Search Results - boris+zemelman

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A high-throughput single-cell screening platform for identifying and quantifying gene regulatory element activity
This technology enables high-throughput, single-cell screening of gene regulatory sequences using barcoded viral vectors and sequencing, allowing precise identification and quantification of active regulatory elements in specific cell types for gene therapy, disease research, and synthetic biology. Background The field of gene regulation is fundamental...
Published: 3/11/2026   |   Updated: 3/11/2026   |   Inventor(s): Boris Zemelman
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Expression system for labeling and targeting cells with elevated calcium levels
The technology describes a system for labeling and targeting cells with elevated calcium levels, such as cancer cells or activated neurons, using a CREB reporter system. This system includes a synthetic CRE enhancer linked to promoters that control the expression of genes encoding functional proteins like reporters, ion channels, or therapeutic agents,...
Published: 1/13/2026   |   Updated: 9/16/2024   |   Inventor(s): Boris Zemelman
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Therapeutics > Formulation
Targeting specific neurons for personalized next-gen therapeutics
Technology summary Neurological and cognitive disorders such as epilepsy, pain, fear and anxiety, depression, addiction, apnea and tremors can result from aberrant activity of defined subsets of neurons, including an imbalance of excitatory versus inhibitory signaling. However, it is difficult to alter neuron function selectively in the brain for research...
Published: 1/13/2026   |   Updated: 2/4/2021   |   Inventor(s): Boris Zemelman
Keywords(s): Genetic engineering, Neurodegenerative disease, Neurology, Neurosciences
Category(s): Life sciences > Therapeutics > Gene therapy