Search Results - larry+keefer

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Nitric Oxide-Releasing Polysaccharide Materials
Abstract: Diazeniumdiolates comprise a diverse class of NO-releasing compounds and materials that are known to exhibit sufficient stability to be useful as therapeutics. Diazeniumdiolated compounds have been attached to polymers, substrates, and medical devices for the treatment and management of a variety of diseases including cancer, inflammation,...
Published: 5/22/2024   |   Inventor(s): Joseph Hrabie, Larry Keefer
Keywords(s): bandages, biofilm dispersal, Cellulose, Diazeniumdiolate, Nitric Oxide (NO), POLYSACCHARIDE, Wound healing
Category(s): Collaboration Sought > Materials Available, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Application > Therapeutics
PARP Inhibitor and NO-Donor Dual Prodrugs as Anticancer Agents
Abstract: Poly-ADP ribose polymerase-1 (PARP-1) is a critical enzyme involved in DNA repair.  The inhibition of PARP has emerged as a promising strategy in cancer therapy.  Numerous PARP inhibitors have been developed and advanced into clinical trials, both for use as single agents in specific patient populations and as combination therapies with various...
Published: 5/22/2024   |   Inventor(s): Anna Maciag, Joseph Saavedra, Larry Keefer, Xinhua Ji, Vandana Kumari
Keywords(s): nitric oxide, PARP, poly-ADP-ribose polymerase, prodrug
Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
Nitric Oxide-Releasing Polymers for Wound Healing
Abstract:  A number of factors can play a detrimental role in the process of wound healing such as poor nutritional status, smoking, various drugs, cancer, and diabetes.  Wound healing impairment is a challenging clinical problem with no efficacious treatments currently available.  Nitric oxide (NO) has been shown to play a role in the process of wound...
Published: 5/22/2024   |   Inventor(s): Joseph Hrabie, Larry Keefer
Keywords(s): Bioabsorption, Dermatological conditions, nitric oxide, Polyvinyl Pyrrolidone (povidone), Wound healing
Category(s): TherapeuticArea > Immunology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Dermatology, Application > Therapeutics
Nitric Oxide Based Therapeutics for the Treatment of Lung Cancer
Abstract: Nitric oxide (NO) has a broad spectrum of actions in physiological and pathological processes.  NO-donor drugs have shown therapeutic effect in several cancer types by inducing apoptosis but the concentrations required have suggested limited clinical applicability.  For cancers such as non-small cell lung cancer where most therapies are not...
Published: 5/22/2024   |   Inventor(s): Anna Maciag, Harinath Chakrapani, Joseph Saavedra, Lucy Anderson, Larry Keefer
Keywords(s): Diazeniumdiolate, nitric oxide, NO, prodrug, Reactive Oxygen Species, ROS
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics
Protected nanoparticle formulations of diazeniumdiolate class of nitric oxide prodrugs
Princeton University Invention # 10-2589 Researchers at Princeton University, Department of Chemical Engineering together with researchers at the National Institute of Cancer have developed protected nanoparticle formulations of the diazeniumdiolate class of anti-cancer lead compounds. Examples include PABA/NO O2-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl}...
Published: 3/30/2022   |   Inventor(s): Robert Prud'homme, Varun Kumar, Larry Keefer, Sam Hong, Harinath Chakrapani, Anna Maciag, Joseph Saavedra, Douglas Adamson
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals