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SPLICER: Small Molecule-Inducible Gene Expression Switches
Enables Ligand-Inducible Regulation of Gene Expression or Knockdown This small molecule-inducible gene expression based on riboswitches (SPLICER) enables precise, drug-responsive control of gene expression for safer and more flexible gene and cell therapies. In mammalian cells, alternative splicing greatly expands the diversity of RNA sequences. These...
Published: 9/2/2025   |   Inventor(s): Eric Wang, Yu Zhou
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
Autoregulated MBNL Gene Therapy for Myotonic Dystrophy
Next-Generation Gene Therapy Vectors with Tunable, Tissue-Specific, and Auto-Regulated Expression for Superior Safety and Efficacy This technology introduces recombinant adeno-associated virus (rAAV) vectors engineered to enable precise, regulated expression of therapeutic genes. Recombinant viruses can deliver therapeutic gene expression constructs...
Published: 9/2/2025   |   Inventor(s): Eric Wang, Andy Berglund, Elizabeth Delgado, Jana Jenquin, Derek Muscato, Ona McConnell, Leanne Adams, Maria Valero Quiros
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
Alternative Splicing Cassettes for AAV Gene Therapy Regulation
Uses Tissue-Specific Exons for Precise Control Therapeutic Cargo Delivery These alternative splicing cassettes use tissue specific exons to precisely deliver adeno-associated virus (AAV) cargo. AAVs are a commonly used gene therapy vector for delivering genetic material into cells. Current technology relies upon tissue specific promoters to guide and...
Published: 9/9/2025   |   Inventor(s): Eric Wang, Keril Poukalov
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
Silk Fibroin from Plodia Interpunctella and Methods for Creating Biomaterial Scaffolds
A Tunable Biomaterial Platform for Biomaterial Fabrication and Regenerative Applications Silk fibroin is a well-established biomaterial known for its strength, biocompatibility, and biodegradability. Biopolymers are investigated for biomaterial fabrication as an alternative to synthetic polymers, reducing the production of environmental pollutants...
Published: 7/14/2025   |   Inventor(s): Whitney Stoppel, Lauren Eccles, Bryce Shirk, Marisa Pacheco, Elizabeth Aikman, Jasmine McTyer
Keywords(s):  
Category(s): Technology Classifications > Engineering > Materials, Technology Classifications > Medical Devices > Others, Technology Classifications > Human Health Care > Therapeutics
CRISPR-associated Protein for Treating Neurological Diseases
Blocks Transcription of Expanded Microsatellite Repeats to Treat Muscle Degenerating DiseasesThis therapeutic precisely targets microsatellite repeats in the DNA sequence and blocks the transcription of a genetic mutation, called hexanucleotide repeat expansion, providing therapy for a variety of neurological and muscular degenerative diseases. The...
Published: 5/13/2025   |   Inventor(s): Tanvi Saxena, Belinda Pinto, Eric Wang
Keywords(s): CRISPR, Neurological Diseases, Transcription
Category(s): Technology Classifications > Human Health Care > Therapeutics
Highly Specific rAAV Capsids for Gene Therapy of Striated Muscle
Delivers Gene Therapy Specifically to Striated Muscle, Minimizing Systemic Adverse Effects These recombinant adeno-associated virus (rAAV) capsids enable improved targeting of gene therapy to striated muscle while minimizing delivery to the liver. Duchenne Muscle Disorder (DMD) is a rare genetic disorder involving progressive muscle weakness and degradation...
Published: 7/16/2025   |   Inventor(s): Hugh Sweeney, David Hammers
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Gene Therapy
Non-Caloric Carbohydrate Supplement Improves Brain Function During Aging
Delivers Monosaccharides to Bolster Protein Glycosylation and Preserve Cognitive Function in Aging Individuals This supplement supplies carbohydrates to the brain to enhance cognitive function and metabolism in aging individuals. Protein glycosylation, or the linkage of carbohydrates and proteins, is a key chemical reaction in the brain. While a healthy...
Published: 7/16/2025   |   Inventor(s): Ramon Sun, Matthew Gentry, Craig Vander Kooi
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Nutraceutical
REV-ERBα Modulators for the Treatment of Autoimmune Disorders
Activates the REV-ERBα Nuclear Receptor to Suppress TH17 Cell Development and TH17-Mediated Autoimmune and Chronic Inflammation These small molecules activate the REV-ERBα nuclear receptor to repress TH17 cell activity and treat autoimmune and chronic inflammatory disorders. TH17 cells are a subset of CD4+ T cells that play key roles in...
Published: 5/30/2025   |   Inventor(s): Laura Solt, Theodore Kamenecka, Yuanjun He, Brett Bookser, Mike Lizarzaburu
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Smart Nanoparticle-Based Cellular Transfection Tool for Therapeutic Development
Utilizes Light-Responsive Nanoparticles to Load Exosomes with Cargo Molecules Precisely and Efficiently, Maximizing Their Ability as Therapeutics This smart nanoparticle-based cellular transfection tool utilizes light-responsive nanoparticles to load therapeutic cargo molecules on demand into extracellular vesicles (EVs), or so-called exosomes, for...
Published: 5/30/2025   |   Inventor(s): Mei He
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Piperlongumine-Based PROTAC As Potent Anticancer Agent With Reduced Toxicity
Uses Piperlongumine as an E3 Ligase Ligand to Facilitate the Degradation of Cancer-Associated Proteins of Interest This naturally occurring compound with anti-cancer properties has the potential to revolutionize cancer treatment by providing tailored therapies with reduced side effects. Cancer remains a significant health issue in the United States,...
Published: 5/30/2025   |   Inventor(s): Guangrong Zheng, Daohong Zhou, Dongwen Lyu, Yaxia Yuan, Xingui Liu, Yufeng Xiao, Wanyi Hu, Jing Pei
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
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