Search Results - jia+zhou

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Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/1/2024   |   Inventor(s): Hongmin Li, subodh samrat, Zhong Li, Jia Zhou, Jimin Xu
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
Bi-Functional RGD Peptide and a Co-Signaling Mechanism to Promote Therapeutic Angiogenesis
Bi-Functional RGD Peptide to Promote Therapeutic Angiogenesis, Treat Ischemic Diseases Technology: While previous studies have focused on the identification of biological ligands to improve the functions of endothelial cells, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide functionalized...
Published: 3/23/2023   |   Inventor(s): Chung-Jen (James) Chou, Ying Mei, Jia Jia
Keywords(s):  
Category(s): BioPharma