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Agonistic antibodies against SLAMF7 for improved immunotherapy against human cancer
Novel Multiple Myeloma Therapy trough SIRP-alpha and SLAMF7 blockade New and first-in-class anti-SLAMF7 monoclonal antibody (Z10) Credit Shutterstock : 1878567847 UNMET NEED Multiple myeloma is a hematological cancer characterized by a clonal expansion of plasma cells. There are approximatively 2500 new cases per year in Canada and 35000...
Published: 7/2/2025   |   Inventor(s): Ming-Chao Zhong, Jin Qian, Zhenghai Tang, André Veillette
Keywords(s): Innovation
Category(s): Applications > Soins et santé > Traitement > Pharmaceutique > Oncologie, English Applications > Health and care > Treatment > Pharmaceuticals > Oncology, Secteurs > Sciences de la vie, Sectors > Life sciences, Objectifs de Développement Durable > ODD 03 : Bonne santé et bien-être, Sustainable Development Goals > Goal 03: Good Health and Well-Being
Dynamic-based Computational Drug Design Strategy for WW Domains
Understanding the relationship between protein sequence-structure and binding dynamics is not well understood. Of particular interest is the ability to relate foldability and function of a protein and the ability to characterize how foldability and binding change based on mutations in the protein sequence. WW domains are one of the most abundant independently...
Published: 6/3/2025   |   Inventor(s): Jin Lu, Ismail Can Kazan, Sefika Banu Ozkan
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Design of Wireless Interrogated MEMS Capacitive Intraocular Pressure Sensors
Advantages Detects intraocular pressure changes with sub-0.1 mmHg resolution for superior clinical precision. Battery-free wireless design enables safe, continuous monitoring through inductive telemetry technology. Biocompatible materials ensure long-term implantation with minimal risk and high patient safety. MEMS-based fabrication allows cost-effective,...
Published: 6/3/2025   |   Inventor(s): Ramesh Ayyala, Liguan Li, Jing Wang
Keywords(s): Ophthalmic Equipment, Ophthalmology
Category(s): Technology Classifications > Medical > Ophthalmology
Frequency Alteration and Performance Enhancement of a Resonant MEMS Device and a Resonant MEMS Array
Advantages Improves resonator precision and quality using localized Joule heating Enables post-fabrication tuning without redesign or full re-manufacture Enhances performance by lowering motional resistance and boosting Q factor Works with a wide range of MEMS materials and device shapes Summary MEMS resonators are widely used in precision...
Published: 6/20/2025   |   Inventor(s): Ugur Guneroglu, Jing Wang, Adnan Zaman
Keywords(s): Electronics, Piezoelectric, Semiconductors
Category(s): Technology Classifications > Engineering > Electrical Engineering, Technology Classifications > Engineering > Mechanical Engineering
Piperlongumine-Based PROTAC As Potent Anticancer Agent With Reduced Toxicity
Uses Piperlongumine as an E3 Ligase Ligand to Facilitate the Degradation of Cancer-Associated Proteins of Interest This naturally occurring compound with anti-cancer properties has the potential to revolutionize cancer treatment by providing tailored therapies with reduced side effects. Cancer remains a significant health issue in the United States,...
Published: 5/30/2025   |   Inventor(s): Guangrong Zheng, Daohong Zhou, Dongwen Lyu, Yaxia Yuan, Xingui Liu, Yufeng Xiao, Wanyi Hu, Jing Pei
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Glycan Binding HTS Platform for Drug Development
Description This technology is an innovative glycan library platform for drug development. This is a DNA-encoded glycan library (DEGL) platform demonstrating higher content and throughput potential. Scientists can utilize this platform to identify and study specific glycan structures through unique DNA barcodes, facilitating drug screening and lead...
Published: 2/21/2025   |   Inventor(s): George Peng Wang, Muhammed Kondengaden, Aishwarya Parameswaran, Jing Song, Liuqing Wen, Huajie Zhang
Keywords(s):  
Category(s): Assay, Research Tool
Fabrication Method for Hexagonal Boron Nitride Layers
Computer memory devices may employ any of various mechanisms for storing data, e.g., using memory cells each of which may be programmed to be in any of two or more states. Non-volatile memory includes memory cells each of which operates by changing the resistance across an active switching layer, e.g., an insulator, through the formation of conductive...
Published: 2/13/2025   |   Inventor(s): Ivan Sanchez Esqueda, Jing Xie, Robert Nemanich, Ali Yekta
Keywords(s): Electronics, Fabrication, Materials and Electronics, Memory, Nanofabrication, Nanostructure, PS-Advanced Materials and Nanotechnology, Resistive Memory
Category(s): Advanced Materials/Nanotechnology, Physical Science, Semiconductors, Materials & Processes
COLD SINTERED MXENE CERAMICS
PAGE SUMMARY This technology introduces a novel method for integrating 2D materials into ceramics without high-temperature degradation, enhancing their electrical and mechanical properties. It was jointly developed by leading researchers Yury Gogotsi at Drexel University and Clive Randall at Penn State University and is available for licensing. Nanocomposites...
Published: 2/20/2025   |   Inventor(s): Yury Gogotsi, Babak Anasori, Benjamin Legum, Pavel Lelyukh, Jing Guo, Ke Wang, Clive Randall
Keywords(s):  
Category(s): Advanced Materials & Chemicals, MXenes
Rare-Earth-Element Free Yellow Phosphors for White Light-Emitting Diodes
​ Yellow phosphor emits white light when excited with the 460 nm blue lighting. The blue LED (left half; top) when coated with dispersed yellow phosphor (right half; top) emits white light. Invention Summary: Despite their low energy consumption and higher efficiency, white light-emitting diodes made of blue chip coupled with yellow phosphor...
Published: 12/4/2024   |   Inventor(s): Jing Li, Zhichao Hu, Qihan Gong
Keywords(s): Electronics, LEDs
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Electronics/Semiconductor
Hybrid Lighting Phosphors with High Quantum Efficiency, and Enhanced Thermal and Photostability
​ This rare-earth element-free invention can be used in LEDs to generate the entire visible spectrum​ Invention Summary: The use of rare earth elements in the phosphor coating of light-emitting diodes (LEDs) and compact fluorescent lamps (CFLs) raises environmental...
Published: 12/4/2024   |   Inventor(s): Jing Li, Yang Fang, Wei Liu
Keywords(s): LEDs, Photonics and photovoltaics
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Electronics/Semiconductor
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