Search Results - life+sciences+%3e+biomarkers+%26+biomedical+research+tools

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Complement detection and inhibition improves lung transplant outcomes
NU 2023-199 INVENTORS Ankit Bharat* BACKGROUND Lung transplants can often lead to dreaded complications shortly after transplantation. For example, the potentially lethal syndrome Primary Graft Dysfunction (PGD) manifests in more than 50% of recipients within the initial 72 hours after implantation and can lead to both short- and long-term...
Published: 11/13/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Inflammation sensitive bacteria can detect flares of IBD
NU 2023-131 INVENTORS Jonathan Xia Arthur Prindle* BACKGROUND The prevalence of Inflammatory Bowel Disease (IBD), a spectrum of chronic autoimmune inflammatory disorders of the gastrointestinal tract, has steadily increased from 3.7 million in 1990 to 6.8 million in 2017. The spectrum of diseases are characterized by a relapsing and remitting...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
ASOs targeted towards mis-spliced UNC13A
NU2022-200 INVENTORS Wanhao Chi Jonathan Watts Evangelos Kiskinis* BACKGROUND Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative that leads to 1 in 500 deaths in adults. There is no cure to stop or reverse ALS, thus there is a need to better understand its pathobiology and develop effective therapeutics. Northwestern...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Membrane Encapsulation of a Transcriptionally Regulated Cell-Free Biosensor
NU 2022-162 INVENTORS Neha P. Kamat* Julius B. Lucks* Margrethe Boyd Walter M. Thavarajah BACKGROUND Cell-free systems allow biochemical processes traditionally performed by cells to be reproduced independent of cells in a cost-effective, distributable, and highly tunable manner. Specifically, cell-free biosensors have enabled...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes
NU 2022-192 INVENTORS Neha P. Kamat* Vivian Hu BACKGROUND Virus infection posts a recurring global health challenge, and vaccines remain an effective protective against virus threats. However, many current vaccines face limitations including potential conversion of inactivated virus into pathogenic virus, immunogenicity of recombinant...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
A Protein Fusion Approach for Cell Free Production and Purification of Tagless Therapeutic Hormones
NU 2021-182 INVENTORS Michael C. Jewett* Ariel N. Thames Madison A. DeWinter Weston K. Kightlinger BACKGROUND Sensitive biologic medicines can be difficult to safely deliver due to cold chain and infrastructure constraints. Point-of-care drug manufacturing could circumvent these challenges since medicines could be produced locally and...
Published: 12/9/2024   |   Inventor(s):  
Keywords(s): Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Location-specific growth media for brain tumor organoids
LU 2023-082 INVENTORS Xiaonan Li* Milagros Suarez Palacios Yuchen Du SHORT DESCRIPTION Location-matched growth media formulations in brain tumor organoid models for biological and therapeutic applications BACKGROUND Brain cancer is the second most common type of childhood malignancy and the leading cause of death in children. Despite recent...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Antibody for Diagnosis of Kawasaki Disease
NU 2018-214 NU 2022-027 INVENTORS Anne Rowley* Stanford Shulman Susan Baker SHORT DESCRIPTION Monoclonal antibodies, produced from Kawasaki disease plasmablasts, whose binding interactions provides a biomarker for disease diagnosis. BACKGROUND Kawasaki disease (KD) manifests as an acute febrile condition in children, exhibiting clinical features...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Novel Biomarker for Lung Disease Diagnosis and Monitoring
NU2022-232 INVENTORS Ankit Bharat* Yuanqing Yan SHORT DESCRIPTION A robust and reliable biomarker for diagnosing and predicting lung disease ABSTRACT The lack of robust biomarkers for lung diseases is a pressing challenge. A team of scientists at Northwestern University has identified the protein serine protease inhibitor Kazal-type 1 (SPINK1)...
Published: 12/23/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Analytical Device for Sorting Single Cells Based on Secreted Products
NU 2023-084 INVENTORS Shana O. Kelley* Zongjie Wang Mahmoud A. M. Labib SHORT DESCRIPTION A high-throughput, cost-effective device for sorting of single cells in a culture and analysis of their secreted products. BACKGROUND The demand for cost-effective cell analysis methods is expanding due to the increasing urge for the early detection,...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s): Autoimmune disease, Biomedical, Devices, Diagnostics, Drug screening, Personalized medicine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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