inventor(s): Nicholas Stephanopoulos, Minghui Liu
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Biomaterials, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Pharmaceuticals, Proteomic Assays/Reagents/Tools
Tunable Nanoscale Hybrid Cages
The programmable nature and vast utility of three-dimensional cages makes them an important target for nanotechnology. While proteins and DNA have both been used as building blocks to create tunable nanoscale cages, each molecular type has its own limitations. Tuning nanoscale parameters in protein nanocages typically requires the entire system to be...
Published: 2/23/2023   |   Inventor(s): Nicholas Stephanopoulos, Yang Xu
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Medical Imaging, Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 2/23/2023   |   Inventor(s): Alexander Green, Matthew Gilliam, Kirstie Swingle, Nicholas Stephanopoulos, Neal Woodbury
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors