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Search Results - qing-yu+zhang
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3D-printed biosensors for high-sensitivity molecular detection
This invention describes the creation of highly sensitive biosensors through 3D printing using stereolithography (SLA). These biosensors, made from a biopolymer blend with specific monomers and a photoinitiator, are functionalized with recognition molecules to detect small and large analytes, including disease markers, in commercial well plates. Background Additive...
Published: 7/26/2024
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Inventor(s):
Mohammed Maniruzzaman
,
Yu Zhang
Keywords(s):
Category(s):
Life sciences > Research tools > Tool/assay/screening platform
,
Life sciences > Diagnostic
“Bio-Flex”: advanced formulation for sustainable stereolithography (SLA)
Background/problem Stereolithography (SLA) 3D printing has transformed the biomedical field with creation of highly accurate, patient-specific medical devices such as tissue scaffolds, implants, and surgical tools. This technology leverages computer-aided design and medical imaging data to produce structures with precise geometries at submicron scales....
Published: 7/26/2024
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Inventor(s):
Mohammed Maniruzzaman
,
Yu Zhang
,
Anqi Lu
Keywords(s):
Category(s):
Life sciences > Medical technology > Medical devices
,
Life sciences > Therapeutics > Drug delivery
Thermal Control During Additive Manufacturing
THE CHALLENGE Additive manufacturing (AM) has emerged as a powerful tool within engineering. Many AM and coating processes rely on thermal input to soften or melt the materials involved in processing. However, this melting or softening typically results in a higher thermal gradient between deposited material and the workpiece, commonly resulting in...
Published: 12/20/2023
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Inventor(s):
Robert Griffiths
,
David Garcia
,
Hang Yu
Keywords(s):
Category(s):
EXPERIMENT--DO NOT USE
,
Technology Classifications > Additive Manufacturing
FIBP Knockout Potentiates Therapeutic Effects of T-cell Based Therapies in Solid Tumors
Abstract: Despite recent breakthroughs in cancer immunotherapy, T-cell based therapies achieve limited efficacy in solid tumors. Immunosuppression, antigen escape and physical barriers to entry into solid tumors are issues faced. Identifying regulators in T-cell dysfunction remains challenging due to limitations of current screening platforms. Using...
Published: 4/8/2024
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Inventor(s):
Peng Jiang
,
Yu Zhang
Keywords(s):
adoptive cell therapy
,
Cancer Immunotherapy
,
cholesterol metabolism
,
Computational Model
,
FGF1 Intracellular Binding Protein
,
FIBP
,
Jiang
,
solid tumors
,
T-Cell based Therapy
,
T-Cell Resilience
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Therapeutics
Automated Flight Planning System for Urban Air Mobility
Advantages: AFPS uses advanced algorithms for airspace management and conflict resolution, ensuring safety in high-density Urban air mobility (UAM) environments. AFPS enhances UAM efficiency by optimizing airspace use and generating conflict-free flight paths. AFPS allows Providers of Service for UAM (PSU) to provide seamless airspace and traffic...
Published: 9/3/2024
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Inventor(s):
Yu Zhang
Keywords(s):
Industrial Applications
,
Transportation
Category(s):
Technology Classifications > Engineering > Drones
,
Technology Classifications > Engineering > Mechanical Engineering
,
Technology Classifications > Engineering > Sensors
,
Technology Classifications > Energy & Environment
Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 2/13/2024
|
Inventor(s):
Hongmin Li
,
Zhong Li
,
Qing-yu Zhang
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Life Sciences
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
COMBINATION THERAPIES FOR COVID-19 (SARS-COV-2)
The coronavirus disease 2019 (COVID-19) is caused by a novel RNA enveloped coronavirus, SARS-CoV-2 when the virus enters human airway cells via an ACE2-mediated entry process. This entry pathway is facilitated by the cell surface heparan sulfate proteoglycan (HSPG), which enhances viral attachment to the cell surface. Researchers at NIDDK and NCATS...
Published: 7/25/2024
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Inventor(s):
Qi Zhang
,
Wei Zheng
,
Catherine Chen
,
Yihong Ye
Keywords(s):
COVID-19
,
DB4BXX
,
ENTRY
,
HEPARAN
,
option
,
Sulfate-dependent
,
Targeting
,
therapeutic
,
viral
Category(s):
Collaboration Sought > Collaboration
,
TherapeuticArea > Infectious Disease
,
Application > Therapeutics
A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells
Heparan sulfate proteoglycan (HSPG) is a group of lipid-anchored proteoglycans, engaged in a variety of key biological functions on cell surface. HSPG-mediated endocytosis of neurotoxic protein aggregates has been linked to aging related neurodegenerative diseases. Labeling HSPG is a promising technique to trace cell profile in cell research, monitor...
Published: 7/25/2024
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Inventor(s):
Qi Zhang
,
Yihong Ye
Keywords(s):
Cells
,
HEPARAN
,
Label
,
MAMMALIAN
,
MEMBRANE
,
Method
,
PLASMA
,
PROTEOGLYCAN
,
R1XXXX
,
SULFATE
,
XCXXXX
Category(s):
Collaboration Sought > Collaboration
,
Application > Diagnostics
,
Application > Research Materials
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023
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Inventor(s):
Leilei Peng
,
Yu Li
,
Han Zhang
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Medical Imaging
,
Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Method to Measure Transportation System Performance and Infrastructure Restoration
Competitive Advantages Efficient allocation of time and resources Fast decision making Optimization of multiple factors in capacity-flow transportation Summary USF inventors have created a comprehensive method to assess damages and resilience and efficiently plan repairs and reconstruction of transportation infrastructure. This novel methodology...
Published: 7/12/2023
|
Inventor(s):
Tingting Zhao
,
Yu Zhang
Keywords(s):
Category(s):
Technology Classifications > Software
,
Technology Classifications > Computer Science > C/S Transportation
,
Technology Classifications > Computer Science
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