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Spherical Nucleic Acids with Sheddable PEG Layers
Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications,...
Published: 10/30/2025   |   Inventor(s):  
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Synthetic Peptide Antigens to Detect Anti-Nephrin Autoantibodies
NU2025-147 Inventors Jing Jin* Pan Liu Short Description The invention provides a method for detecting anti-nephrin autoantibodies implicated in kidney diseases like minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). This method employs synthetic peptide antigens for use as a clinical diagnostic. Background Kidney...
Published: 10/28/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Identification of Atrial Fibrillation Progression via Integrated Electrogram and Imaging Analysis
NU 2023-222 INVENTORS Markus Rottmann* SHORT DESCRIPTION This invention integrates advanced analysis of atrial fibrillation electrograms and T1/T2 imaging to identify the progression state of AF. It offers clinicians a predictive tool to tailor treatment strategies and improve patient management. BACKGROUND Atrial fibrillation shows distinct...
Published: 10/28/2025   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Nanocytological and Molecular Analysis of Fecal Colonocytes for Colon Cancer Screening
NU 2010-131 INVENTORS Vadim Backman* Dhwanil Damania Dhananjay Kunte Hariharan Subramanian Hemant Roy Mart De La Cruz SHORT DESCRIPTION This technology offers a novel fecal test that detects nanoarchitectural and molecular markers in colonocytes. It delivers a minimally invasive screening method for early detection of colon cancer. BACKGROUND Colorectal...
Published: 10/10/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Colon cancer, Diagnostics, Drug screening, Imaging, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
iPSCs derived from endometriosis and PCOS patients
NU 2025-155 INVENTORS Ji-Yong Kim* Teresa Woodruff SHORT DESCRIPTION Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) of women diagnosed with endometriosis or polycystic ovary syndrome (PCOS). BACKGROUND Endometriosis and PCOS are complex, multifactorial reproductive disorders that affect...
Published: 10/9/2025   |   Inventor(s):  
Keywords(s): Cell Line, Drug screening, Obstetric/Gynecological, Stem cell
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Magnetic Resonance Contrast Agents for the Detection and Imaging of Senescence
NU 2024-024 INVENTORS Thomas Meade* Heike Daldrup-Link SHORT DESCRIPTION An MRI probe to detect senescent cells in vivo and in real-time. BACKGROUND Senescent cells promote osteoarthritis progression and are also found in cancer, virus infection, and other disease states. However, there is a lack of diagnostic tool to detect...
Published: 10/3/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons
Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons NU 2018-157 Peptide amphiphile nanofibers enhance neuron maturation by promoting high mobility while reducing cell aggregation. INVENTORS Samuel I. Stupp Zaida Alvarez Pinto Juan Alberto Ortega Cano Kohei Sato Evangelos Kiskinis SHORT DESCRIPTION A...
Published: 10/3/2025   |   Inventor(s):  
Keywords(s): Neurology, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Using human iPSC-derived bone marrow organoids to model human bone marrow diseases ex vivo
NU 2024-129 INVENTORS Peng Ji* Ermin Li Kehan Ren SHORT DESCRIPTION Methods and factors for engrafting a bone marrow organoid with CD34+ hematopoietic stem and progenitor cells BACKGROUND Translational research for hematological diseases often relies on engrafting hematopoietic stem and progenitor cells (HSPCs) into immunodeficient mouse...
Published: 10/3/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Rapid Nanomechanical Diagnostic Assay for SARS-CoV-2 and Other Pulmonary Diseases Detection
NU 2021-142 INVENTORS Gajendra Shekhawat* Vinayak Dravid SHORT DESCRIPTION This invention introduces a nanomechanical diagnostic assay leveraging microcantilevers for the rapid and specific detection of SARS-CoV-2 antigens, achieving results in under 10 minutes with high sensitivity and selectivity. BACKGROUND Rapid detection of respiratory...
Published: 10/3/2025   |   Inventor(s):  
Keywords(s): COVID-19, Diagnostics, Pulmonary disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Two-component system for Biosensing
NU 2023-043 INVENTORS Neha Kamat* Justin Alexander Peruzzi SHORT DESCRIPTION This technology leverages bacterial two-component systems to enable transmembrane signal transduction in synthetic membranes, offering a novel platform for biosensing and therapeutic applications. BACKGROUND Signal transduction across cellular membranes is...
Published: 10/3/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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