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Search Results - zhongliang+ouyang
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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025
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Inventor(s):
Li Li
,
Shichao Wu
,
Jiawei Zhao
Keywords(s):
Category(s):
Technology Category > Research tools
,
Technology Category > Animal models
,
Technology Category > Biology
,
Technology Category > Diagnostic
Multi-parametric Acoustic, Optical and Mechanical Imaging of Cervical Tissue Insufficiencies to Predict Preterm Birth
An enhanced image-guidance system that integrates ultrasound and photoacoustic into existing ablation systems to provide an enhanced image-guidance system for identification of cervical tissue changes during pregnancy and postpartum. Technology Summary Preterm delivery is a main cause of perinatal morbidity and mortality worldwide, which is associated...
Published: 10/1/2025
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Inventor(s):
Mohammad Mehrmohammadi
,
Sonia Hassan
,
Edgar Hernandez-Andrade
,
Yan Yan
,
Maryam Basij
Keywords(s):
Driving Lifelong Health
Category(s):
Technology Category > Women's Health
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Technology Category > Medical Devices
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Technology Category > Life Science
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Technology Category > Imaging
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Technology Category > Acoustics
DHODH Inhibitors
This technology includes novel compounds that selectively inhibit fungal dihydroorotate dehydrogenase (DHODH), an essential enzyme in pyrimidine biosynthesis. These inhibitors are active against a range of fungal pathogens, including Cryptococcus neoformans and Candida auris, while sparing the human version of the enzyme. This selectivity reduces the...
Published: 8/18/2025
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Inventor(s):
Hongmin Li
,
Anil Tharappel
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Infectious Diseases
,
Technology Classifications > Life Sciences > Small Molecules
Rapid UV Light Annealing of Perovskite Active Layers
The Problem: Perovskite solar cells present several advantages over traditional solar cells. However, in order to maximize their commercial potential, perovskite must be rapidly annealed for mass production. Thermal annealing involving hot plates or ovens is lengthy and not energy efficient. The application of this method is very time-consuming and...
Published: 10/2/2024
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Inventor(s):
Dawen Li
,
Zhongliang Ouyang
Keywords(s):
Category(s):
Technology Classifications > Manufacturing
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Technology Classifications > Energy
Small Molecules with Antifungal Activity for Cryptococcosis
Researchers at the University of Arizona have found 140 novel antifungal compounds with the potential to treat cryptococcosis. These compounds have anti-Cryptococcus neoformans activity with IC50 less than 10 uM. Background: Fungal infections, although not very contagious, have affected 300 million people worldwide. Cryptococcosis is caused by opportunistic...
Published: 1/10/2024
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Inventor(s):
Hongmin Li
,
Anil Tharappel
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
An OCT method to improve scleral lens fitting
Summary The current technology allows for accurate and objective 3-dimensional (3D) mapping of the external limbus, which could ultimately improve the process of scleral lens fitting. Technology Overview Rigid scleral lenses are difficult to fit to patients because they must rest on the eye but vault over the cornea and the limbus, which is the transition...
Published: 9/4/2025
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Inventor(s):
David Huang
,
Yan Li
,
Clara Llorens Quintana
Keywords(s):
Imaging
,
Imaging - Other
,
Software
,
Software - Diagnostic/Detection
Category(s):
Imaging
,
Software
Broad Spectrum Inhibitors against Viral Methyltransferases
This innovation is a universal high throughput screening (HTS) assay to identify inhibitors targeting a binding site of viral methyltransferases (MTases) with a methyl donor. The inventors developed a fluorescence polarization (FP)-based HTS assay to target reference MTases, an essential enzyme to methylate the 5’-cap of viral RNA genome on SARS-CoV-2...
Published: 11/16/2023
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Inventor(s):
Hongmin Li
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
High-Throughput Direct-Measurement of Telomere Length
Telomeres are linear chromosome end-capping repetitive DNA sequences. They serve to protect the ends of chromosomes from undesirable fusion events, thus integrity and length are crucial for stability. Natural attrition as well as mutations can affect telomere integrity and length resulting in chromosome instability, senescence, cell death and human...
Published: 2/26/2026
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Inventor(s):
Julian Chen
,
Yang Li
,
Dhenugen Logeswaran
Keywords(s):
Category(s):
Bioanalytical Assays, Chemistries & Devices
,
Diagnostic Assays/Devices
,
Genomic Assays/Reagents/Tools
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Life Science (All LS Techs)
,
Medical Diagnostics/Sensors
Learning Sparse Features for Self-Supervised Learning with Contrastive Dual Gating
The success of conventional supervised learning relies on large-scale labeled datasets to achieve high accuracy. However, annotating millions of data samples is labor-intensive and time-consuming. This promotes self-supervised learning as an attractive solution with artificial labels being used instead of human-annotated ones for training. Contrastive...
Published: 2/13/2025
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Inventor(s):
Jae-Sun Seo
,
Jian Meng
,
Li Yang
,
Deliang Fan
Keywords(s):
Algorithm Development
,
Machine Learning
,
Performance Optimization
,
PS-Computing and Information Technology
Category(s):
Computing & Information Technology
,
Physical Science
Temperature-Resilient RRAM-Based In-Memory Computing for DNN Inference
Deep neural networks (DNNs) have shown extraordinary performance in recent years for various applications, including image classification, object detection, speech recognition, etc. Accuracy-driven DNN architectures tend to increase model sizes and computations in a very fast pace, demanding a massive amount of hardware resources. Frequent communication...
Published: 2/26/2026
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Inventor(s):
Jae-Sun Seo
,
Jian Meng
,
Li Yang
,
Deliang Fan
Keywords(s):
Algorithm Development
,
Machine Learning
,
Memory
,
Neural Computing
,
PS-Computing and Information Technology
Category(s):
Computing & Information Technology
,
Physical Science
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