Search Results - car+t-cell+enhancing+technology

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Compositions and Methods for Enhancing the Anti-Tumor Activity of CAR T Cells by Co-Expression of CH25H
Co-expression of modified chimeric antigen receptor (CAR) T cells and cholesterol 25-hydroxylase (CH25H) in a single construct for treatment of solid tumor and hematological cancers. Problem: CAR T cell therapy is a treatment in which T cells collected from a patient are engineered to produce CARs that recognize and attack cancer cells. While it...
Published: 7/11/2024   |   Inventor(s): Serge Fuchs, Noreen McBrearty, Zhen Lu
Keywords(s): Bioengineering, CAR T-cell Enhancing Technology, Cell Therapy, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics
CD137 enrichment of tumor-specific tumor-infiltrating lymphocytes (TILs)
A platform to isolate and expand CD137-positive (CD137pos) tumor-infiltrating lymphocytes (TILs) to use in adoptive immunotherapy and translational studies. Problem: Adoptive immunotherapy using either naturally occurring or genetically modified tumor-infiltrating lymphocytes (TILs) is being developed to treat solid tumors clinically. However, methods...
Published: 11/11/2024   |   Inventor(s): Daniel Powell
Keywords(s): CAR T-cell Enhancing Technology, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Single viral vector for expression of both CAR/TCR and immune modulators for cancer immunotherapy
A single lentiviral vector system as an expression platform for constitutive immune receptor expression and inducible antigen-dependent immunomodulatory molecule expression in primary immune cells for enhanced immunotherapy efficacy Problem: Adoptive cancer immunotherapy, like chimeric antigen receptor T cell (CAR T) therapy, has had extraordinary...
Published: 11/11/2024   |   Inventor(s): Daniel Powell, Anze Smole, Avery Posey
Keywords(s): CAR T-cell Enhancing Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics