Search Results - jian+he

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The Problem: The prolific use of mobile devices has driven demand for secure, convenient mounting solutions across various environments. Traditional docking stations often rely on adhesive pads and mechanical clamps can be bulky, not universally compatible, and difficult to operate with one hand. Suction based holders are prone to stability issues....

Published: 8/4/2025 | Inventor(s): Greg Berkeley, Ian Shen

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Category(s): Technology Classifications, Technology Classifications > Lifestyle & Leisure

Boosting Stem Cell Editing with CRISPR Nanoparticles

Invention Summary: Gene editing in hematopoietic stem cells (HSCs) holds immense promise for curing genetic blood disorders such as sickle cell anemia and β-thalassemia. However, a major hurdle lies in the safe, efficient, and targeted delivery of CRISPR/Cas9 systems into these delicate stem cells. There is a critical need for innovative...

Published: 8/12/2025 | Inventor(s): Jinglin Fu, Jian Huang

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Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics

Methods for Rapid, Scalable, Amplified Nucleic Acid Detection In Situ

Brief Description: The present invention provides novel methods for exponential amplification of nucleic acid's fluorescence in situ hybridization (FISH) signal with high sensitivity and specificity. The present method thereby allows for FISH to be used in high-throughput screening methods and diagnostics. In one aspect, the invention comprises...

Published: 7/9/2025 | Inventor(s): Arjun Raj, Ian Dardani, Benjamin Emert, Sara Rouhanifard

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Category(s): Technology Classifications > Research Tools & Reagents

Antimicrobial Photocatalytic Films for Packaging and Surfaces

THE CHALLENGE A major business challenge in the food packaging industry lies in developing cost-effective, scalable antimicrobial solutions that meet both regulatory standards and consumer expectations for safety and sustainability. While existing technologies like synthetic preservatives, UV-activated coatings, and metal nanoparticles offer short-term...

Published: 7/3/2025 | Inventor(s): Haibo Huang, Danmeng Shuai, Young-Teck Kim, Jian Wu, Andrea Johnson

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Category(s): Technology Classifications > Biotechnology, Technology Classifications > Consumer Products, Technology Classifications > Electronics

Biodegradable Polymers for Gene Delivery

Invention Summary: In gene therapy, a key challenge is delivering therapeutic genes to target cells, which requires gene delivery vectors. While viral vectors are effective, they pose risks such as immune responses and toxicity. Non-viral vectors, particularly cationic polymers, are preferred for their safety, cost-effectiveness, and high...

Published: 8/12/2025 | Inventor(s): Adam Gormley, David Radford, Prajakatta Mulay, Jia Niu, Brayan Rondon

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Category(s): Technology Classifications > Agriculture, Technology Classifications, Technology Classifications > Physical Sciences & Engineering

SAMURI-Self-Administered Multiplex Universal Radiation Indicator

SAMURI is an innovative point-of-care biodosimetry screening kit designed to detect and measure specific proteins and transcripts within leukocytes that serve as radiation biomarkers. The kit utilizes a vertical flow immunoassay, integrating all the necessary components for sample collection, preparation, bioassay, detection, automated data analysis,...

Published: 6/4/2025 | Inventor(s): Frederic Zenhausern, Jerome Lacombe, Sally Amundson, Jian Gu, Helen Turner, Igor Shuryak, Michael Price

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Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic

Batch Processing Automation for Imaris Stitcher (Case No. 2025-089)

Summary: Researchers in UCLA’s Department of Neurobiology have developed a novel software tool that enhances the capabilities of Imaris Stitcher. The tool enables batch processing and automated execution of multiple image stitching jobs, significantly improving workflow efficiency and reducing hands-on time. This results in readily available,...

Published: 7/14/2025 | Inventor(s): Ian Bowman, Mitchell Rudd, Hong Wei Dong

Keywords(s): 3D tissue imaging, 3D ultrasound imaging, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, artificial-intelligent materials, bioimaging, Cell Counting/Imaging, cell imaging, cell mapping, computational imaging, Data Acquisition, Data Aggregator, Data Analytics, Data Recovery, Data Structure, Fluorescence Microscope, histopathology images, Image Analysis, image restoration, image signal processing, Imaging, Magnetic Resonance Imaging, Medical artificial intelligence (AI), Medical Imaging, Microscope, Microscopy, Microscopy And Imaging, Molecular Imaging, multi-contrast imaging, Neuroimaging, non-invasive imaging, pathology image analysis, Phase-Contrast Imaging, three dimensional imaging, volumetric image

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing

RNA-aptamer-mediated Bacteriophage Purification

A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes. Background: Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...

Published: 5/13/2025 | Inventor(s): Ing-Nang Wang, Hua Shi, Jia Sheng, Alan Chen

Keywords(s): bacteriophage purification, phage purification, phage therapy, RNA aptamer, Technologies

Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines

Drug Discovery Based on Surface-Enhanced Raman Spectroscopy (SERS)

Enables drug discovery without introducing modifications to the molecules, while lowering costs by requiring only small amounts of the tested molecules. Background: Surface-enhanced Raman spectroscopy (SERS) is a novel, label-free, sensitive, specific, fast, and relatively inexpensive tool for drug discovery. It offers the potential to detect and...

Published: 5/13/2025 | Inventor(s): Igor Lednev, Lamyaa Almehmadi, Jia Sheng

Keywords(s): Raman spectroscopy, RNA, RNA chemistry, TAF, Technologies

Category(s): Campus > University at Albany, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay

Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...

Published: 5/30/2025 | Inventor(s): Yong Zeng, He Yan

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Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics

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