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Search Results - lee+johnson
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Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)
Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...
Published: 11/15/2024
|
Inventor(s):
Owen Witte
,
Zhiyuan Mao
,
Jami Witte
,
Pavlo Nesterenko
,
John Lee
Keywords(s):
Cancer
,
cancer antigen
,
Peptide
,
peptides
,
prostate cancer
,
protein
,
t-cells
Category(s):
Therapeutics
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Hybrid MOD-Enmat Lens
Researchers at the University of Arizona have designed an optical device comprising a multiple-order diffractive Fresnel lens (MOD-DFL) and an achromatizing compensation mechanism that reduces refractive dispersion created by the MOD-DFL, thereby reducing the focal range of the MOD-DFL. A method is also provided of using the optical device in an image...
Published: 6/9/2023
|
Inventor(s):
Thomas Milster
,
Lee Johnson
,
Daniel Apai
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Lens & System Design
Space Deployable Spectrometer with Large Collection Area
This invention is a highly scalable optical design that will allow the construction of deployable space telescopes with collecting areas that are an order of magnitude greater than the current state-of-the-art and with greatly reduced production and launch costs. The design includes a novel spectrometer capable of surveying transiting earth-sized exoplanets...
Published: 4/3/2023
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Inventor(s):
Thomas Milster
,
Daniel Apai
,
Lee Johnson
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics > Lens & System Design
,
Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
,
Technology Classifications > Imaging & Optics > Sensors and Detection > Remote Sensing
Immunotherapy That Converts Glioblastoma Cells Into Immune Cells to Attack Cancerous Tumors
Converts Cancer Cells to Immune Cells that Recruit Body’s Own Immune System to Target Brain Tumors This immunotherapy directly reprograms cancer cells into immune cells, specifically dendritic cells, making the reprogrammed cancer cells a therapy for the rest of the tumor. Glioblastoma (GBM) is the most common and lethal brain cancer in adults....
Published: 6/27/2021
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Inventor(s):
David Tran
,
Son Le
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
,
Technology Classifications > Human Health Care > Gene Therapy
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit Endospores
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit EndosporesResearchers at Augusta University have invented skin-friendly compositions and methods for killing, inactivating, or otherwise reducing the bacterial endospores by using an effective amount of the green tea EGCG or its derivatives. EGCG research shows clear application for a hand sanitizer...
Published: 4/21/2023
|
Inventor(s):
Stephen Hsu
,
Lee Lee
,
Tin-Chun Chu
Keywords(s):
Category(s):
Therapeutics
Mitochondrial-Targeted Peptide Modulators of Delta Protein Kinase C Interaction with the d-subunit of F1Fo ATP Synthase/ATPase as Therapeutics Against Cardiac Injury
Current State of the Art: Current clinical therapy for heart attack victims focuses on the rapid restoration of blood flow by thrombolysis, angioplasty, stenting and when appropriate surgical coronary artery bypass grafts. Problems with the Current Art: The majority of cardiac cell death associated with a heart attack actually occurs during the...
Published: 4/29/2020
|
Inventor(s):
John Johnson
,
Tiffany Tuyen Nguyen
,
Mourad Ogbi
Keywords(s):
Cardiovascular
,
Heart Attack
,
Therapeutics
Category(s):
Therapeutics
2015-288 TRP: Derivation of a Human Neuroendocrine Prostate Cancer Cell Line with Defined Oncogenic Drivers
Derivation Of A Human Neuroendocrine Prostate Cancer Cell Line With Defined Oncogenic DriversSUMMARYResearchers at UCLA have developed a malignant neuroendocrine prostate cancer cell line that was derived from benign human prostate tissue and transformed with the oncogenes MYCN and myristoylated AKT1.BACKGROUNDHuman cell lines are an important component...
Published: 7/19/2023
|
Inventor(s):
Owen Witte
,
John Lee
Keywords(s):
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Cell Lines
Surfaceome Profiling of Advanced Prostate Cancer to Identify Target Antigens for Immune-Based Therapy (UCLA Case. No. 2018-571)
Surfaceome Profiling Of Advanced Prostate Cancer To Identify Target Antigens For Immune-Based TherapySUMMARYDr. Witte and colleagues at UCLA have developed a novel approach to identify surface biomarkers and targetable antigens in prostate cancer by combining multiple omics analyses across different cell lines.BACKGROUNDProstate cancer is the most common...
Published: 9/19/2024
|
Inventor(s):
Owen Witte
,
John Lee
,
Nathanael Bangayan
Keywords(s):
Life Science Research Tools
,
Research Methods
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Research Methods
Liquid Biopsy Screening for Early Detection of Cancers in Patients
Highly Sensitive, Specific and Low Cost Method of Detecting Cancer in Bodily Fluids by Analyzing the Accessibility and Expression of Cancer Master Gene RegulatorsThis non-invasive method of liquid biopsy screening much more sensitively and specifically detects cancer in patients, including those with rare or novel mutations with cost in the order of...
Published: 6/27/2021
|
Inventor(s):
David Tran
,
Son Le
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Diagnostics
Adaptive System that Records Cellular Lineage, Cellular Clock, and Cellular Memory Simultaneously
Diary Reveals a Comprehensive History of a Cell that Aids Research, Diagnostics, and TherapeuticsThis molecular cell diary system is capable of creating a detailed understanding of a cell’s history and current state, including its cellular lineage, cellular clock, and cellular memory. The molecular diagnostics market in 2014 was globally worth...
Published: 6/27/2021
|
Inventor(s):
David Tran
,
Son Le
Keywords(s):
cellular barometer
,
cellular clock
,
cellular events tracking
,
cellular memory
,
lineage tracing
,
mutational history
Category(s):
Technology Classifications > Human Health Care > Diagnostics
,
Technology Classifications > Research Tools > Diagnostics
,
Technology Classifications > Research Tools > Others
,
Technology Classifications > Research Tools > Vectors
,
Technology Classifications > Software > Others
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