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Search Results - lina+cui
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Clonal Spodoptera Frugiperda Cell lines for Enhanced Expression
This technology includes Spodoptera frugiperda (Sf9) cells which were developed to produce recombinant adeno-associated virus. The cells maintain a copy of the vector genome and for production, require infection with a single baculovirus that expresses either structural and nonstructural proteins to produce rAAV, or the non-structural (Rep) proteins...
Published: 8/12/2024
|
Inventor(s):
Lina Li
,
Robert Kotin
Keywords(s):
Category(s):
Application > Research Materials
,
Application > Therapeutics
,
Collaboration Sought > Licensing
,
ResearchProducts > Plasmids/Vectors
Capsid-Free AAV Vectors for Gene Delivery and Their Use for Gene Therapy
The invention concerns novel capsid-free AAV vectors that can be used for gene delivery and gene therapy applications. The invention provides for a linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest, and a second AAV ITR, wherein said nucleic acid...
Published: 7/25/2024
|
Inventor(s):
Lina Li
,
Luis Garcia
,
Cyriaque Beley
,
Thomas Voit
,
Robert Kotin
Keywords(s):
AAV
,
Cell
,
Clonal
,
Containing
,
DNA
,
GB2AXX
,
Lines
,
Listed LPM Reichman as of 4/15/2015
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
Rescueable
,
Sf9
,
STABLE
,
Vector
,
VPXXXX
,
WJXXXX
,
XEXXXX
,
YAXXXX
,
YBXXXX
Category(s):
Collaboration Sought > Licensing
,
TherapeuticArea > Dental
,
TherapeuticArea > Endocrinology
,
Application > Therapeutics
,
TherapeuticArea > Ophthalmology
,
TherapeuticArea > Oncology
,
TherapeuticArea > Cardiology
,
TherapeuticArea > Infectious Disease
Self-neutralizing air-breathing thruster and method of neutralization
An ion-engine is the cutting edge for atmospheric air-breathing engines. The technology depends on ionizing and neutralizing atmospheric air particles which create thrust. This unique possibility makes it an ideal choice for very-low-orbit satellites. Very- low-orbit satellite capabilities have benefits such as higher resolution for images, weight...
Published: 7/30/2024
|
Inventor(s):
Michael Keidar
,
Anmol Taploo
,
Li Lin
Keywords(s):
Category(s):
Technology Classifications > Computers Electronics & Software
,
Technology Classifications > Computers Electronics & Software > Aviation
,
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
,
Technology Classifications > Industrial or Consumer Tech > Industrial Manufacturing
Non-Invasive Plasma Discharge Tube Device for Treating Brain Tumors
Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very effective in treating recurring tumors, and have significant clinical toxicity. A novel Plasma Discharge Tube (PDT) device has the potential to be more effective and less...
Published: 7/30/2024
|
Inventor(s):
Michael Keidar
,
Li Lin
,
Vikas Soni
,
Xiaoliang Yao
,
Dayun Yan
,
Jonathan Sherman
Keywords(s):
Category(s):
Technology Classifications > Medical Devices
,
Technology Classifications > Medical Devices > Surgical
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024
|
Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Cold atmospheric plasma-stimulated media for treating cancers
For successful cancer therapy, the most important aspect is selective eradication of cancer cells without damaging healthy cells. Cancer cells and normal cells have different thresholds for tolerance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) before cell death (apoptosis) is induced. Previously, GW researchers invented a cold...
Published: 7/30/2024
|
Inventor(s):
Michael Keidar
,
Zhitong Chen
,
Xiaoqian Cheng
,
Li Lin
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Cells
,
Technology Classifications > Therapeutics
Ultrasensitive Fluorogenic Probe to Detect Heparanase Activity
Single-Step Fluorescence Assay Facilitates High-Throughput Screening of Heparanase Inhibitors This fluorogenic probe tests for the presence of heparanase and facilitates rapid screening for heparanase inhibitors to aid the development of cancer therapeutics. Heparanase is an enzyme overexpressed in many carcinomas, sarcomas, hematological malignancies,...
Published: 11/19/2021
|
Inventor(s):
Lina Cui
,
Jun Liu
,
Kelton Schleyer
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
Fluorogenic Probe for More Precise Detection of Cathepsin L Activity
Demonstrates Good Selectivity and High Sensitivity for the Protease Within 10 Minutes This fluorogenic probe rapidly detects cathepsin L activity with high sensitivity and selectivity. Cathepsin L is a lysosomal protease upregulated in many diseases and forms of cancer. Proteases are involved in the development and progression of cancer; inhibiting...
Published: 8/25/2021
|
Inventor(s):
Lina Cui
,
Kelton Schleyer
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
,
Technology Classifications > Human Health Care > Diagnostics
Plod3-Targeted Anti-Cancer Treatment
UCLA Case No. 2019-281 Summary UCLA researchers in the department of Dentistry have developed a novel anti-cancer treatment that directly targets enzyme expression necessary to sustain cancer growth. Background The incidences of cancer diagnosis in the United States is reported to grow continually in the next decade. While there are a growing...
Published: 7/19/2023
|
Inventor(s):
Shen Hu
,
Li Cui
Keywords(s):
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Plasmids/Vectors
,
Platforms > Diagnostic Platform Technologies
,
Therapeutics > Oncology
Twistron Mechanical Energy Harvesters
Mechanical energy harvesters are needed for diverse applications, including self-powered wireless sensors, structural and human health monitoring systems, automotive technologies, and the extraction of energy from ocean waves. Until now, few harvesters have been flexible enough to be used as yarns in textiles, and the performance of such yarns has been...
Published: 6/26/2024
|
Inventor(s):
Shi Hyeong Kim
,
Carter Haines
,
Na Li
,
Keon Jung Kim
,
Tae Jin Mun
,
Changsoon Choi
,
Jiangtao Di
,
Shaoli Fang
,
Seon Jeong Kim
,
Ray Baughman
Keywords(s):
Automotive
,
Carbon Nanomaterials
,
Carbon Nanotubes
,
Electronics
,
Energy, Cleantech & Environmental
,
Engineering & Physical Sciences
,
Renewable Energy
,
Sensors & Controls
,
Textiles
,
Wireless
Category(s):
Nanotechnology
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