Search Results - technology+classifications+%3e+screens+and+assays

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Use of Blood Nitric Oxide Responses as a Biomarker of Obesity and its Associated Conditions, including Allergy and Asthma

This technology offers a novel method for identifying individuals at increased risk for systemic inflammatory disorders, such as asthma, by measuring intracellular nitric oxide synthase expression in specific immune cells. Background: Asthma and other systemic inflammatory disorders often present challenges in effective diagnosis and management due...

Published: 6/12/2026 | Updated: 6/12/2026 | Inventor(s): Rauno Joks, Maja Nowakowski, Helen Durkin (Deceased)

Keywords(s): Technologies

Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Screens and Assays

Novel Test for Non-HLA-based-rejection in Organ Transplantation

Luminex-based immunoassay for prediction of non-HLA determinants of kidney transplant graft rejection Background: End-stage kidney disease, also known as end-stage renal disease or kidney failure, affects over 800,000 people in the US. It is rapidly fatal without treatment, but can be treated palliatively with dialysis or curatively by kidney transplant....

Published: 6/10/2026 | Updated: 6/8/2026 | Inventor(s): Lakshmanan Suresh, John Tomaszewski

Keywords(s): Featured, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications > Diagnostics, Technology Classifications > Screens and Assays

Production of Salivary Gland Epithelial Progenitors and Acinar Organoids

Human iPSC-based tissue engineering system to develop salivary gland epithelial progenitors used to construct acinar organoids that mimic glandular microarchitecture and function. Background: Organoids are three-dimensional cell constructs that replicate the complicated tissue microarchitecture of specialized epithelial tissues. These constructs...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s): Stelios Andreadis, Ronel Samuel, Olga Baker, Kihoon Nam

Keywords(s): Biomedical Engineering, Biotechnology, Medical Devices, Research Tool, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Screens and Assays

Fluorescent Peptides for Membrane Tension Reporting and Biomarkers

A peptide-based probe technology that enables real-time, non-invasive fluorescent detection and quantitation of cell membrane tension. Background: The 2021 Nobel Prize in Physiology or Medicine was awarded for the discovery of Piezo channels, mechanosensitive ion channels that respond to cell membrane tension, translating mechanical force directly...

Published: 5/15/2026 | Updated: 4/15/2026 | Inventor(s): Thomas Suchyna, Sergei Sukharev

Keywords(s): Featured, Research Tool, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Biological Materials

Rapid, robust, and near point-of-care saliva-based nucleic acid detection of dengue virus infections

This technology enables rapid, non-invasive detection and differentiation of all four dengue virus serotypes using saliva samples, with advanced qPCR and RT-LAMP assays, making dengue diagnosis easier, faster, and more accessible without the need for blood draws. Background: Dengue virus (DENV) is a major global health concern, with hundreds of millions...

Published: 3/9/2026 | Updated: 1/15/2026 | Inventor(s): Frank Middleton, Stephen Thomas, Adam Waickman, Timothy Rooney

Keywords(s): diagnostics, disease diagnosis, isothermal amplification (LAMP), nucleic acid, PCR, RNA viruses, saliva, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Screens and Assays, Technology Classifications > Biomedical Science and Engineering

Method to Determine Quality of Mitochondrial Cargo in Extracellular Vesicles

A novel method that measures mitochondrial membrane potential in extracellular vesicles, providing a direct readout of mitochondrial quality and utility. Background: Studies have shown that EV-mediated intercellular communication is influenced, at least in part, by the mitochondrial cargo contained within EVs. This highlights the importance of rigorous...

Published: 5/5/2026 | Updated: 1/6/2026 | Inventor(s): Barbara Alevriadou, Zahid Manzar, Hans Minderman

Keywords(s): Biotechnology, Diagnostic, Healthcare, Pharmaceutical, Research Tool, Technologies, Therapeutic and Vaccines

Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays

Enhanced Fluorophore Discrimination in Fluorescence Microscopy Using Multi View Spectral Unmixing with Photobleaching Dynamics

This technology allows researchers to more easily distinguish hundreds of fluorescent labels in a single image, useful for a wide variety of biological applications. Background: There are hundreds to thousands of different cells or other structures that can be labeled with fluorescent reporters in a biological sample, and then imaged on a fluorescence...

Published: 3/26/2026 | Updated: 10/24/2025 | Inventor(s): Alex Valm, Yunlong Feng, Ruogu Wang

Keywords(s): fluorescence, fluoroscopy, Technologies

Glycosyltransferase Mutation-Activity Landscape

A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases Background: Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...

Published: 4/16/2026 | Updated: 9/2/2025 | Inventor(s): Sriram Neelamegham, Ryoma Hombu

Keywords(s): Biotechnology, Diagnostic, Pharmaceutical, Technologies, Therapeutic and Vaccines

Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering

Virus-Like Particles for mRNA Delivery

Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs. Background: Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...

Published: 4/16/2026 | Updated: 5/19/2025 | Inventor(s): Sriram Neelamegham, Qi Yang

Keywords(s): Technologies

Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Gene Therapy, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays

Luminescent Biosensor for Detection of Specific Nucleotide Sequences, Small Molecules, and Proteins at Point-of-Care

A serotonin release assay that requires no special training or expensive equipment, and produces results within hours. Background: Platelet serotonin release assay (SRA) is a widely-used clinical assay for diagnosing heparin-induced thrombocytopenia (HIT), a life-threatening complication of heparin treatment. The current SRA procedure entails sending...

Published: 3/18/2026 | Updated: 5/13/2025 | Inventor(s): Stewart Loh, Harsimranjit Sekhon

Keywords(s): biomarker diagnostics, biosensor, detection, DNA nanoswitches, protein engineering, sensor, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines

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