Search Results - daniel+powell

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CD137 enrichment of tumor-specific tumor-infiltrating lymphocytes (TILs)
A platform to isolate and expand CD137-positive (CD137pos) tumor-infiltrating lymphocytes (TILs) to use in adoptive immunotherapy and translational studies. Problem: Adoptive immunotherapy using either naturally occurring or genetically modified tumor-infiltrating lymphocytes (TILs) is being developed to treat solid tumors clinically. However, methods...
Published: 11/11/2024   |   Inventor(s): Daniel Powell
Keywords(s): CAR T-cell Enhancing Technology, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
CAR T cell therapy for the treatment of ovarian cancer and other gynecologic malignancies
Anti-Mullerian inhibiting substance type II receptor (MISRII) specific CAR T cell therapy for the targeted, safe treatment of ovarian cancer. Technology Overview: Ovarian cancer is the 5th leading cause of cancer-related deaths in women and is the most lethal of all gynecologic malignancies with an overall 5-year survival rate of 46%. The Müllerian...
Published: 11/11/2024   |   Inventor(s): Daniel Powell, Alba Rodriguez-Garcia
Keywords(s):  
Category(s): Technology Classifications > Therapeutics
Fully human anti-mesothelin CAR with low immunogenicity for in vivo persistence of anti-tumor engineered T cells
The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing...
Published: 11/11/2024   |   Inventor(s): Daniel Powell
Keywords(s): Antibody, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s): Technology Classifications > Therapeutics
Single viral vector for expression of both CAR/TCR and immune modulators for cancer immunotherapy
A single lentiviral vector system as an expression platform for constitutive immune receptor expression and inducible antigen-dependent immunomodulatory molecule expression in primary immune cells for enhanced immunotherapy efficacy Problem: Adoptive cancer immunotherapy, like chimeric antigen receptor T cell (CAR T) therapy, has had extraordinary...
Published: 11/11/2024   |   Inventor(s): Daniel Powell, Anze Smole, Avery Posey
Keywords(s): CAR T-cell Enhancing Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
A Natural Mouse Model that Enables the Discovery and Characterization of Bacterial and Host Factors that Mediate Neisseria Colonization and Persistence, and Targets for Vaccines and Antimicrobials
This technology is a natural small animal model that circumvents the barriers of host restriction, often seen when studying Neisseria species. This model can be used to study host determinants controlling colonization resistance and factors involved in Neisseria-host interactions and screening therapeutics and vaccines against Neisseria. Background: Neisseria...
Published: 4/3/2023   |   Inventor(s): Magdalene So, Jeffrey Frelinger, Man Cheong Ma, Daniel Powell, Katherine Rhodes, Nathan Weyand
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Infectious Diseases