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Search Results - steven+evans
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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025
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Inventor(s):
Stephen Liggett
,
Donghwa Kim
,
Yu Chen
,
Jesper Madsen
,
Steven An
Keywords(s):
Pharmaceuticals
,
Respiratory Diseases Treatment
Category(s):
Technology Classifications > Medical > Respiratory
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
Blocking Covid-19 Virus from Entering the Nares, Nasolaryngeal and Pulmonary Airways Using Ace2 Peptides
Prevents initial COVID-19 infection and neutralizes COVID-19 in an existing pulmonary infection. Background: COVID-19 remains one of the primary global health issues facing society today. The economic and social impact of the virus will likely be significant for the foreseeable future. Although effective vaccines have been developed, COVID-19 infection...
Published: 5/13/2025
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Inventor(s):
Matthew Pincus
,
Steven Evans
,
Fred Friedman
Keywords(s):
Technologies
Category(s):
Campus > SUNY Downstate Health Sciences University
,
Technology Classifications > Biomedical Science and Engineering
,
Technology Classifications > Healthcare
,
Technology Classifications > Therapeutics and Vaccines
,
Technology Classifications > Viral Vectors
Novel Bronchodilators For Treating Obstructive Lung Disease
Competitive Advantages Identified novel bronchodilators agonists that relax airway smooth muscle Could be a novel therapeutic for asthma and other obstructive lung diseases Could also be a therapeutic for other types of bronchoconstriction caused by smoke or anaphylaxis Summary Currently patients with obstructive airways diseases have...
Published: 2/19/2025
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Inventor(s):
Stephen Liggett
,
James Leahy
,
Donghwa Kim
,
Steven An
Keywords(s):
Medical Therapeutics Cell Therapy
,
Respiratory Diseases
,
Respiratory Diseases Treatment
,
Therapeutics
Category(s):
Technology Classifications > Medical > Respiratory
,
Technology Classifications > Medical > Therapeutics