Search Results - molecular

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Molecular Detection and Viral-Load Quantification for HIV-1 Groups M, N and O, and Simian Immunodeficiency Virus-cpz (SIVcpz)
This invention provides materials, methods, and assays for detecting HIV-1 groups M and O and optionally HIV-1 group N and simian immunodeficiency virus-cpz (SIV-cpz). Specific nucleic acid primers for hybridization, amplification, and detection of HIV-1 are also provided for. The nucleic acid amplification assays can detect small concentrations of...
Published: 10/28/2024   |   Inventor(s): Danuta Pieniazek, Renu Lal
Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4XXX, DAXXXX, Detection, DXXXXX, Groups, HIV-1, M, Methods, Molecular, N, O, OID-NCHHSTP-DHPSE, REAGENTS, VLXXXX, VOXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, YBXXXX, YEXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Diagnostics, Application > Occupational Safety and Health, TherapeuticArea > Ophthalmology, Application > Therapeutics, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease
Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samples
This invention relates to assays for the detection and species-specific identification of Aspergillus fungi. Accurate clinical diagnosis of Aspergillus species has become increasingly important as certain species, such as A. terreus and A. fumigatus, are resistant to specific commonly employed antifungal compounds. Most contemporary fungal diagnostic...
Published: 10/28/2024   |   Inventor(s): Hans Hinrikson, Christine Morrison
Keywords(s): Aspergillus, CDC Docket Import, CDC Docket Import CDC Prosecuting, DAXXXX, DXXXXX, Identification, Molecular, OID-NCEZID-DFWED, Species, VKXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XCXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Occupational Safety and Health, ResearchProducts > Research Equipment, Application > Research Materials, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease
Fast Acting Molecular Probes for Real-Time In Vivo Study of Disease and Therapeutics
This technology is for fast acting molecular probes made from a fluorescent quencher molecule, a fluorophore, an enzyme cleavable oligopeptide (for example targeted by protease) and FDA-approved polyethylene glycol (PEG) as well as associated methods to identify cell activity with these probes. Proteases regulate many cell processes such as inflammation...
Published: 10/28/2024   |   Inventor(s): Seulki Lee, Lei Zhu, Xiaoyuan (Shawn) Chen
Keywords(s): AA3AXX, AA3XXX, AAXXXX, ACTING, Activity, AXXXXX, Beacon, fast, IMAGING, Molecular, PROTEASE, THEREOF, USES
Category(s): Collaboration Sought > Collaboration
Antagonist of A3 Adenosine Receptor Fluorescent Probes for the Study of Diseases that Involve A3 Signaling
This molecular probe may serve as a companion tool to identify and stratify patient populations based on the prevalence of the target A3 adenosine receptors. Small molecule drugs, A3AR-selective agonists, are currently in advanced clinical trials for the treatment of hepatocellular carcinoma, autoimmune inflammatory diseases, such as rheumatoid arthritis,...
Published: 10/28/2024   |   Inventor(s): Kenneth Jacobson
Keywords(s): A3, ADENOSINE, ANTAGONISTS, BINDING, CA1CXX, CA1XXX, CAXXXX, CXXXXX, fluorescent, IA2XXX, IA3XXX, IAXXXX, IXXXXX, Molecular, Novel, Probes, RECEPTOR
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Dermatology, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Oncology
Molecular Cloning and Characterization of SNAPIN: A Synaptic Vesicle Protein Implicated in Neurotransmitter
Neurotransmitter release is dependent on a binding complex (designated as SNAR) of three proteins, synaptic-vesicle-associated protein synaptobrevin/VAMP, syntaxin and SNAP-25 (snaptosome-associated protein-25) with results in a calcium dependent fusion between synaptic vesicles and the presynaptic terminal. SNAPIN, a neuron specific protein found...
Published: 4/8/2024   |   Inventor(s): Jeffrey Ilardi, Zu-hang Sheng
Keywords(s): ac5AXX, AC5XXX, ACXXXX, AXXXXX, CHARACTERIZATION, Cloning, implicated, Listed LPM Maddox as of 4/15/2015, Molecular, NEUROTRANSMITTER, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, Snapin:, SYNAPTIC, VESICLE
Category(s): Collaboration Sought > Licensing
New Class of Mosquitocide
This invention is a small molecule mosquitocide and method of mosquito control is based on selectively inhibiting the blood feeding of female mosquitoes. The compound inhibits nutrient processing and is lethal as shown in adult mosquito assays. Background: Numerous diseases are spread by mosquitoes, which develop resistance to chemical pesticides...
Published: 3/12/2024   |   Inventor(s): Jon Njardarson, Jun Isoe, Roger Miesfeld
Keywords(s): biology, molecular
Category(s): Technology Classifications > Veterinary Medicine
Targeted Drug Delivery to the Lower GI Tract
This technology is a new, orally administered pro-drug form of 5-aminosalicylic acid (5-ASA) that has been developed and successfully demonstrated. This invention relates generally to the field of medicine, and more specifically to methods and compositions for targeted delivery of substances to the lower GI tract. The invention has particular utility...
Published: 6/20/2024   |   Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan
Keywords(s): gastrointestinal tract, inflammation, inflammatory bowel disease, Life Sciences, molecular
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Drug Delivery
Molecular Semaphore Device for Single Molecule Detection
A major limitation of current methods to detect specific DNA sequences is the need to amplify the target DNA to detectable levels using PCR. The additional instrumentation and reagents required for PCR severely limit the portability of PCR based detection systems, greatly extend the time required for analysis, and potentially introduce significant...
Published: 2/23/2023   |   Inventor(s): Wayne Frasch, Lars Chapsky, Liyan He, Chia-Fu Chou, Frederic Zenhausern, Herb Goronkin
Keywords(s): Detection, Molecular, Nucleic Acid, Single Molecule
Category(s): Life Science (All LS Techs)