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Controlled Tunnel Gap Device for Sequencing Polymers
To reduce costs and increase the availability of personalized genomics new approaches to DNA sequencing are required. Nanopore sequencing is one proposed technique. In nanopore sequencing, DNA molecules are forced through a tiny aperture by electrophoresis. As the individual bases transit the nanopore, their identity can be determined, in theory, by...
Published: 8/22/2024   |   Inventor(s): Stuart Lindsay, Shuai Chang, Jin He, Peiming Zhang, Shuo Huang
Keywords(s): Bio-Technology
Category(s): Life Science (All LS Techs)
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government’s pursuit of the “Thousand Dollar Genome” and the “X Prize” goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will...
Published: 8/22/2024   |   Inventor(s): Stuart Lindsay, Colin Nuckolls, Jinyao Tang, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Proteomic Assays/Reagents/Tools
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government's pursuit of the "Thousand Dollar Genome" and the "X Prize" goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will open a new...
Published: 8/22/2024   |   Inventor(s): Stuart Lindsay, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
Interleukin-27 Producing B-Cell Population and Uses Thereof
Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees to advance the production and uses of interleukin-27 (IL-27) producing B-regulatory cell (i27-Breg) therapy for immune related autoimmune disorders. These disorders include but are not limited, to age-related macular degeneration (AMD), graft-versus-host...
Published: 8/14/2024   |   Inventor(s): Charles Egwuagu, Jin Choi
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Neurology, TherapeuticArea > Immunology
Improved resuscitation in hemorrhagic shock using polyethelyne glycol modified albumin (PEG-Alb).
Background Capillary leakage of important ions and proteins, such as albumin from blood vessels can lead to a buildup of fluid in interstitial space (organ swelling) as well as hypoperfusion of organs. Capillary leak (CL) is a central component of multiorgan failure and a secondary component to severe sepsis caused by bacterial or viral infections,...
Published: 5/9/2024   |   Inventor(s): Ragheb Assaly, J Dignam, Joseph Shapiro
Keywords(s):  
Category(s): Inflammation & Immunity
High-Speed Computational System for Big Data Processing
Computational architecture to address the challenge of large data volume in search engines. Problem: Executing big data applications such as search engines is energy expensive and requires high throughput data processing. Part of the inefficiency data comes from accessing data between local storage and memory and cloud storage. Additionally, the ratio...
Published: 5/3/2024   |   Inventor(s): Jing Li, Jialiang Zhang
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Data Science, Software
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Computer Information Systems
Combating Opioid-Induced Respiratory Depression Using Setmelanotide
The opioid crisis is a serious public health crisis in the United States. Mortality from opioid overdose increased by roughly ten times from 1999 to 2021. The primary cause of death is due to opioid-induced respiratory depression (OIRD). Currently, Naloxone and Nalmefene are actively used to reverse OIRD in emergency settings and by first responders....
Published: 7/30/2024   |   Inventor(s): Vsevolod Polotsky, David Mendelowitz, O Aung, Mateus Ramos Amorim, Joan Escobar
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules, Technology Classifications > Therapeutics > Repurposed Drugs
A Wearable On-Eyelid Sensor Network for Vestibular-Ocular Reflex Assessment (Case No. 2023-166)
Summary: UCLA researchers in the Department of Bioengineering have developed an ultra-thin, self-powered, waterproof, biocompatible, and sensitive on-eyelid sensor network for wireless eye movement detection, enhancing vestibular diagnostics. Background: The human balance system relies on the interaction of the vestibular system with the visual and...
Published: 4/19/2024   |   Inventor(s): Jun Chen, Jing Xu
Keywords(s): diseases of the eye, eye motion, eye movement disorders, eye tracking, gaze fixation, magnetoelastic effect, magnetoelastic sensor, on-eyelid sensor, peripheral vestibular disorders, vestibular pathology assessment, Vestibular-Ocular Reflex (VOR)
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics, Electrical, Electrical > Signal Processing, Electrical > Sensors
Slow-wave hybrid magnonics based on interacting magnons and spoof surface plasmon polaritons
INV-23082 A novel slow-wave method for efficiently coupling spin waves with electromagnetic waves without compromising operational bandwidth. Background: Spin wave transduction is a crucial element in the field of magnonics, a branch of a family of technologies analogous to electronics that uses spin waves (magnons) instead of electrical currents...
Published: 9/10/2024   |   Inventor(s): Xufeng Zhang, Jing Xu
Keywords(s):  
Category(s): Technology Classifications > 2. Physical Science, Technology Classifications > 2. Physical Science > Electronics/Semiconductors, Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials, Technology Classifications > 3. Computer Science > Quantum Computing
Antimicrobial Antibody Panels for Lung Cancer Detection
the second most common cancer in both men and women and the leading cause of cancer death in the US. Although there are risk factors for lung cancer, such as smoking, there are many cases where the patient never smoked. Because of this, there is growing interest in investigating the lung microbiota and how that may promote or prevent disease. Yearly...
Published: 8/2/2023   |   Inventor(s): Mahasish Shome, Ji Qiu, Yunro Chung, Joshua LaBaer
Keywords(s):  
Category(s): Cancer, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
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