The technology presented is a breakthrough in the diagnosis of lymphatic filariasis, specifically targeting the B. malayi pathogen. It encompasses a novel soluble antigen extract used in both IgG and IgG4-based ELISA tests, aimed at detecting the presence of the filarial infection. This innovation serves as a cornerstone for a CLIA-certified reference test, established and utilized in Dr. Nutman's laboratory since the late 1980s. It offers a significant advancement in the field, particularly beneficial for remote areas where traditional PCR methods are challenging to implement, thereby facilitating more accessible point-of-care diagnostics for B. malayi infection.