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Halogenated Phenazines: Antibacterial Compounds that Prevent and Eradicate Microbial Biofilms
Antibiotic Effectively Disinfects and Eradicates Bacterial Pathogens Where Biofilm Is PresentThis series of antibacterial agents, known as the halogenated phenazines, are able to eradicate free-floating (planktonic) bacteria in addition to persistent, surface-attached bacterial biofilms against gram positive organisms such as methicillin-resistant Staphylococcus...
Published: 1/6/2025   |   Inventor(s): Shouguang Jin, Robert Huigens
Keywords(s): 2.4-debromo-1-hydroxyphenazine, 2.4-dibromo-1-acetoxyphenazine, 2-bromo-1-hydroxyphenazine, Antibacterial, antibactrial agent, Antibiotics, bromophenazine antibacterial, Disinfectants
Category(s): Technology Classifications > Human Health Care > Therapeutics
Metabolic Enhancement of T Cells for Effective Immunotherapy in Tumor Microenvironments
Enhancing Metabolic Fitness of T -Cells to Treat Central Nervous System Tumors This T cell-based immunotherapy aims to enhance anti-tumor immune response by addressing metabolic restrictions within tumor microenvironments. T cells play a crucial role in targeting immune responses and adaptive immunity. However, their ability to respond to cancer cells...
Published: 12/23/2024   |   Inventor(s): Loic Deleyrolle, Duane Mitchell, Jianping Huang, Linchun Jin
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Septal Myectomy Retractor for Aiding Cardiac Surgeons in Treating Hypertrophic Obstructive Cardiomyopathy (HOCM)
Provides Surgeons Improved and Constant Visualization, Increasing the Efficiency, Precision, Safety, and Speed of the Operation This septal myectomy retractor improves the visualization, speed and safety of the septal myectomy procedure, resulting in a more successful surgical outcome. Hypertrophic obstructive cardiomyopathy (HOCM) is a congenital...
Published: 9/16/2024   |   Inventor(s): Susan Cooke
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Category(s): Technology Classifications > Medical Devices > Equipment, Technology Classifications > Human Health Care > Therapeutics
Bacteriophage Composition for Treating Neurodegenerative Diseases
Combination Treatment of Bacteriophages and Probiotic to Remove Detrimental Bacteria from Host Gut, Remodeling Gut Microbiota and Preventing Toxic Protein Aggregation This therapeutic composition administers bacteriophages to eliminate specific bacterial strains that induce toxic protein aggregation and ultimately contribute to neurodegenerative protein...
Published: 8/19/2024   |   Inventor(s): Daniel Czyz
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Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Nutraceutical
Broad Spectrum Antimicrobial Compounds for Countering Antibiotic-Resistant Bacteria
Provide a Number of Promising Starting Points for Developing New Classes of Antibiotics These molecular compounds have potent antibacterial activity against a broad spectrum of Gram-negative bacteria, have no structural similarity to known antibiotics, can be readily synthesized in a few steps, and have low cytotoxicity with mammalian cells. Antibiotic...
Published: 9/4/2024   |   Inventor(s): Timothy Spicer, Louis Scampavia
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Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Others
Tissue-Specific Chimeric Constructs for Treating Duchenne Muscular Dystrophy
Delivers Micro-dystrophin and Utrophin Chimeric Constructs to the Skeletal and Cardiac Muscles, Optimizing the Gene Therapy to Each Tissue These micro-dystrophin and utrophin chimeric constructs optimize the treatment of Duchenne Muscular Dystrophy (DMD). DMD is a rare, X-chromosome-linked disorder characterized by progressive muscle degeneration and...
Published: 9/4/2024   |   Inventor(s): Hugh Sweeney
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Gene Therapy
Recombinant AAV9 Vectors with Modified Capsids for Escaping Neutralizing Human Antibodies
Amino Acid Substitutions on the Capsid Surface to Evade Neutralizing Antibodies and Improve Gene Therapy Efficacy and Safety Adeno-associated virus (AAV)-based vectors are the leading platform for the delivery of gene therapy in vivo, but have a limitation in that they need to avoid neutralizing and potentially dangerous immune response to the AAV...
Published: 9/4/2024   |   Inventor(s): Robert McKenna, Mario Mietzsch, Jane Hsi, Austin Nelson
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Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics
YAP-TEAD Core Inhibitors for Developing Cancer Therapeutics
Inhibit YAP-TEAD Interactions for the Treatment of Diseases with Altered Hippo Signaling These small molecule inhibitors target TEA domain (TEAD) proteins, with the potential to treat diseases with altered Hippo signaling, such as Hepatocellular Carcinoma (HCC) and Hepatoblastoma (HB). The Hippo signaling pathway is vital to organ growth control, stem...
Published: 9/3/2024   |   Inventor(s): Chenglong Li, Chen Zhou, Liya Pi, Chunbao Sun
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Category(s): Technology Classifications > Human Health Care > Therapeutics
Oxygen-Generating and Free Radical Scavenging Wound Dressing
Stimulates Tissue Repair by Providing Sustained Release of Oxygen and Combating Oxidative Damage This oxygen-generating and free radical scavenging biomaterial facilitates chronic wound healing, particularly diabetic foot ulcers (DFUs). This direct oxygen supply promotes cell growth and tissue repair, as well as neutralizes harmful free radicals, accelerating...
Published: 9/3/2024   |   Inventor(s): Cherie Stabler, Jiapu Liang, Nicholas Abuid
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Category(s): Technology Classifications > Human Health Care > Therapeutics
Deep Brain Stimulation Algorithm and Tool for Optimized Treatment of Movement Disorders
Predicts Personalized Stimulation Parameters in Real Time by Direct Sensing of the Patient’s Brain This therapeutic algorithm and tool processes neural signals to determine optimal and personalized deep brain stimulation (DBS) to treat and reduce symptoms of movement disorders. Deep brain stimulation (DBS) is an invasive neurological therapy...
Published: 9/3/2024   |   Inventor(s): Coralie de Hemptinne, Jackson Cagle
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
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