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Compositions and Methods for Enhancing the Anti-Tumor Activity of CAR T Cells by Co-Expression of CH25H
Co-expression of modified chimeric antigen receptor (CAR) T cells and cholesterol 25-hydroxylase (CH25H) in a single construct for treatment of solid tumor and hematological cancers. Problem: CAR T cell therapy is a treatment in which T cells collected from a patient are engineered to produce CARs that recognize and attack cancer cells. While it...
Published: 7/11/2024   |   Inventor(s): Serge Fuchs, Noreen McBrearty, Zhen Lu
Keywords(s): Bioengineering, CAR T-cell Enhancing Technology, Cell Therapy, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics