Search Results - wayne+frasch

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High Speed, High Fidelity, High Sensitivity, Nucleic Acid Detection
Technologies capable of rapid and sensitive detection of single biomolecules is continuously evolving, and is now beginning to emerge as a very promising new tool for precision detection and identification. Application areas span analytical chemical and biochemical fields, with high potential economic impact in the genomic analysis, drug discovery,...
Published: 4/14/2023   |   Inventor(s): Wayne Frasch, Justin York, David Spetzler
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices
Probes and Methods for Measuring Tandem Repeats
Telomeres, tandem repeats at the ends of chromatids, are a particular point of interest in the science of aging and cancer. Telomeric DNA is lost during cellular replication, resulting in shortened chromatid length and cessation of cell division. Many age-related diseases are linked to shortened telomeres. Conversely, many cancer cells demonstrate elongated...
Published: 2/23/2023   |   Inventor(s): Fusheng Xiong, Wayne Frasch
Keywords(s): Bioassay, biomarker, Cancer, Diagnostics, DNA nanotechnology, Early Detection, Molecular Diagnostics, Personalized medicine, PS-Bioengineering, Medical, Sensors, Singe molecule analysis, Telomerase
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools
Molecular Semaphore Device for Single Molecule Detection
A major limitation of current methods to detect specific DNA sequences is the need to amplify the target DNA to detectable levels using PCR. The additional instrumentation and reagents required for PCR severely limit the portability of PCR based detection systems, greatly extend the time required for analysis, and potentially introduce significant...
Published: 2/23/2023   |   Inventor(s): Wayne Frasch, Lars Chapsky, Liyan He, Chia-Fu Chou, Frederic Zenhausern, Herb Goronkin
Keywords(s): Detection, Molecular, Nucleic Acid, Single Molecule
Category(s): Life Science (All LS Techs)