Inteum Company
Links
seedsprint
Visible Legacy
RSS
News & Resources
Inteum Company News
Inteum Library
Subscribe
Search Results - zhong-lin+lu
17
Results
Sort By:
Published Date
Updated Date
Title
ID
Descending
Ascending
Small Molecules with Antifungal Activity for Cryptococcosis
Researchers at the University of Arizona have found 140 novel antifungal compounds with the potential to treat cryptococcosis. These compounds have anti-Cryptococcus neoformans activity with IC50 less than 10 uM. Background: Fungal infections, although not very contagious, have affected 300 million people worldwide. Cryptococcosis is caused by opportunistic...
Published: 1/10/2024
|
Inventor(s):
Hongmin Li
,
Anil Tharappel
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Method for Measuring Human Vision Cortical Magnification Factor
In human vision, varying amounts of neural resources are devoted to visual fields. Retinotopic mapping uses fMRI to give a projection of the visual field and its cortical representation in a subject. Cortical magnification factor (CMF) is a common measure of the ratio of the cortical areas devoted to each region of the visual field, to show visual acuity...
Published: 1/7/2025
|
Inventor(s):
Yujian Xiong
,
Zhong-Lin Lu
,
Yalin Wang
Keywords(s):
Category(s):
Applied Technologies
,
Computing & Information Technology
,
Diagnostic Assays/Devices
,
Imaging
,
Life Science (All LS Techs)
,
Medical Imaging
Broad Spectrum Inhibitors against Viral Methyltransferases
This innovation is a universal high throughput screening (HTS) assay to identify inhibitors targeting a binding site of viral methyltransferases (MTases) with a methyl donor. The inventors developed a fluorescence polarization (FP)-based HTS assay to target reference MTases, an essential enzyme to methylate the 5’-cap of viral RNA genome on SARS-CoV-2...
Published: 11/16/2023
|
Inventor(s):
Hongmin Li
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023
|
Inventor(s):
Jianfeng Cai
,
Shibo JIANG
,
Lu LU
,
Songyi XUE
,
Xinling WANG
,
Lei WANG
,
Wei XU
,
Shuai XIA
Keywords(s):
Drug Discovery
,
Immunology
Category(s):
Technology Classifications > Medical > Biotechnology
Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/1/2024
|
Inventor(s):
Hongmin Li
,
subodh samrat
,
Zhong Li
,
Jia Zhou
,
Jimin Xu
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 2/13/2024
|
Inventor(s):
Hongmin Li
,
Zhong Li
,
Qing-yu Zhang
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Life Sciences
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
A Novel High-Throughput Assay for Identifying Zike Virus NS2B-NS3 Protease Inhibitors
This invention includes a novel high-throughput assay to identify orthosteric inhibitors blocking the Zika virus NS2B-NS3 protease. Pathogenic flaviviruses, including Zika, require the NS2B-NS3 protease for viral replication. There is currently an unmet need for specific antiviral therapeutics against the Zika virus. Preliminary screening using the...
Published: 10/28/2024
|
Inventor(s):
Menghang Xia
,
Ruili Huang
,
Laura Kramer
,
Zhong Li
,
Hongmin Li
Keywords(s):
Activity
,
Antiflaviviral
,
Compositions
,
PHARMACEUTICAL
,
VLXXXX
,
WIXXXX
,
WKXXXX
,
XHXXXX
Category(s):
TherapeuticArea > Infectious Disease
,
Application > Therapeutics
,
ResearchProducts > Research Equipment
,
Application > Research Materials
Self-neutralizing air-breathing thruster and method of neutralization
An ion-engine is the cutting edge for atmospheric air-breathing engines. The technology depends on ionizing and neutralizing atmospheric air particles which create thrust. This unique possibility makes it an ideal choice for very-low-orbit satellites. Very- low-orbit satellite capabilities have benefits such as higher resolution for images, weight...
Published: 7/30/2024
|
Inventor(s):
Michael Keidar
,
Anmol Taploo
,
Li Lin
Keywords(s):
Category(s):
Technology Classifications > Computers Electronics & Software
,
Technology Classifications > Computers Electronics & Software > Aviation
,
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
,
Technology Classifications > Industrial or Consumer Tech > Industrial Manufacturing
Non-Invasive Plasma Discharge Tube Device for Treating Brain Tumors
Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very effective in treating recurring tumors, and have significant clinical toxicity. A novel Plasma Discharge Tube (PDT) device has the potential to be more effective and less...
Published: 7/30/2024
|
Inventor(s):
Michael Keidar
,
Li Lin
,
Vikas Soni
,
Xiaoliang Yao
,
Dayun Yan
,
Jonathan Sherman
Keywords(s):
Category(s):
Technology Classifications > Medical Devices
,
Technology Classifications > Medical Devices > Surgical
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024
|
Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
1
2