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Search Results - lili+he
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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025
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Inventor(s):
Li Li
,
Shichao Wu
,
Jiawei Zhao
Keywords(s):
Category(s):
Technology Category > Research tools
,
Technology Category > Animal models
,
Technology Category > Biology
,
Technology Category > Diagnostic
IL-2 Independent Ultrahigh Human T Cell Activations Through Biomimetics of Immune Synapses by Graphene Oxides (UCLA Case No. 2021-068)
UCLA researchers in the Department of Materials Science and Engineering have constructed a novel graphene oxide-based platform for robust T cell activation through artificial immune synapse formation. BACKGROUND: T cells are a critical arm of the immune system with tremendous therapeutic value for immune disorders and cancer. However, modulation of...
Published: 10/2/2025
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Inventor(s):
Yu Huang
,
Lili Yang
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Engineered Mucosal-Associated Invariant T (MAIT) Cells and Methods of Making and Using Thereof (UCLA Case No. 2024-055)
UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a novel platform and methodology for the production of mucosal-associated invariant T (MAIT) cells for therapeutic use in infectious diseases, autoimmune disorders, and cancer. BACKGROUND: Mucosal-associated invariant T (MAIT) cells are a subset of...
Published: 7/31/2025
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Inventor(s):
Lili Yang
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Infectious Diseases
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Therapeutics > Immunology And Immunotherapy
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Therapeutics > Autoimmune
Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use
" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...
Published: 1/30/2026
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Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
Technologies
Category(s):
Technology Classifications > Screens and Assays
,
Technology Classifications > Research Tools and Reagents
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Campus
,
Campus > University at Albany
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases, such as post-stroke cellular...
Published: 1/30/2026
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Inventor(s):
Li Niu
,
Zhen Huang
,
Yan Han
,
Congzhou Wang
,
Jae Seon Park
Keywords(s):
RNA
,
Technologies
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus
,
Campus > University at Albany
Drug Candidate for ALS
RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...
Published: 1/30/2026
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Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
ALS
,
amyotrophic lateral sclerosis
,
aptamers
,
drug design
,
Lou Gehrig's disease
,
MND
,
motor neurone disease
,
RNA
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus > University at Albany
A Nanotrap to Improve Survival in Severe Sepsis by Attenuating Hyperinflammation Through Hemoperfusion
This optimized nanotrap therapy in combination with a moderate antibiotic treatment resulted in a 100% survival rate in severe septic mice. Background: The mortality rates in severe sepsis patients are 30‑41%. In the U.S. alone, 1.7 million people develop sepsis on a yearly basis. Effective therapies to prevent or treat the cytokine storm or septic...
Published: 1/30/2026
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Inventor(s):
Juntao Luo
,
Lili Wang
,
Changying Shi
Keywords(s):
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Nanotechnology
Novel Nanocarrier for Systemic and Intracellular Delivery of Biological Therapeutics
Novel nanocarrier for systemic and intracellular delivery of biological therapeutics. Background: The stability and PK profile are of general concern for in vivo applications of many peptide/protein therapeutics. Poor stability of protein drugs can trigger immunogenicity. Furthermore, peptide and protein therapeutics mostly target extracellular receptors/signaling...
Published: 1/30/2026
|
Inventor(s):
Juntao Luo
,
Changying Shi
,
Lili Wang
Keywords(s):
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Therapeutics and Vaccines
Method for Vascular Regeneration and Wound Treatment
Asset/Technology Type Therapeutic Strategy Description of Invention The invention is a therapeutic approach for modulating cellular trans-differentiation and potentially angiogenesis by modulating O-glcnacylation (GlcNAc) of proteins, to treat various conditions. The inventors used existing small molecules to prove the concept in vitro and in vivo....
Published: 5/21/2025
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Inventor(s):
John Cooke
,
Li Lai
Keywords(s):
Category(s):
Clinical Area
,
Clinical Area > Cardiovascular
,
Research Area > Heart and Vascular
,
Research Area > Regenerative Medicine
,
Technology Classifications
,
Technology Classifications > Other
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 1/20/2026
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Inventor(s):
Yong Zeng
,
He Yan
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Diagnostics
,
Technology Classifications > Veterinary > Diagnostics
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