Search Results - shiou+mei+linda+ooi

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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
Ultrafast Thin-Film Vapor Deposition Technique
Invention Description The demand for advanced thin-film deposition techniques has grown substantially in recent years, driven by the development of next-generation electronic, optoelectronic, and energy devices. Traditional deposition methods, such as chemical vapor deposition, molecular beam epitaxy, and physical vapor deposition, have well-established...
Published: 11/18/2025   |   Inventor(s): Feng Yan, Lin Li
Keywords(s):  
Category(s): Semiconductors, Materials & Processes, Microelectronics, Physical Science, Semiconductor Devices, Manufacturing/Construction/Mechanical
Non-Invasive Plasma Discharge Tube Device for Treating Brain Tumors
Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very effective in treating recurring tumors, and have significant clinical toxicity. A novel Plasma Discharge Tube (PDT) device has the potential to be more effective and less...
Published: 1/9/2026   |   Inventor(s): Michael Keidar, Li Lin, Vikas Soni, Xiaoliang Yao, Dayun Yan, Jonathan Sherman
Keywords(s):  
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Surgical
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 1/9/2026   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Cold atmospheric plasma-stimulated media for treating cancers
For successful cancer therapy, the most important aspect is selective eradication of cancer cells without damaging healthy cells. Cancer cells and normal cells have different thresholds for tolerance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) before cell death (apoptosis) is induced. Previously, GW researchers invented a cold...
Published: 1/9/2026   |   Inventor(s): Michael Keidar, Zhitong Chen, Xiaoqian Cheng, Li Lin
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics
A Mouse Model for Mental Disorders and Epilepsy
Current State of the Art The Neuregulin/ErbB4 signaling pathway is involved in GABAergic neurotransmission, an important inhibitory neurotransmission that regulates several processes in the central nervous system including muscle tone. Aberrant GABAergic function has been implicated in Schizophrenia, Schizo-affective disorder and in Epilepsy....
Published: 4/29/2020   |   Inventor(s): Lin Mei, Wen-Cheng Xiong
Keywords(s): Drug Discovery, Drug Testing, Epilepsy, Mouse, Schizophrenia
Category(s): Research Tools
Erbin as a Target to Regulate ErbB2 and Neuregulin Signaling
AU researchers found that erbin is a protein that interacts with ErbB2 and is critical for its expression on the surface membrane. ErbB2 becomes unstable when erbin expression is inhibited by a small interference RNA. ErbB2 is one of the most potent oncogenes in tumor genesis and metastasis. This therapeutic agent competes favorably with other drugs...
Published: 10/19/2020   |   Inventor(s): Lin Mei, Wen-Cheng Xiong, Yanmei Tao
Keywords(s):  
Category(s): Therapeutics
Novel Composition for HER2+ Cancer
The Current State of the Art: HER2 (also known as ErbB2), a receptor tyrosine kinase is overexpressed in around 25% of breast cancer cells. It is a known anti-cancer target to the monoclonal antibody, Trastuzumab. Limitation of the Current Art: However, about 20% patients develop resistance to Trastuzumab. Pertuzumab, Lapatinib, and other trastuzumab...
Published: 3/31/2022   |   Inventor(s): Lin Mei, Wen-Cheng Xiong, Cheng-Yong Shen, Yanmei Tao, Shiwen Luo
Keywords(s):  
Category(s): Therapeutics
A Rapid Modeling Technique for Custom-made and 3D-printed Orthopaedic Cast
 
Published: 11/10/2021   |   Inventor(s): Defeng Wang, Hui Lin, Lin Shi
Keywords(s):  
Category(s): Medical Devices
Fast and Accurate 3-D Registration of HR-pQCT Images
 
Published: 8/3/2021   |   Inventor(s): Lin Shi, Defeng Wang
Keywords(s):  
Category(s): Diagnostics, Medical Imaging
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