Search Results - life+science+research+tools+%3e+plasmids%2fvectors

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Methods for Building RNA Organelles in Vitro (UCLA Case No. 2023-286)
UCLA researchers from the Department of Bioengineering have developed artificial RNA sequences that can form condensates in vitro, allowing customization of cellular function in membrane-less organelles. BACKGROUND: RNA condensates are intracellular membrane-less compartments formed by phase separation, involving RNA and proteins. These RNA condensates...
Published: 7/17/2025   |   Inventor(s): Elisa Franco
Keywords(s): Nanotechnology, RNA, synthetic biology
Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Plasmids/Vectors
Gene Therapy for DOCK8 Deficiency (UCLA Case No. 2023-178)
UCLA researchers in the Department of Pediatrics Allergy and Immunology have developed a gene therapy method to express the full-length DOCK8 protein in cells, aimed at treating DOCK8 deficiency. These method allows for safe and effective DOCK8 expression in hematopoietic stem cells without the need for an HLA-matched donor, enabling patients to undergo...
Published: 7/17/2025   |   Inventor(s): Caroline Kuo
Keywords(s): bone marrow, bone marrow transplants, DOCK8, DOCK8 deficiency, Gene Editing Systems, Gene Therapy, hematopoietic stem cells, Immune System, immunodeficiency, Immunology, intein splicing
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Life Science Research Tools > Plasmids/Vectors
Optimized Lentiviral Vector for Stem Cell Gene Therapy of Hemoglobinopathies
UCLA Case No. 2017-460 Summary UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. Background Sickle...
Published: 7/17/2025   |   Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan
Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems
Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing
2019-863 METHODS CONCERNING ONGOING TREATMENT FOR CANCER
UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel biomarker detection method for circulating blood cell-free RNA. BACKGROUND: Approximately 39% of men and women will be diagnosed with cancer at some point during their lifetimes. Circulating tumor cell-free DNA (cfDNA) is being increasingly used...
Published: 7/31/2025   |   Inventor(s): Matteo Pellegrini, Eri Srivatsan
Keywords(s): Diagnostic Markers & Platforms, Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Oncology
Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Diagnostic Markers, Platforms > Drug Delivery > Nucleic Acids
A Codon-Optimized Lentiviral Vector For Stem Cell Reprogramming (UCLA Case No. 2014-014)
A Codon-Optimized Lentiviral Vector For Stem Cell ReprogrammingSUMMARYUCLA researchers in the Department of Medicine and the Department of Surgery have developed a novel lentiviral vector that expresses a codon-optimized sequence of a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1 as well as a positron emission tomography (PET)...
Published: 7/31/2025   |   Inventor(s): Antoni Ribas, Richard Koya, Thinle Chodon
Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Immunotherapy, iPS/stem cells, Life Science Research Tools, Plasmids / Vectors, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
2018-862 GENERATION OF MINIMAL ENHANCER ELEMENTS USING MASSIVELY PARALLEL REPORTER ASSAYS
SummaryUCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin.BackgroundSickle cell disease (SCD) is one of the...
Published: 7/17/2025   |   Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan, Aaron Cooper
Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems
Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing