Search Results - life+sciences+%3e+biomarkers+%26+biomedical+research+tools

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Using human iPSC-derived bone marrow organoids to model human bone marrow diseases ex vivo
NU 2024-129 INVENTORS Peng Ji* Ermin Li Kehan Ren SHORT DESCRIPTION Methods and factors for engrafting a bone marrow organoid with CD34+ hematopoietic stem and progenitor cells BACKGROUND Translational research for hematological diseases often relies on engrafting hematopoietic stem and progenitor cells (HSPCs) into immunodeficient mouse...
Published: 4/9/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Rapid Nanomechanical Diagnostic Assay for SARS-CoV-2 and Other Pulmonary Diseases Detection
NU 2021-142 INVENTORS Gajendra Shekhawat* Vinayak Dravid SHORT DESCRIPTION This invention introduces a nanomechanical diagnostic assay leveraging microcantilevers for the rapid and specific detection of SARS-CoV-2 antigens, achieving results in under 10 minutes with high sensitivity and selectivity. BACKGROUND Rapid detection of respiratory...
Published: 3/2/2025   |   Inventor(s):  
Keywords(s): COVID-19, Diagnostics, Pulmonary disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Two-component system for Biosensing
NU 2023-043 INVENTORS Neha Kamat* Justin Alexander Peruzzi SHORT DESCRIPTION This technology leverages bacterial two-component systems to enable transmembrane signal transduction in synthetic membranes, offering a novel platform for biosensing and therapeutic applications. BACKGROUND Signal transduction across cellular membranes is...
Published: 2/28/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Functionalized lipid nanoparticles
NU 2022-184 INVENTORS Neha Kamat* Justin Alexander Peruzzi* Timothy Vu* SHORT DESCRIPTION This technology facilitates the rapid expression and conjugation of therapeutic proteins to nanoparticles, creating highly specific drug delivery systems that can be generated swiftly and cost-effectively. BACKGROUND In recent years, there...
Published: 2/28/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Engineered Lipid Tags for Extracellular Vesicle Loading
NU 2022-178 INVENTORS Neha Kamat* Joshua Leonard* Justin Alexander Peruzzi Taylor Gunnels SHORT DESCRIPTION This technology enhances the loading of protein cargo into extracellular vesicles (EVs) by directing protein association with membrane lipid rafts, utilizing engineered lipid tags for targeted delivery. BACKGROUND Extracellular...
Published: 2/28/2025   |   Inventor(s):  
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Leveraging Lipid-Protein Interactions to Engineer Spatial Organization in Cell-free Systems
NU 2021-231 INVENTORS Neha Kamat* Justin Alexander Peruzzi Jan Steinkuehler SHORT DESCRIPTION This innovative method enables the control of membrane protein location and distribution in synthetic lipid membranes using lipid-protein interactions, without chemical conjugation, facilitating the development of advanced cell-free systems. BACKGROUND Spatially...
Published: 2/28/2025   |   Inventor(s):  
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Physical Sciences > Engineering & Technology
CRISPR-Mediated Cleavage of Enzyme-Oligonucleotide Conjugates for Detection of Target Analytes
CRISPR-Mediated Cleavage of Enzyme-Oligonucleotide Conjugates for Detection of Target Analytes NU 2021-068 INVENTORS Chad Mirkin* Devleena Samanta Sasha Ebrahimi SHORT DESCRIPTION This technology leverages CRISPR-mediated cleavage of enzyme-oligonucleotide conjugates to enable sensitive, colorimetric detection of target analytes without the...
Published: 3/3/2025   |   Inventor(s):  
Keywords(s): COVID-19, Diagnostics, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
A synthetic poly-transthyretin affinity trap for diagnosing transthyretin amyloidosis
NU 2021-066 INVENTOR Jing Jin* SHORT DESCRIPTION This invention introduces a novel inducible transthyretin monomer trap that selectively binds and measures amyloidogenic TTR monomers. This assay offers a potential clinical tool for diagnosing transthyretin amyloidosis in plasma from patients. BACKGROUND Transthyretin amyloidosis (ATTR) is...
Published: 2/7/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Model of the Human Endometrium
NU 2020-166 INVENTORS John Kessler* Virginia Cheung Chian-Yu Peng SHORT DESCRIPTION Methods and compositions to generate a multicellular model of the human endometrium by differentiating pluripotent stem cells into endometrial stromal fibroblasts and co-culturing with placenta-derived endometrial epithelial organoids, with applications in drug...
Published: 2/5/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Genetic circuits for engineering hypoxia-responsive cellular functions
NU 2021-259 INVENTORS Joshua Leonard* Patrick Donahue SHORT DESCRIPTION A customizable DNA based biosensor for detecting hypoxic environments BACKGROUND Cell-based therapies have been successful in treating many malignancies, leading to substantial increases in patient survival. However, translating these successes to the treatment of solid...
Published: 3/3/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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