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Mitochondrial Endoplasmic reticulum Death Inducing (MEDI) Nanomedicine

Liposomal nanoparticles containing a peptide along with molecules that disrupt critical cellular processes and lower the apoptotic threshold Background: Cancer cells exhibit a heightened apoptotic threshold, making them resistant to cell death, especially in multidrug-resistant (MDR) cancers. Mitochondrial fusion and fission processes contribute to...

Published: 9/10/2025 | Inventor(s): Mansoor Amiji, Lara Milane

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Delivery, Technology Classifications > 1. Life Science > Therapeutics

Enhanced Proteomic Profiling of Human Plasma-Derived Extracellular Vesicles through Charge-Based Fractionation to Advance Biomarker Discovery Potential

Method for enhanced isolation & analysis of plasma-derived extracellular vesicles, improved biomarker discovery & disease diagnostics Background: Current methods for isolating and analyzing extracellular vesicles (EVs) from plasma face significant challenges in achieving adequate purification from abundant plasma proteins, limiting their utility...

Published: 6/13/2025 | Inventor(s): Alexander Ivanov, Xianyi Su

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Drug Delivery, Technology Classifications > 1. Life Science > Chemistry

METHODS OF MAKING GELS AND FILMS USING CURLI NANOFIBERS

INV-21044 Background The curli system is the primary structural component of bacterial biofilm that promotes bacterial adhesion. This system is composed of highly robust amyloid nanofibers that have self-assembly properties and high resistance to harsh environmental conditions. Such unique properties make these nanofibers attractive for the production...

Published: 8/21/2025 | Inventor(s): Neel Joshi

Keywords(s):

Category(s): Technology Classifications > 2. Physical Science > Environmental/Clean tech, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Drug Delivery

Injectable, Bioadhesive Cryogel Scaffolds for Biomedical Uses

INV-19031 Background In the US, over 27 million hospital visits include invasive, therapeutic surgeries. However, despite substantial advances in gelatin, fibrin, and cyanoacrylate-based biomaterial adhesives, a robust solution with tissue integration, biomechanical integration, and wet-tissue adhesion remains a significant challenge. Hydrogels and...

Published: 8/28/2025 | Inventor(s): Sidi Bencherif, Devyesh Rana, Nasim Annabi

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Delivery, Technology Classifications > 1. Life Science > Chemistry

Oxygen as an immunological adjuvant or co-adjuvant to reinforce vaccines and immunotherapies

INV-21019 Background Vaccines are crucial to fight infections, cancer, and autoimmune conditions as they aid in generating immune response before the onset of the disease. Vaccines developed with purified molecules often do not stimulate an effective immune response as compared to the immune response generated against natural infection. Hence, adjuvants...

Published: 9/10/2024 | Inventor(s): Sidi Bencherif, Thibault Colombani

Keywords(s): Adjuvant, Biomaterials, Co-adjuvant, Oxygen, Vaccines

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Delivery, Not in use > -Pharmaceutical Composition

Cationic Polymers as Co-Drugs for chemotherapeutic Agents

Normal;border-collapse: collapse; } INV-17100 Background There are numerous anticancer chemotherapies available in the market that show cytotoxic effects along with unwanted various side effects. Researchers are trying to induce desired clinical effects at lower concentrations without much success as lowering the drug concentration has led to...

Published: 8/19/2025 | Inventor(s): Debra Auguste, Daxing Liu

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Delivery, Technology Classifications > 1. Life Science > Chemistry, Not in use > -Pharmaceutical Composition, Not in use > -Health

Hygroscopic Molecules Inhibit Collagen Nucleation

INV-20080 Background Collagen serves as the premier, load-bearing molecule in humans and animals, and is one of the major building blocks of bones, skin, muscles, tendons, and ligaments. This abundant protein helps to support and repair damaged tissue. However, the medical community has struggled to fully leverage the power of collagen for use...

Published: 8/21/2025 | Inventor(s): Jeffrey Paten

Keywords(s): Hygroscopic molecule, Nucleation Inhibitor, Proteoglycan - Glycosaminoglycan - Saccharide, Regeneration, Threshold concentration

Category(s): Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials, Technology Classifications > 1. Life Science > Drug Delivery, Not in use > -Pharmaceutical Composition, Not in use > -Biomedical Materials

Nanopreparation for Co-Delivery of Drugs and siRNA

INV-13004 Background Overexpression of p‑glycoprotein (encoded by MDR1 gene) is often associated with multidrug-resistant cancer. This protein leads to drug resistance by the efflux of chemotherapeutic drugs from the cancerous cells. Small interfering RNA (siRNA), also known as post-transcriptional gene silencer, can suppress the expression of specific...

Published: 8/19/2025 | Inventor(s): Vladimir Torchilin, Swati Biswas

Keywords(s): Delivery, Drug Delivery, Healthcare Innovation, Medical, Nanomedicine, Nanotechnology, Pharmaceutical Composition, Therapeutic

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Delivery, Not in use > -Pharmaceutical Composition, Not in use > -Nanotechnology, Not in use > -Nanomedicine, Not in use > -Health

Making Oligonucleotides Better Biopharmaceuticals with Brush Polymer-Assisted Compaction

INV-16006 Background Oligonucleotide-based gene therapy holds tremendous promise for treating a variety of disorders with a genetic basis, including cancers, neurological diseases, and metabolic conditions. However, due to difficulties including poor accumulation at target sites, removal by immune responses, nuclease degradation, and low biochemical...

Published: 8/20/2025 | Inventor(s): Ke Zhang, Xueguang Lu

Keywords(s):

Category(s): Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Delivery, Not in use > -Cancer, Not in use > -Chemistry

Biodegradable Implant for Sustained Trans-Nasal Delivery to the Brain

A sustained-release delivery vehicle for the treatment of brain diseases https://nu.technologypublisher.com/files/sites/1-s2.0-s0168365921000365-ga1_lrg.jpg Source: mrithi Padmakumar, Gregory Jones, Grishma Pawar, Olga Khorkova, Jane Hsiao, Jonghan Kim, Mansoor M. Amiji, Benjamin S. Bleier, Minimally Invasive Nasal Depot (MIND) technique...

Published: 8/20/2025 | Inventor(s): Mansoor Amiji, Smrithi Padmakumar, Benjamin Bleier

Keywords(s): Biomedical implants, Neurological Disease, Pharmaceutical Composition, Therapeutic

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Drug Delivery, Not in use > -Materials

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