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Highly Specific rAAV Capsids for Gene Therapy of Striated Muscle
Delivers Gene Therapy Specifically to Striated Muscle, Minimizing Systemic Adverse Effects These recombinant adeno-associated virus (rAAV) capsids enable improved targeting of gene therapy to striated muscle while minimizing delivery to the liver. Duchenne Muscle Disorder (DMD) is a rare genetic disorder involving progressive muscle weakness and degradation...
Published: 3/21/2025   |   Inventor(s): Hugh Sweeney, David Hammers
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Gene Therapy
Non-Caloric Carbohydrate Supplement Improves Brain Function During Aging
Delivers Monosaccharides to Bolster Protein Glycosylation and Preserve Cognitive Function in Aging Individuals This supplement supplies carbohydrates to the brain to enhance cognitive function and metabolism in aging individuals. Protein glycosylation, or the linkage of carbohydrates and proteins, is a key chemical reaction in the brain. While a healthy...
Published: 3/21/2025   |   Inventor(s): Ramon Sun, Matthew Gentry, Craig Vander Kooi
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Nutraceutical
REV-ERBα Modulators for the Treatment of Autoimmune Disorders
Activates the REV-ERBα Nuclear Receptor to Suppress TH17 Cell Development and TH17-Mediated Autoimmune and Chronic Inflammation These small molecules activate the REV-ERBα nuclear receptor to repress TH17 cell activity and treat autoimmune and chronic inflammatory disorders. TH17 cells are a subset of CD4+ T cells that play key roles in...
Published: 3/13/2025   |   Inventor(s): Laura Solt, Theodore Kamenecka, Yuanjun He, Brett Bookser, Mike Lizarzaburu
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Smart Nanoparticle-Based Cellular Transfection Tool for Therapeutic Development
Utilizes Light-Responsive Nanoparticles to Load Exosomes with Cargo Molecules Precisely and Efficiently, Maximizing Their Ability as Therapeutics This smart nanoparticle-based cellular transfection tool utilizes light-responsive nanoparticles to load therapeutic cargo molecules on demand into extracellular vesicles (EVs), or so-called exosomes, for...
Published: 2/26/2025   |   Inventor(s): Mei He
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Piperlongumine-Based PROTAC As Potent Anticancer Agent With Reduced Toxicity
Uses Piperlongumine as an E3 Ligase Ligand to Facilitate the Degradation of Cancer-Associated Proteins of Interest This naturally occurring compound with anti-cancer properties has the potential to revolutionize cancer treatment by providing tailored therapies with reduced side effects. Cancer remains a significant health issue in the United States,...
Published: 2/26/2025   |   Inventor(s): Guangrong Zheng, Daohong Zhou, Dongwen Lyu, Yaxia Yuan, Xingui Liu, Yufeng Xiao, Wanyi Hu, Jing Pei
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Adeno-Associated Virus-Based Serpin Delivery for Use as Anti-Inflammatory Gene Therapy
Recombinant Adeno-Associated Virus (rAAV) Vector Expressing Serine Proteinase Inhibitor 1 for Inhibiting Multiple Targets in the Inflammatory Cascade This recombinant AAV vector encoding a serine proteinase inhibitor (Serp-1) downregulates inflammation by targeting and inhibiting human serine proteinase enzymes. Inflammatory disorders, including lupus,...
Published: 3/28/2025   |   Inventor(s): Alfred Lewin, Alexandra Lucas, Westley Reeves, Douglas McFadden, Cristhian Ildefonso, Sriram Ambadapadi
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics
Halogenated Phenazines: Antibacterial Compounds that Prevent and Eradicate Microbial Biofilms
Antibiotic Effectively Disinfects and Eradicates Bacterial Pathogens Where Biofilm Is PresentThis series of antibacterial agents, known as the halogenated phenazines, are able to eradicate free-floating (planktonic) bacteria in addition to persistent, surface-attached bacterial biofilms against gram positive organisms such as methicillin-resistant Staphylococcus...
Published: 1/6/2025   |   Inventor(s): Shouguang Jin, Robert Huigens
Keywords(s): 2.4-debromo-1-hydroxyphenazine, 2.4-dibromo-1-acetoxyphenazine, 2-bromo-1-hydroxyphenazine, Antibacterial, antibactrial agent, Antibiotics, bromophenazine antibacterial, Disinfectants
Category(s): Technology Classifications > Human Health Care > Therapeutics
Metabolic Enhancement of T Cells for Effective Immunotherapy in Tumor Microenvironments
Enhancing Metabolic Fitness of T -Cells to Treat Central Nervous System Tumors This T cell-based immunotherapy aims to enhance anti-tumor immune response by addressing metabolic restrictions within tumor microenvironments. T cells play a crucial role in targeting immune responses and adaptive immunity. However, their ability to respond to cancer cells...
Published: 3/28/2025   |   Inventor(s): Loic Deleyrolle, Duane Mitchell, Jianping Huang, Linchun Jin
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Septal Myectomy Retractor for Aiding Cardiac Surgeons in Treating Hypertrophic Obstructive Cardiomyopathy (HOCM)
Provides Surgeons Improved and Constant Visualization, Increasing the Efficiency, Precision, Safety, and Speed of the Operation This septal myectomy retractor improves the visualization, speed and safety of the septal myectomy procedure, resulting in a more successful surgical outcome. Hypertrophic obstructive cardiomyopathy (HOCM) is a congenital...
Published: 9/16/2024   |   Inventor(s): Susan Cooke
Keywords(s):  
Category(s): Technology Classifications > Medical Devices > Equipment, Technology Classifications > Human Health Care > Therapeutics
Bacteriophage Composition for Treating Neurodegenerative Diseases
Combination Treatment of Bacteriophages and Probiotic to Remove Detrimental Bacteria from Host Gut, Remodeling Gut Microbiota and Preventing Toxic Protein Aggregation This therapeutic composition administers bacteriophages to eliminate specific bacterial strains that induce toxic protein aggregation and ultimately contribute to neurodegenerative protein...
Published: 1/31/2025   |   Inventor(s): Daniel Czyz
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Nutraceutical
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