Search Results - jing+chen

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Controlled Tunnel Gap Device for Sequencing Polymers
To reduce costs and increase the availability of personalized genomics new approaches to DNA sequencing are required. Nanopore sequencing is one proposed technique. In nanopore sequencing, DNA molecules are forced through a tiny aperture by electrophoresis. As the individual bases transit the nanopore, their identity can be determined, in theory, by...
Published: 10/17/2024   |   Inventor(s): Stuart Lindsay, Shuai Chang, Jin He, Peiming Zhang, Shuo Huang
Keywords(s): Bio-Technology
Category(s): Life Science (All LS Techs)
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government’s pursuit of the “Thousand Dollar Genome” and the “X Prize” goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will...
Published: 10/17/2024   |   Inventor(s): Stuart Lindsay, Colin Nuckolls, Jinyao Tang, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Proteomic Assays/Reagents/Tools
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government's pursuit of the "Thousand Dollar Genome" and the "X Prize" goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will open a new...
Published: 10/17/2024   |   Inventor(s): Stuart Lindsay, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023   |   Inventor(s): Yu Qian, Yi Wang, Chen Chen
Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation
Category(s): Engineering and Physical Sciences
Combination Therapy to Overcome Resistance to Platinum-Based Chemotherapy
Application MAST1 inhibitors to overcome resistance to platinum-based chemotherapy, exacerbated by dexamethasone co-administration. Key Benefits Co-administration of MAST1 inhibitor and MAST1-stabilizing protein inhibitor abrogates tumor resistance to cisplatin MAST1 inhibitor, lestaurtinib, has previously reached phase III clinical trials and...
Published: 7/30/2024   |   Inventor(s): Sumin Kang, Jing Chen
Keywords(s): Oncology
Category(s): TechPub Algolia > Therapeutics
2015-671 Underground Shafts for Hydrogen Storage
SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...
Published: 7/19/2023   |   Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove
Keywords(s): Energy & Water
Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage
Cancer Cell Metabolism Inhibitors for Targeted Therapies
Application Glutamate dehydrogenase (GDH1) inhibitors targeting cancer cell metabolic pathways. Key Benefits Targets tricarboxylic acid (TCA) cycle/mitochondrial metabolism utilized by several cancer cell types for cell growth and survival. Reduces cell proliferation and viability in several tumor derived cell lines as well as in xenograft tumor...
Published: 7/30/2024   |   Inventor(s): Sumin Kang, Jing Chen, Lingtao Jin
Keywords(s): Oncology, Small Molecule
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
DHAA and Derivatives for Treatment of BRAF-V600E-Positive Cancer
Application Hypolipidemic dehydroacetic acid (DHAA) treatment to prevent growth of BRAF V600E positive tumors. Key Benefits Treatment with slows BRAF V600E-positive tumor growth. Repurposed compound may speed FDA approval. May be used in combination with other therapies. Market Summary Up to 50% of melanoma cases harbor the BRAF V600E mutation,...
Published: 9/26/2024   |   Inventor(s): Jing Chen, Jack Arbiser, Brian Pollack, Siyuan Xia
Keywords(s): Enzyme/Protein, Oncology, Repurposed Drug
Category(s): TechPub Algolia > Therapeutics
Dynamic Environmental Photosynthetic Imaging Apparatus and Methods
Executive SummaryDue to the complexity of measuring photosynthetic rates of plants, research in improving crop yield has placed little attention on photosynthesis thus far and instead relied on traditional parameters such as crop architecture and growth cycles. Thus, there is a significant unexploited potential to increase the food and biomass output...
Published: 2/17/2023   |   Inventor(s): David Kramer, Jin Chen, Elisabeth Ostendorf, Lei Xu, Jeffrey Cruz, Jeremy Brodersen
Keywords(s):  
Category(s): Agriculture, Biotechnology