Search Results - dongmei+chen

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Exosome Gene Therapy for Treating Inner Ear Disease
Extracellular Vesicles Directly Target Inner Ear Cells to Correct Malfunctioning Genes In Vivo This in vivo gene therapy strategy combines selective gene editors with the cell targeting capability using extracellular vesicles for safe and targeted delivery., Hearing loss affects at least 1 in 500 newborns, and over 50% are hereditary in nature. One...
Published: 9/3/2024   |   Inventor(s): Mei He, Xiaoshu Pan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Drug Delivery
Droplet-Based Electroporation for High-Throughput Biomolecular Cargo Loading of Extracellular Vesicles and Exosomes
Optimizes Cargo Loading a Sub-Cellular Scale, Enabling the Scaling of Drug Manufacturing This electroporation platform enables the efficient, large-scale loading of biomolecular cargo into extracellular vesicles (EVs) and exosomes. Extracellular vesicles (EVs) are biocompatible, have fast cellular uptake, and can penetrate biological barriers, making...
Published: 4/1/2024   |   Inventor(s): Mei He
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Drug Delivery
Genomics-based Diagnostic Assay for Cancer
Abstract: Molecular profiling with high throughput assays has gained utility in the management of select cancer patients and several gene expression-based assays are now marketed for improved prognostic accuracy for patients with cancer. This technology describes a genomics based diagnostic assay for the diagnosis and prognosis of cancer patients. ...
Published: 4/8/2024   |   Inventor(s): Steven Libutti, Mei He
Keywords(s): assay, CANCER, diagnostic, Genomics, PROGNOSIS
Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Closed loop well designs and control for extraction of subsurface geothermal power
Background Dr. Eric van Oort and his team have developed a deep, closed-loop geothermal well design to improve upon traditional enhanced geothermal systems (EGS). Dr. van Oort is the Joe J. King Chair of Engineering No. 2 and B. J. Lancaster Professorship in Petroleum Engineering and a professor at UT Austin, with primary interests in drilling/completion...
Published: 12/11/2023   |   Inventor(s): Eric van Oort, Pradeepkumar Ashok, Dongmei Chen
Keywords(s): Drilling, Geothermal, Oil & gas upstream, Renewable
Category(s): Physical sciences > Energy > Renewable, Physical sciences
Efficient and Scalable Cellular Production of Immune Functional Extracellular Vesicles
Utilizes Low-Power, Near-UV Light Induction to Produce Dendritic Cell-Derived Extracellular Vesicles for Use in Immunotherapy This simple, straightforward, and scalable production of dendritic cell-derived extracellular vesicles (DC-EVs) employs low-power, near-UV light. Dendritic cells are the most potent antigen-presenting cells and the key initiator...
Published: 7/24/2023   |   Inventor(s): Mei He
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Drug Delivery
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023   |   Inventor(s): Yu Qian, Yi Wang, Chen Chen
Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation
Category(s): Engineering and Physical Sciences
Low-cost high-temperature humidification membrane
Background Membrane humidifiers are widely used for gas humidification, where a dry gas channel and a water or humid gas channel are separated by a water-permeable membrane. During the operation, water vapor permeates through the membrane from the water or humid gas channel to the dry gas channel, driven by the relative humidity gradient across the...
Published: 12/11/2023   |   Inventor(s): Dongmei Chen, Russell Borduin, Wei Li
Keywords(s):  
Category(s): Physical sciences > Materials > Membranes
RAPIDClean: fast, accurate real-time simulations for hole cleaning operations
Problem statementImproper hole cleaning is a major cause of non-productive time (NPT) in drilling. Current hole cleaning practices are mostly based on experience, rules of thumb and simplistic calculations, and do not necessarily work as expected in all scenarios. Available models do not include parameters such as fluid compressibility, pipe rotation...
Published: 7/12/2024   |   Inventor(s): Eric van Oort, Amir Hossein Fallah, Qifan Gu, Dongmei Chen, Pradeepkumar Ashok
Keywords(s): Artificial intelligence (AI), Drilling, Oil & gas upstream
Category(s): Physical sciences > Energy > Oil & gas > Upstream oil & gas
2015-671 Underground Shafts for Hydrogen Storage
SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...
Published: 7/19/2023   |   Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove
Keywords(s): Energy & Water
Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage