Search Results - harinath+chakrapani

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Nitric Oxide Based Therapeutics for the Treatment of Lung Cancer
Abstract: Nitric oxide (NO) has a broad spectrum of actions in physiological and pathological processes.  NO-donor drugs have shown therapeutic effect in several cancer types by inducing apoptosis but the concentrations required have suggested limited clinical applicability.  For cancers such as non-small cell lung cancer where most therapies are not...
Published: 5/22/2024   |   Inventor(s): Anna Maciag, Harinath Chakrapani, Joseph Saavedra, Lucy Anderson, Larry Keefer
Keywords(s): Diazeniumdiolate, nitric oxide, NO, prodrug, Reactive Oxygen Species, ROS
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics
Protected nanoparticle formulations of diazeniumdiolate class of nitric oxide prodrugs
Princeton University Invention # 10-2589 Researchers at Princeton University, Department of Chemical Engineering together with researchers at the National Institute of Cancer have developed protected nanoparticle formulations of the diazeniumdiolate class of anti-cancer lead compounds. Examples include PABA/NO O2-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl}...
Published: 3/30/2022   |   Inventor(s): Robert Prud'homme, Varun Kumar, Larry Keefer, Sam Hong, Harinath Chakrapani, Anna Maciag, Joseph Saavedra, Douglas Adamson
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals