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Pharmacological strategy to treat hydrocephalus
This technology offers a non-surgical treatment for hydrocephalus by using drugs to enhance the removal of harmful macromolecules from the brain’s ventricles, targeting specific cellular transport mechanisms to reduce fluid buildup and disease progression. Background: Hydrocephalus is a neurological disorder characterized by the abnormal accumulation...
Published: 1/26/2026   |   Inventor(s): Satish Krishnamurthy, David Lehmann
Keywords(s): hydrocephalus, pharmacology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare
“Smart” Electronic Rotating Hemostatic Valve and Tuohy-Borst Adapter with Integrated Activation and Force Sensors with Interface with Heads-Up Electronic Displays and Cloud-Based Data Analysis To Optimize Technical Safety, Display Live Quantified Operator Variables and Inform Individualized Procedural Technique
This technology measures, records, and displays force measurements exerted on catheters, providing valuable data to improve patient outcomes. Background: Rotating hemostatic valves (RHV) and Tuohy-Borst adapters (TBA) are used with catheter-based and other relevant procedures. Currently available RHVs and TBAs lack integrated sensors to provide feedback...
Published: 1/23/2026   |   Inventor(s): Hesham Masoud, Andrew Decker
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare
Self-delivery USP10 siRNA to promote regenerative healing-new IP
This technology employs an engineered self-delivering siRNA to selectively reduce USP10 protein levels in tissues, thereby promoting regenerative healing and suppressing pathological scarring. Preclinical studies in the eye demonstrate a favorable safety profile and robust efficacy, supporting the potential of this approach for treating fibrotic disease...
Published: 1/21/2026   |   Inventor(s): Audrey Bernstein, Sean McCauley, Alexey Wolfson, Tere Williams
Keywords(s): fibrosis, opthalmology, scarring, siRNA, skin diseases, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Campus > Upstate Medical University
Lipid nanoparticles for targeted delivery of therapeutic agents in acute lung injury
This technology uses lung-targeting lipid nanoparticles to deliver a combination of anti-inflammatory and immune-modulating drugs directly to the lungs, offering a more effective and targeted treatment for acute lung injury and acute respiratory distress syndrome. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...
Published: 1/15/2026   |   Inventor(s): Yamin Li, Yuqin Men, Robert Cooney, Qinghe Meng
Keywords(s): acute lung injury, anti-inflammatory therapeutic, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
Rapid, robust, and near point-of-care saliva-based nucleic acid detection of dengue virus infections
This technology enables rapid, non-invasive detection and differentiation of all four dengue virus serotypes using saliva samples, with advanced qPCR and RT-LAMP assays, making dengue diagnosis easier, faster, and more accessible without the need for blood draws. Background: Dengue virus (DENV) is a major global health concern, with hundreds of millions...
Published: 1/15/2026   |   Inventor(s): Frank Middleton, Stephen Thomas, Adam Waickman, Timothy Rooney
Keywords(s): diagnostics, disease diagnosis, isothermal amplification (LAMP), nucleic acid, PCR, RNA viruses, saliva, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Screens and Assays, Technology Classifications > Biomedical Science and Engineering
Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells
This technology uses specially designed sulfonium lipid nanoparticles to deliver mRNA directly to lung cells through the nose, offering a non-invasive, more effective and targeted treatment for pulmonary diseases like asthma and cystic fibrosis. Background: The field of pulmonary medicine faces significant challenges in the treatment of diseases...
Published: 1/9/2026   |   Inventor(s): Yamin Li, Yuqin Men
Keywords(s): active pharmaceutical ingredient, chemicals, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery
A Method for Controlling Suction and Specimen Collection During Endoscopic Procedures
A method to precisely control the amount of pressure applied by the fluid flow from the lithotripsy device with a stopcock. Background: In percutaneous nephrolithotomy, the urologist inserts a needle into the kidney, dilating a tract into which a sheath is inserted. Fluid irrigation and lithotripsy are then used to break up and retrieve kidney stones...
Published: 12/16/2025   |   Inventor(s): Scott Wiener
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Medical Devices
Decision Support Tool for Detection of Prostate Lesions on MRI
Prostate cancer diagnostic software that provides expert-level lesion detection, localization, automated segmentation, and automated report generation in less than 45 seconds. Background: According to the American Cancer Society, about 1 in 8 men will be diagnosed with prostate cancer during their lifetime. American Urologic Association guidelines...
Published: 9/25/2025   |   Inventor(s): Thomas Sanford, Gennady Bratslavsky
Keywords(s): magnetic resonance imaging, oncology, prostate, software, Technologies
Category(s): Technology Classifications > Healthcare IT, Campus > Upstate Medical University
Luminescent Biosensor for Detection of Specific Nucleotide Sequences, Small Molecules, and Proteins at Point-of-Care
A serotonin release assay that requires no special training or expensive equipment, and produces results within hours. Background: Platelet serotonin release assay (SRA) is a widely-used clinical assay for diagnosing heparin-induced thrombocytopenia (HIT), a life-threatening complication of heparin treatment. The current SRA procedure entails sending...
Published: 1/20/2026   |   Inventor(s): Stewart Loh, Harsimranjit Sekhon
Keywords(s): biomarker diagnostics, biosensor, detection, DNA nanoswitches, protein engineering, sensor, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines
Engineered Telodendrimer Nanocarriers for Monomeric Amphotericin B Delivery
A nanocarrier platform for Amphotericin B that improves efficacy and reduces cost, while decreasing toxicity. Background: Systemic fungal infections are an increasingly prevalent health problem. The hydrophobic polyene antibiotic Amphotericin B (AmB) is the drug of choice for these life-threatening invasive fungal infections. Unfortunately, it produces...
Published: 12/4/2025   |   Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines
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