Search Results - acting

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Fast Acting Molecular Probes for Real-Time In Vivo Study of Disease and Therapeutics
This technology is for fast acting molecular probes made from a fluorescent quencher molecule, a fluorophore, an enzyme cleavable oligopeptide (for example targeted by protease) and FDA-approved polyethylene glycol (PEG) as well as associated methods to identify cell activity with these probes. Proteases regulate many cell processes such as inflammation...
Published: 10/28/2024   |   Inventor(s): Seulki Lee, Lei Zhu, Xiaoyuan (Shawn) Chen
Keywords(s): AA3AXX, AA3XXX, AAXXXX, ACTING, Activity, AXXXXX, Beacon, fast, IMAGING, Molecular, PROTEASE, THEREOF, USES
Category(s): Collaboration Sought > Collaboration
Platform Technology Using Ubiquitin to Improve the Delivery and Efficacy of Cytosolic Targeted Toxins
Targeted toxins (TT) are hybrid protein drugs consisting of ligands that bind to the surface of cancer cells and deliver polypeptide toxins that kill malignant cells by inactivating cytosolic protein synthesis and inducing cell death. A major challenge in the construction of targeted toxins is reducing the nonspecific binding of the toxin moiety to...
Published: 8/15/2024   |   Inventor(s): Stephen Leppla, Shihui Liu, Thomas Morley, Christopher Bachran
Keywords(s): ACTING, CBXXXX, CXXXXX, Cytosolic, EFFICACY, FUSIONS, IMPROVING, Targeted, TOXINS, Ubiquitin
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology