Search Results - xin+jie+chen

8 Results

Sort By:

Fully Human Antibody Targeting Tumor Necrosis Factor Receptor Type 2 (TNFR2) for Cancer Immunotherapy

Abstract: Tumor necrosis factor receptor type 2 (TNFR2)-expressing regulatory T cells (Tregs), present in the tumor microenvironment, play an important role in tumor immune evasion. TNFR2 plays a crucial role in stimulating the activation and proliferation of Tregs, a major checkpoint of antitumor immune responses. In addition to its expression on Tregs,...

Published: 5/22/2024 | Inventor(s): Joost Oppenheim, Dimiter Dimitrov, De Yang, Xin Chen, Zhongyu Zhu

Keywords(s): ADCC, ANTIBODY, Antibody-dependent Cellular Cytotoxicity, CANCER, Immunotherapy, Oppenheim, TNFR2, Tregs, Tumor Necrosis Factor Receptor Type 2

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Novel Mouse Model for Developing Therapeutic Drugs Against Muscle Atrophy

Mouse model stably overexpressing Ant-1 for muscle atrophy therapy development. Background: Muscle disorders are commonly manifested in mitochondria-induced diseases, which are clinically referred to as mitochondrial myopathies. In classic mitochondrial myopathies, caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial...

Published: 7/11/2023 | Inventor(s): Xin Jie Chen, Xiaowen Wang

Keywords(s):

Category(s): Campus > Upstate Medical University, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering

Novel Multi-Omics Aging Clock

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools

Autonomous Drone for railroad track inspection

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...

Published: 3/15/2023 | Inventor(s): Yu Qian, Yi Wang, Chen Chen

Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation

Category(s): Engineering and Physical Sciences

CC-Hunter: Microarchitecture-Level Framework and Method for Covert Timing Channel Detection

Researchers at The George Washington University have created a microarchitecture-level framework, which implements novel methods and algorithms developed for the detection of hacking covert timing channels that are used by Trojan/spy processes in order to leak confidential information from computing environments relying on shared hardware. Information...

Published: 7/30/2024 | Inventor(s): Guru Venkataramani, Jie Chen

Keywords(s):

Category(s): Technology Classifications > Computers Electronics & Software > Cybersecurity, Technology Classifications > Computers Electronics & Software > Computing Architecture

Engineered globular endolysin, a highly potent antibacterial enzyme for multidrug resistant Gram-negative bacteria

[Licensing negotiation in progress] [Invitation for Expression of Interest- Deadline 2 July 2021] We are inviting expressions of interest (EoI) for commercializing “Engineered Globular Endolysin, a Highly Potent Antibacterial Enzyme for Multidrug Resistant Gram-Negative Bacteria” technology. The innovation is developed by Professor XIA...

Published: 10/17/2023 | Inventor(s): Jiang XIA, Shui Yee LEUNG, Xi CHEN, Miao LIU

Keywords(s):

Category(s): Biotechnology, Therapeutics

2015-671 Underground Shafts for Hydrogen Storage

SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...

Published: 7/19/2023 | Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove

Keywords(s): Energy & Water

Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage

Enzymatically Released Aryl Diazonium Ions

This invention is the discovery of triazebutadienes that rapidly release aryl diazonium ions at neutral pH with a half-life of approximately one minute. Background: In 2015, the global protein therapeutics market grew to nearly $174.7 billion due to trends in targeted therapies that resulted in fewer side effects. Monoclonal antibodies and biologics...

Published: 6/20/2024 | Inventor(s): John Jewett, Lindsay Guzman, Bereketab Mehari, Jie He

Keywords(s):

Category(s): Technology Classifications > Life Sciences