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Search Results - jianxin+chen
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Fully Human Antibody Targeting Tumor Necrosis Factor Receptor Type 2 (TNFR2) for Cancer Immunotherapy
Abstract: Tumor necrosis factor receptor type 2 (TNFR2)-expressing regulatory T cells (Tregs), present in the tumor microenvironment, play an important role in tumor immune evasion. TNFR2 plays a crucial role in stimulating the activation and proliferation of Tregs, a major checkpoint of antitumor immune responses. In addition to its expression on Tregs,...
Published: 5/22/2024
|
Inventor(s):
Joost Oppenheim
,
Dimiter Dimitrov
,
De Yang
,
Xin Chen
,
Zhongyu Zhu
Keywords(s):
ADCC
,
ANTIBODY
,
Antibody-dependent Cellular Cytotoxicity
,
CANCER
,
Immunotherapy
,
Oppenheim
,
TNFR2
,
Tregs
,
Tumor Necrosis Factor Receptor Type 2
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Oncology
Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024
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Inventor(s):
George Sutphin
,
Samuel Freitas
,
Megha Padi
,
Chen Chen
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Biomarkers
,
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools > Screening assays
,
Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023
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Inventor(s):
Yu Qian
,
Yi Wang
,
Chen Chen
Keywords(s):
autonomous drone
,
flight control
,
image processing
,
railroad track inspection
,
self-navigation
Category(s):
Engineering and Physical Sciences
Engineered globular endolysin, a highly potent antibacterial enzyme for multidrug resistant Gram-negative bacteria
[Licensing negotiation in progress] [Invitation for Expression of Interest- Deadline 2 July 2021] We are inviting expressions of interest (EoI) for commercializing “Engineered Globular Endolysin, a Highly Potent Antibacterial Enzyme for Multidrug Resistant Gram-Negative Bacteria” technology. The innovation is developed by Professor XIA...
Published: 10/17/2023
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Inventor(s):
Jiang XIA
,
Shui Yee LEUNG
,
Xi CHEN
,
Miao LIU
Keywords(s):
Category(s):
Biotechnology
,
Therapeutics
2015-671 Underground Shafts for Hydrogen Storage
SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...
Published: 7/19/2023
|
Inventor(s):
Adrienne Lavine
,
Hossein Kavehpour
,
Dante Simonetti
,
Richard Wirz
,
Chen Chen
,
Gabriela Bran
,
Gopinath Warrier
,
Hamarz Aryafar
,
Jonathon Kennedy
,
Joshua Jordan
,
Keith Lovegrove
Keywords(s):
Energy & Water
Category(s):
Energy & Environment > Energy Generation > Solar
,
Energy & Environment > Energy Storage
2018-748 A Method for Digital Pathology Using Augmented Reality
SUMMARYUCLA researchers in the Departments of Electrical Engineering and Computer Engineering have developed a novel method for automated image analysis of digital pathology slides.BACKGROUNDDigital pathology is an extremely powerful imaging tool in cancer research and clinical practices. Advancements in whole slide scanners has enabled complete digitization...
Published: 9/17/2024
|
Inventor(s):
Bahram Jalali
,
Antoni Ribas
,
Madhuri Suthar
,
Cejo Lonappan
,
Jia Chen
,
Theodore Nowicki
Keywords(s):
Life Science Research Tools
,
Medical Devices and Materials
,
Medical Imaging
,
Microscopy And Imaging
,
Monitoring And Recording Systems
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Microscopy And Imaging
,
Medical Devices
,
Medical Devices > Medical Imaging
,
Medical Devices > Monitoring And Recording Systems
Bi-Functional RGD Peptide and a Co-Signaling Mechanism to Promote Therapeutic Angiogenesis
Bi-Functional RGD Peptide to Promote Therapeutic Angiogenesis, Treat Ischemic Diseases Technology: While previous studies have focused on the identification of biological ligands to improve the functions of endothelial cells, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide functionalized...
Published: 3/23/2023
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Inventor(s):
Chung-Jen (James) Chou
,
Ying Mei
,
Jia Jia
Keywords(s):
Category(s):
BioPharma
Graphene Ceramic Composites for Hydrogen Separation Membranes
The Clemson composite membrane provides robust hydrogen separation from mixed gas streams by transport mechanisms based on mixed ionic (proton) and electronic conduction. The global hydrogen generation market has been valued at $115 Billion as of 2017 and is expected to rise to $154 billion by 2022. This growth is influenced by hydrogen’s use...
Published: 11/9/2022
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Inventor(s):
Kyle Brinkman
,
Siwei Wang
,
Jian He
,
Yufei Liu
,
Fanglin Chen
,
Shumin Fang
Keywords(s):
Category(s):
Advanced Materials
Graphene-Ceramic Composite for Hydrogen Separation Membranes
Reference #01277The University of South Carolina is offering licensing opportunities for graphene-ceramic composites used for hydrogen separation membranes.Background:Hydrogen is produced in large quantities worldwide for applications in the fertilizer and petroleum industries. Metal-ceramic cermet composites such as nickel-ceramics have been widely...
Published: 4/19/2022
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Inventor(s):
Fanglin Chen
,
Shumin Fang
,
Kyle Brinkman
,
Siwei Wang
,
Jian He
,
Yufei Liu
Keywords(s):
Category(s):
Engineering and Physical Sciences
,
Chemistry and Biochemistry
,
Energy
Broad Tunable Quantum Cascade Lasers with Multiple Strongly coupled Upper Laser States
Princeton Docket # 10-2616 Broadly tunable QC lasers are ideal candidates for multi-analyte mid-infrared spectroscopy application. However, the maximum tuning range is usually limited by the inherently narrow gain spectrum of intersubband transitions. Princeton researchers have developed a ¿continuum-to-bound¿ QC laser, with two lower injector...
Published: 3/30/2022
|
Inventor(s):
Yu Yao
,
William Charles
,
Jianxin Chen
,
Claire Gmachl
Keywords(s):
Category(s):
Mechanical/Electrical Engineering