Search Results - virus-like

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Self-Assembling Nanoparticles Composed of Transmembrane Peptides and Their Application for Specific Intra-Tumor Delivery of Anti-Cancer Drugs
Abstract: Peptides corresponding to transmembrane domains of a number of integral proteins were discovered to spontaneously self-assemble in aqueous solutions into stable and remarkably uniform nanoparticles. Researchers at the NCI’s Cancer and Inflammation Program have developed fully synthetic, peptide-based, virus-like nanoparticles capable...
Published: 4/8/2024   |   Inventor(s): Nadya Tarasova, Sergey Tarasov, Christopher Michejda
Keywords(s): Drug Delivery, GPCR, Hydrophobic Agent, Nanoparticle, Peptide-based Nanoparticle, Synthetic Peptide, Tarasova, VIRUS-LIKE
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Viral Like Particles Based Chikungunya Vaccines
Chikungunya virus (CHIKV) is mosquito-borne alphavirus endemic in Africa, India, and Southeast Asia. In 2013 CHIKV infection has also emerged in the Caribbean and a pandemic of CHIKV has re-emerged in the Philippines following Typhoon Haiyan. Currently, there is no vaccine available for the prevention of CHIKV infection and no specific therapy exists...
Published: 10/28/2024   |   Inventor(s): Wataru Akahata, Srinivas Rao, Gary Nabel
Keywords(s): Against, ALPHA, ALPHAVIRUS, CAPSID, Chikungunya, CHIKV, DC5BXX, Development, DNA vaccine, E1, E1-E2, E2, Envelope, Generation, Method, MODIFICATION, Modifications, PARTICLES, Patent Category - Biotechnology, PLASMID, PREVENTIVE, production, Protein, proteins, Vaccine, VBXXXX, viral, virus, VIRUS-LIKE, VLPs, VLXXXX, XHXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Diagnostics, ResearchProducts > Research Equipment
Parvovirus B19 Vaccine
Parvovirus B19 (B19V) infection causes fifth disease, a disease characterized by rashes to the face and other parts of the body that primarily affects children. However, adults can also develop fifth disease and it can lead to more severe conditions. Patients that are immunocompromised, such as those who are HIV infected, organ transplant recipients,...
Published: 10/28/2024   |   Inventor(s): Neal Young, Sachiko Kajigaya, Takashi Shimada, Ning Zhi
Keywords(s): Admin Lic Spec Review Mar-09 Active Determina, AgainstB19V, B19, B19V, BBXXXX, CAPSID, Capsids, CODON, CRADA, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, diagnostic, DNA-based, DXXXXX, GENES, Infection, Non-pennissive, PARTICLE, PARVOVIRUS, Patent Category - Biotechnology, SACGHS DNA Patent Initial Set, UA1XXX, VACCCINE, vaccines, VIRUS-LIKE, VLP-and
Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics
Parvovirus B19 Codon Optimized Structural Proteins for Vaccine and Diagnostic Applications
Parvovirus B19 (B19V) is the only known pathogenic human parvovirus. Infection by this viral pathogen can cause transient aplastic crisis in individuals with high red cell turnover, pure red cell aplasia in immunosuppressed patients, and hydrops fetalis during pregnancy. In children, B19V most commonly causes erythema infectiosum, or fifth's disease....
Published: 10/28/2024   |   Inventor(s): Neal Young, Sachiko Kajigaya, Ning Zhi
Keywords(s): Against, AgainstB19V, APPLICATION, B19V, BBXXXX, CAPSID, Cells, CODON, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPING, DNA-based, DXXXXX, Erythema infectiosum, Fifth Disease, GENES, Human parvovirus B19 infection, Hydrops fetalis, Infection, Non-pennissive, OPTIMIZED, PARTICLE, Parvovirus antenatal infection, Patent Category - Biotechnology, Pure red cell aplasia, USAGE, vaccines, VIRUS-LIKE, VLP-and
Category(s): Collaboration Sought > Collaboration, Application > Vaccines, Application > Diagnostics, TherapeuticArea > Infectious Disease