Search Results - hugh+sweeney

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Tissue-Specific Chimeric Constructs for Treating Duchenne Muscular Dystrophy

Delivers Micro-dystrophin and Utrophin Chimeric Constructs to the Skeletal and Cardiac Muscles, Optimizing the Gene Therapy to Each Tissue These micro-dystrophin and utrophin chimeric constructs optimize the treatment of Duchenne Muscular Dystrophy (DMD). DMD is a rare, X-chromosome-linked disorder characterized by progressive muscle degeneration and...

Published: 9/4/2024 | Inventor(s): Hugh Sweeney

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Gene Therapy

Gene Therapy to Counter Obesity in People and Companion Animals

Combines GDF15 and Myostatin Inhibitor to Treat Obesity While Preserving Muscle Mass This gene therapy combines the increased expression of GDF15 with a myostatin inhibitor to treat obesity or reduce weight while maintaining muscle mass. Obesity is a major health problem in humans and companion animals. It increases the likelihood of developing diseases...

Published: 8/21/2023 | Inventor(s): Hugh Sweeney, David Hammers

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics

Variant AAV Particles for Improved Gene Therapy

Capsid Proteins Optimize Delivery of Therapeutic Genes to Targeted Tissues These variant recombinant adeno-associated virus (rAAV) particles feature capsid surface proteins that focus delivery of therapeutic genes toward specific tissues, decreasing uptake in non-target tissues. Demand for the AAV gene therapy delivery platform is rapidly increasing...

Published: 8/9/2022 | Inventor(s): Hugh Sweeney

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics