Search Results - technology+classifications+%3e+screens+and+assays

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Enhanced Fluorophore Discrimination in Fluorescence Microscopy Using Multi View Spectral Unmixing with Photobleaching Dynamics

This technology allows researchers to more easily distinguish hundreds of fluorescent labels in a single image, useful for a wide variety of biological applications. Background: There are hundreds to thousands of different cells or other structures that can be labeled with fluorescent reporters in a biological sample, and then imaged on a fluorescence...

Published: 10/24/2025 | Inventor(s): Alex Valm, Yunlong Feng, Ruogu Wang

Keywords(s): Technologies

Glycosyltransferase Mutation-Activity Landscape

A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases Background: Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...

Published: 9/12/2025 | Inventor(s): Sriram Neelamegham, Ryoma Hombu

Keywords(s): Biotechnology, Diagnostic, Pharmaceutical, Technologies, Therapeutic and Vaccines

Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering

Virus-Like Particles for mRNA Delivery

Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs. Background: Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...

Published: 10/22/2025 | Inventor(s): Sriram Neelamegham, Qi Yang

Keywords(s): Featured, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Gene Therapy, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays

Luminescent Biosensor for Detection of Specific Nucleotide Sequences, Small Molecules, and Proteins at Point-of-Care

A serotonin release assay that requires no special training or expensive equipment, and produces results within hours. Background: Platelet serotonin release assay (SRA) is a widely-used clinical assay for diagnosing heparin-induced thrombocytopenia (HIT), a life-threatening complication of heparin treatment. The current SRA procedure entails sending...

Published: 5/13/2025 | Inventor(s): Stewart Loh, Harsimranjit Sekhon

Keywords(s): biomarker diagnostics, biosensor, detection, DNA nanoswitches, protein engineering, sensor, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines

A Rapid, High Content, Reagent Sparing, Fluorescent Plasmonic Assay Platform for Multiplexed Serum Antibody Detection in Lyme Disease and COVID-19

A protein microarray, in the form of a compact biochip, that can be analyzed with high sensitivity using GC-FP technology. Background: Some infectious diseases are easy to diagnose, but others are much more difficult. One example is Lyme disease (B. burgdorferi), which is caused by a slow-growing organism that takes many weeks to detect. Current...

Published: 8/13/2025 | Inventor(s): Nathaniel Cady

Keywords(s): antibodies, assays, COVID-19, nanobioscience, nanobiotechnology, screens and assays, Technologies

Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Screens and Assays, Campus > SUNY Polytechnic Institute

Novel Cryoelectrospun Scaffolds for Tissue Engineering and Methods for Manufacturing

Methods to produce 3D nanofibrous scaffolds that closely mimic soft-tissue stromal ECM using a unique cryoelectrospinning process. Background: The extracellular matrix (ECM) comprising the proteinaceous scaffold within the connective tissue is involved in regulating the function of parenchymal tissue in organs. When that becomes stiff, or fibrotic,...

Published: 5/13/2025 | Inventor(s): Susan Sharfstein, Yubing Xie, Pujhitha Ramesh, James Castracane, Melinda Larsen

Keywords(s): Technologies

Category(s): Campus > SUNY Polytechnic Institute, Technology Classifications > Screens and Assays, Campus > University at Albany

Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use

" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...

Published: 10/24/2025 | Inventor(s): Li Niu, Zhen Huang

Keywords(s): Technologies

Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Campus, Campus > University at Albany

Nucleic Acids that Encode Sodium Channels

Provides a method for screening compounds for use as anti-arrhythmic agents and other medications using mutant mammalian voltage-gated sodium channel subunit. Background: Mammalian voltage-gated sodium channels are pore-forming membrane proteins responsible for the initiation and propagation of actions in nerve, skeletal muscle, and heart cells. The...

Published: 10/24/2025 | Inventor(s): Sho-Ya Wang

Keywords(s):

Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Technology Classifications > Drug Delivery

Human Trabecular Organ-on-a-Chip Models

3D biomimetic hydrogel models of the trabecular meshwork of the eye, and a bioengineered system for modelling the conventional outflow tract. Background: Models of the trabecular meshwork have largely been 2D up until now, but research has shown that 2D models of the TM behave differently -- sometimes in complete opposition -- to 3D models. A 3D model...

Published: 5/13/2025 | Inventor(s): Samuel Herberg, Preethi Ganapathy, Haiyan Li

Keywords(s):

Category(s): Campus > Upstate Medical University, Technology Classifications > Screens and Assays

Molecular Diagnosis and Prognosis of Carcinomas

A novel molecular marker that provides a reliable prognostic indicator for DCIS breast cancer patients. Background: Ductal carcinoma in situ (DCIS) is non-invasive type of breast cancer that occurs in the milk ducts, accounting for approximately 20% of new breast cancers. DCIS is non-invasive and not life-threatening. However, patients diagnosed...

Published: 5/13/2025 | Inventor(s): Henri Tiedge

Keywords(s): breast cancer, Technologies

Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Diagnostics, Campus > SUNY Downstate Health Sciences University

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