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Methods To Generate Constrained Fluorinated Macrocycles (UCLA Case
No
. 2023-139)
UCLA researchers from the Department of Chemistry and Biochemistry have developed a
no
vel method to generate fluorinated polycycles, which may be used for downstream drug discovery and development. BACKGROUND: A significant amount of research in the field of organic chemistry centers around generating increasingly complex molecules that cyclize, forming...
Published: 5/30/2025
|
Inventor(s):
Patrick Harran
Keywords(s):
Drug Discovery
Category(s):
Chemical > Synthesis
,
Chemical > Catalysts
Modified Hyaluronic Acid Hydrogels Containing Hyaluronidase for the Time‐Controlled and Targeted Release of anti-CTLA-4 and other Therapeutic Antibodies (UCLA Case
No
. 2016-526)
UCLA researchers from the Department of Medicine have developed a
no
vel therapeutic platform for the administration of low-dose Cytotoxic T-lymphocyte Associated Protein 4 (CTLA-4) antibody for cancer immunotherapy that synergizes with conventional PD-1 therapy while sparing systemic autoimmune toxicity. BACKGROUND: Immune checkpoint inhibitor (CPI)...
Published: 5/30/2025
|
Inventor(s):
Michael Roth
,
Airi Harui
Keywords(s):
Cancer Immu
no
therapy
,
Immu
no
therapy
Category(s):
Platforms > Drug Delivery
,
Therapeutics > Immu
no
logy And Immunotherapy
,
Therapeutics > Oncology
A design to manufacture polyamide reverse osmosis membrane using molecular layer-by-layer deposition
Thin-film composite polyamide membranes, are the basis for modern commercial reverse osmosis (RO) membranes. These membranes are created through interfacial polymerization (IP) involving a trifunctional acid chloride (e.g., trimesoyl chloride, TMC, dissolved in an organic solvent) and a difunctional amine (e.g., m-phenylenediamine, MPD, dissolved in...
Published: 5/30/2025
|
Inventor(s):
Samarpan Deb Majumder
,
Xitong Liu
Keywords(s):
Category(s):
Tech
no
logy Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
,
Tech
no
logy Classifications > Industrial or Consumer Tech > Industrial Manufacturing
Robot-Aided System And Method For Diag
no
sis Of Autism Spectrum Disorder
Sensory ab
no
rmalities are reported to be central to autistic experience. The symptoms include hyposensitivity, hypersensitivity, multichannel receptivity, processing difficulties and sensory overload. Given the intensive and cumbersome nature of current methods of diagnosis, there is a need of behavior-based approach to identify the children at risk...
Published: 5/30/2025
|
Inventor(s):
Chung Hyuk Park
,
Hifza Javed
Keywords(s):
Category(s):
Tech
no
logy Classifications > Diagnostics
,
Tech
no
logy Classifications > Medical Devices > Therapeutic Devices
Tampa Neuromapping Depth Electrode
Advantages Combines recording and stimulation in a single device Reduces brain penetration and surgery time Lowers risk of hemorrhage, infection, and brain shift Enables precise brain mapping and real-time stimulation Summary Deep Brain Stimulation (DBS) helps patients with movement disorders like Parkinson’s disease by sending electrical...
Published: 5/30/2025
|
Inventor(s):
Oliver Flouty
,
Yarema Bezchlibnyk
,
Vishal Bharmauria
,
No
ur Shaheen
,
Brian Dalm
,
Can Sarica
,
Matthew Howard
,
Hiroto Kawasaki
,
Mario Zanaty
,
Alex Green
,
Andres Loza
no
Keywords(s):
Category(s):
Tech
no
logy Classifications > Medical > Neuroscience
Engineering Asymmetrically Glycosylated IgG Antibodies
Application A
no
vel method to develop asymmetrically glycosylated therapeutic monoclonal IgG antibodies for preventing and treating diseases like cancer, infectious diseases, and autoimmune disorders. Key Benefits Different IgG antibody glycoforms can be produced, each with its unique effector functions and biological and therapeutic effects. Potential...
Published: 5/30/2025
|
Inventor(s):
Eric J. Sundberg
,
Jonathan Du
,
Tala Azzam
Keywords(s):
Antibodies
,
Immu
no
logy and Inflammation Treatments
,
Microbiology and Infectious Disease Treatments
,
Oncology Treatments
Category(s):
TechPub Algolia > Therapeutics
Companion Diag
no
stic for Immunomodulatory Repair Treatments
This tech
no
logy is a diagnostic tool designed to help match patients to specific drugs or therapies to treat chronic ischemic heart failure. The platform focuses on immune cells called macrophages, which play a crucial role in the body's response to injury and disease. By promoting a specific type of macrophage known to aid healing, this system...
Published: 5/30/2025
|
Inventor(s):
Steven Goldman
,
Daniel Benson
,
Adrian Grijalva
,
Jordan Fink
,
Jordan Lancaster
,
Jennifer Koevary
,
Simar Singh
Keywords(s):
Category(s):
Tech
no
logy Classifications > Life Sciences > Diagnostics
,
Tech
no
logy Classifications > Research Tools > Screening assays
,
Tech
no
logy Classifications > Healthcare Portfolios > Heart and Vascular
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages • RBM3 upregulation reverses multiple tau phosphorylations post-TBI •
No
vel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also...
Published: 5/30/2025
|
Inventor(s):
Travis Jackson
Keywords(s):
Animal Models
,
Neuroscience
Category(s):
Tech
no
logy Classifications > Research Tools/Copyright > Animal Models
,
Tech
no
logy Classifications > Medical > Neuroscience
,
Tech
no
logy Classifications > Medical > Biotechnology
Method for Co-Localizing Two Proteins on the Inside of the Cell Membrane in Yeast
Advantages Localization of protein interactions at the cell membrane offers a more physiologically relevant model Improved screening by minimizing off-target interactions Broadly applicable and accessible tools Summary Protein-protein interactions involving membrane proteins are
no
toriously difficult to study under physiologically relevant conditions....
Published: 5/30/2025
|
Inventor(s):
Lawrence Stern
,
Michael Nelson
Keywords(s):
Drug Discovery
Category(s):
Tech
no
logy Classifications > Medical > Cell & Tissue Engineering
,
Tech
no
logy Classifications > Medical > Medical Diagnostics
,
Tech
no
logy Classifications > Medical > Biomaterials
Transgenic Foxc2-tdTomato Overexpressing Mouse Model for Study and Screening of Lymphatic Valve Development
Advantages Tissue specific Foxc2 expression with integrated tdTomato fluorescent reporter enables precise spatiotemporal visualization Enables monitoring of lymphatic valve development 1:1 co-expression of Foxc2 and tdTomato, overcoming expression variability characteristic associated with of IRES-based or viral delivery systems Single-vector...
Published: 5/30/2025
|
Inventor(s):
Joshua Scallan
Keywords(s):
Animal Models
Category(s):
Tech
no
logy Classifications > Research Tools/Copyright > Animal Models
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