Search Results - diazeniumdiolate

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Nitric Oxide-Releasing Polysaccharide Materials
Abstract: Diazeniumdiolates comprise a diverse class of NO-releasing compounds and materials that are known to exhibit sufficient stability to be useful as therapeutics. Diazeniumdiolated compounds have been attached to polymers, substrates, and medical devices for the treatment and management of a variety of diseases including cancer, inflammation,...
Published: 5/22/2024   |   Inventor(s): Joseph Hrabie, Larry Keefer
Keywords(s): bandages, biofilm dispersal, Cellulose, Diazeniumdiolate, Nitric Oxide (NO), POLYSACCHARIDE, Wound healing
Category(s): Collaboration Sought > Materials Available, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Application > Therapeutics
Nitric Oxide Based Therapeutics for the Treatment of Lung Cancer
Abstract: Nitric oxide (NO) has a broad spectrum of actions in physiological and pathological processes.  NO-donor drugs have shown therapeutic effect in several cancer types by inducing apoptosis but the concentrations required have suggested limited clinical applicability.  For cancers such as non-small cell lung cancer where most therapies are not...
Published: 5/22/2024   |   Inventor(s): Anna Maciag, Harinath Chakrapani, Joseph Saavedra, Lucy Anderson, Larry Keefer
Keywords(s): Diazeniumdiolate, nitric oxide, NO, prodrug, Reactive Oxygen Species, ROS
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics