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Search Results - zhong-lin+lu
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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025
|
Inventor(s):
Li Li
,
Shichao Wu
,
Jiawei Zhao
Keywords(s):
Category(s):
Technology Category > Research tools
,
Technology Category > Animal models
,
Technology Category > Biology
,
Technology Category > Diagnostic
Ultrafast Thin-Film Vapor Deposition Technique
Invention Description The demand for advanced thin-film deposition techniques has grown substantially in recent years, driven by the development of next-generation electronic, optoelectronic, and energy devices. Traditional deposition methods, such as chemical vapor deposition, molecular beam epitaxy, and physical vapor deposition, have well-established...
Published: 11/18/2025
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Inventor(s):
Feng Yan
,
Lin Li
Keywords(s):
Category(s):
Semiconductors, Materials & Processes
,
Microelectronics
,
Physical Science
,
Semiconductor Devices
,
Manufacturing/Construction/Mechanical
DHODH Inhibitors
This technology includes novel compounds that selectively inhibit fungal dihydroorotate dehydrogenase (DHODH), an essential enzyme in pyrimidine biosynthesis. These inhibitors are active against a range of fungal pathogens, including Cryptococcus neoformans and Candida auris, while sparing the human version of the enzyme. This selectivity reduces the...
Published: 8/18/2025
|
Inventor(s):
Hongmin Li
,
Anil Tharappel
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Infectious Diseases
,
Technology Classifications > Life Sciences > Small Molecules
Small Molecules with Antifungal Activity for Cryptococcosis
Researchers at the University of Arizona have found 140 novel antifungal compounds with the potential to treat cryptococcosis. These compounds have anti-Cryptococcus neoformans activity with IC50 less than 10 uM. Background: Fungal infections, although not very contagious, have affected 300 million people worldwide. Cryptococcosis is caused by opportunistic...
Published: 1/10/2024
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Inventor(s):
Hongmin Li
,
Anil Tharappel
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Method for Measuring Human Vision Cortical Magnification Factor
In human vision, varying amounts of neural resources are devoted to visual fields. Retinotopic mapping uses fMRI to give a projection of the visual field and its cortical representation in a subject. Cortical magnification factor (CMF) is a common measure of the ratio of the cortical areas devoted to each region of the visual field, to show visual acuity...
Published: 2/13/2025
|
Inventor(s):
Yujian Xiong
,
Zhong-Lin Lu
,
Yalin Wang
Keywords(s):
Category(s):
Applied Technologies
,
Computing & Information Technology
,
Diagnostic Assays/Devices
,
Imaging
,
Life Science (All LS Techs)
,
Medical Imaging
Broad Spectrum Inhibitors against Viral Methyltransferases
This innovation is a universal high throughput screening (HTS) assay to identify inhibitors targeting a binding site of viral methyltransferases (MTases) with a methyl donor. The inventors developed a fluorescence polarization (FP)-based HTS assay to target reference MTases, an essential enzyme to methylate the 5’-cap of viral RNA genome on SARS-CoV-2...
Published: 11/16/2023
|
Inventor(s):
Hongmin Li
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/1/2024
|
Inventor(s):
Hongmin Li
,
subodh samrat
,
Zhong Li
,
Jia Zhou
,
Jimin Xu
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 2/13/2024
|
Inventor(s):
Hongmin Li
,
Zhong Li
,
Qing-yu Zhang
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Life Sciences
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
A Novel High-Throughput Assay for Identifying Zike Virus NS2B-NS3 Protease Inhibitors
This invention includes a novel high-throughput assay to identify orthosteric inhibitors blocking the Zika virus NS2B-NS3 protease. Pathogenic flaviviruses, including Zika, require the NS2B-NS3 protease for viral replication. There is currently an unmet need for specific antiviral therapeutics against the Zika virus. Preliminary screening using the...
Published: 8/13/2025
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Inventor(s):
Menghang Xia
,
Ruili Huang
,
Laura Kramer
,
Zhong Li
,
Hongmin Li
Keywords(s):
Activity
,
Antiflaviviral
,
Compositions
,
PHARMACEUTICAL
,
VLXXXX
,
WIXXXX
,
WKXXXX
,
XHXXXX
Category(s):
TherapeuticArea > Infectious Disease
,
Application > Therapeutics
,
ResearchProducts > Research Equipment
,
Application > Research Materials
Self-neutralizing air-breathing thruster and method of neutralization
An ion-engine is the cutting edge for atmospheric air-breathing engines. The technology depends on ionizing and neutralizing atmospheric air particles which create thrust. This unique possibility makes it an ideal choice for very-low-orbit satellites. Very- low-orbit satellite capabilities have benefits such as higher resolution for images, weight...
Published: 12/8/2025
|
Inventor(s):
Michael Keidar
,
Anmol Taploo
,
Li Lin
Keywords(s):
Category(s):
Technology Classifications > Computers Electronics & Software
,
Technology Classifications > Computers Electronics & Software > Aviation
,
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
,
Technology Classifications > Industrial or Consumer Tech > Industrial Manufacturing
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