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Methods and Compositions for Prevention and Mitigation of Radiation-Induced Cardiac Injury Using GLP-1 Receptor Agonists
This technology utilizes glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, to prevent and treat radiation-induced cardiac injury, offering a novel medical approach to protect the heart from damages caused by ionizing radiation. Background: Radiation-induced heart disease (RIHD) is a serious complication arising from exposure...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Snehalata Pawar, Suresh Veeraperumal
Keywords(s): cardiovascular, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Bioactive Telodendrimer Nanocarrier for Antibiotics Delivery and Immune Modulation
Novel telodendrimer nanoparticles have been developed to enhance the delivery and safety profile of the antibiotic Polymyxin B by improving its stability and reducing toxicity during treatment. Background: Polymyxin B (PMB) is a powerful antibiotic used to treat infections caused by Gram-negative bacteria, but its clinical application is limited...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Juntao Luo, Dandan Guo, Md Shanewaz Hossan, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
Small Peptides Targeting Lactate Dehydrogenase-A
This technology presents engineered peptide inhibitors designed to selectively block lactate dehydrogenase A (LDHA) activity, offering a novel therapeutic approach for diseases characterized by elevated LDHA, such as cancer and metabolic disorders. Background: Lactate dehydrogenase A (LDHA) is an enzyme that plays a key role in cellular metabolism...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Mark Woodford
Keywords(s): FLCN, lactate dehydrogenase, metabolic switch, tumor suppressor, Warburg effect
Category(s): Campus > Upstate Medical University
Pancreas-specific mRNA delivery enabled by sulfonium lipid nanoparticles
This technology presents a novel class of lipid nanoparticles engineered for targeted delivery of mRNA specifically to the pancreas following systemic administration. Background: Effective delivery of RNA therapeutics to specific organs remains a significant challenge in biomedical research. The pancreas, in particular, has been a difficult target...
Published: 6/12/2026   |   Updated: 6/11/2026   |   Inventor(s): Yamin Li, Yuqin Men
Keywords(s): mRNA, nanoparticle-enhanced delivery, nanoparticles, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
A lung-targeting britannin-lipid nanoparticle formulation and use thereof
This technology is a novel lung-targeting britannin-lipid nanoparticle formulation designed to effectively treat acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) by inhibiting lung inflammation. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe lung conditions characterized by intense...
Published: 6/12/2026   |   Updated: 6/11/2026   |   Inventor(s): Yamin Li, Qinghe Meng, Daping Fan
Keywords(s): acute lung injury, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
Development of novel liver-targeting glucocorticoid prodrugs
This technology presents novel liver-targeting glucocorticoid prodrugs designed to improve the treatment of inflammatory liver diseases and sepsis with enhanced efficacy and reduced systemic side effects. Background: Inflammatory liver diseases and sepsis represent significant clinical challenges due to their complex immune responses and the difficulty...
Published: 6/12/2026   |   Updated: 6/11/2026   |   Inventor(s): Hong Lu, Juntao Luo, Dandan Guo
Keywords(s): glucocorticoid, inflammatory liver disease, liver-selective, nanoparticle, prodrug, sepsis, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
Enhancement of adaptive immune responses by post-inoculation administration of fenretinide (N-(4-hydroxyphenyl)retinamide)
This technology uses fenretinide, a synthetic vitamin A derivative, to boost the body’s adaptive immune response after vaccination or infection, making vaccines more effective, especially for poorly immunogenic agents or immunocompromised individuals, without increasing infection severity. Background: The field of vaccine development and immunotherapy...
Published: 6/1/2026   |   Updated: 5/29/2026   |   Inventor(s): Adam Waickman, Stephen Thomas, David Foster, Herbert Slade
Keywords(s): Technologies, vaccine stability, vaccines
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Tibial Tubercle Osteotomy Fixation Device
Fixation device to secure bone fragment of tibial tuberosity to native bone after osteotomy surgical procedure. Background: Standard osteotomy techniques to join the tibial tubercle fragment to native bone include screw fixation alone or fixation with wire or suture, which are not reliable methods to holding the bone in place to avoid displacement...
Published: 5/13/2026   |   Updated: 5/13/2026   |   Inventor(s): Timothy Damron
Keywords(s): biomedical, biomedical engineering, hardware, healthcare, instrumentation, medical devices, medical equipment, orthopedics, osteoarthritis, surgery, suturing technique, Technologies
Category(s): Technology Classifications > Medical Devices, Campus > Upstate Medical University
Electromotive anti fibrotic substance administration for fibrotic diseases
This technology uses a gentle electrical current to deliver antifibrotic drugs like collagenase directly into fibrotic tissues, such as the bladder wall, enabling noninvasive, targeted treatment of fibrosis and improving tissue function without surgery. Background: Fibrosis of the bladder wall, particularly in the context of neurogenic bladder, represents...
Published: 4/28/2026   |   Updated: 4/28/2026   |   Inventor(s): Jeffrey Villanueva
Keywords(s): fibrosis, fibrous materials, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
Developing a new mechanism-based method to treat behavioral variant frontotemporal dementia
This technology offers a novel, mechanism-based therapeutic method using oxytocin and specific compounds to treat social-affective deficits in behavioral variant frontotemporal dementia (bvFTD). Background: Behavioral variant frontotemporal dementia (bvFTD) is a prevalent form of dementia characterized by severe social and emotional impairments,...
Published: 3/30/2026   |   Updated: 3/30/2026   |   Inventor(s): Wei-Dong Yao
Keywords(s): dementia, electrophysiology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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