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AUTOMATED STRUCTURAL DAMAGE DETECTION AND LOCALIZATION USING MECHANICS-INFORMED DATA ANALYSIS

VAlue proposition Structural health monitoring ensures the safety and longevity of structures like buildings and bridges. As the volume and scale of structures and the impact of their failure continue to grow, there is a need for techniques that are scalable, inexpensive, can operate passively without human intervention, and are customized for each...

Published: 8/19/2025 | Inventor(s): Vishnu Boddeti, Nizar Lajnef, Li Xuyang, Mahdi Masmoudi

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Category(s): Test and Measurement

Engineered Mucosal-Associated Invariant T (MAIT) Cells and Methods of Making and Using Thereof (UCLA Case No. 2024-055)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a novel platform and methodology for the production of mucosal-associated invariant T (MAIT) cells for therapeutic use in infectious diseases, autoimmune disorders, and cancer. BACKGROUND: Mucosal-associated invariant T (MAIT) cells are a subset of...

Published: 7/31/2025 | Inventor(s): Lili Yang

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Category(s): Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune

Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use

" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...

Published: 5/13/2025 | Inventor(s): Li Niu, Zhen Huang

Keywords(s): Technologies

Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Campus, Campus > University at Albany

Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer

Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases, such as post-stroke cellular...

Published: 5/13/2025 | Inventor(s): Li Niu, Zhen Huang, Yan Han, Congzhou Wang, Jae Seon Park

Keywords(s): RNA, Technologies

Category(s): Technology Classifications > Biomedical Science and Engineering, Campus, Campus > University at Albany

Drug Candidate for ALS

RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...

Published: 5/13/2025 | Inventor(s): Li Niu, Zhen Huang

Keywords(s): ALS, amyotrophic lateral sclerosis, aptamers, drug design, Lou Gehrig's disease, MND, motor neurone disease, RNA

Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany

A Nanotrap to Improve Survival in Severe Sepsis by Attenuating Hyperinflammation Through Hemoperfusion

This optimized nanotrap therapy in combination with a moderate antibiotic treatment resulted in a 100% survival rate in severe septic mice. Background: The mortality rates in severe sepsis patients are 30‑41%. In the U.S. alone, 1.7 million people develop sepsis on a yearly basis. Effective therapies to prevent or treat the cytokine storm or septic...

Published: 5/13/2025 | Inventor(s): Juntao Luo, Lili Wang, Changying Shi

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Category(s): Campus > Upstate Medical University, Technology Classifications > Nanotechnology

Novel Nanocarrier for Systemic and Intracellular Delivery of Biological Therapeutics

Novel nanocarrier for systemic and intracellular delivery of biological therapeutics. Background: The stability and PK profile are of general concern for in vivo applications of many peptide/protein therapeutics. Poor stability of protein drugs can trigger immunogenicity. Furthermore, peptide and protein therapeutics mostly target extracellular receptors/signaling...

Published: 5/13/2025 | Inventor(s): Juntao Luo, Changying Shi, Lili Wang

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Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Method for Vascular Regeneration and Wound Treatment

Asset/Technology Type Therapeutic Strategy Description of Invention The invention is a therapeutic approach for modulating cellular trans-differentiation and potentially angiogenesis by modulating O-glcnacylation (GlcNAc) of proteins, to treat various conditions. The inventors used existing small molecules to prove the concept in vitro and in vivo....

Published: 5/21/2025 | Inventor(s): John Cooke, Li Lai

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Category(s): Clinical Area, Clinical Area > Cardiovascular, Research Area > Heart and Vascular, Research Area > Regenerative Medicine, Technology Classifications, Technology Classifications > Other

Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay

Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...

Published: 5/30/2025 | Inventor(s): Yong Zeng, He Yan

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Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics

MEDREX (Case No. 2024-244)

Summary: UCLA researchers have developed a new software package to reconcile medication lists between different electronic health records. Background: Reconciliation is a crucial process that ensures patients’ medication lists are accurate. Transitioning between facilities using different electronic health record (EHR) systems can exacerbate...

Published: 6/2/2025 | Inventor(s): Li Zhou, Richard Korf, Cindy Liu, Edmond Wen, Advaith Gowrishetty, Jonathan Xu, Nicole Ju

Keywords(s): Software, Software & Algorithms, Software Development Tools, Software-enabled learning

Category(s): Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Software & Algorithms > Programs, Software & Algorithms > Data Analytics

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