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RNA-aptamer-mediated Bacteriophage Purification

A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes. Background: Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...

Published: 4/1/2025 | Inventor(s): Ing-Nang Wang, Hua Shi, Jia Sheng, Alan Chen

Keywords(s): bacteriophage purification, phage purification, phage therapy, RNA aptamer, Technologies

Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines

Drug Discovery Based on Surface-Enhanced Raman Spectroscopy (SERS)

Enables drug discovery without introducing modifications to the molecules, while lowering costs by requiring only small amounts of the tested molecules. Background: Surface-enhanced Raman spectroscopy (SERS) is a novel, label-free, sensitive, specific, fast, and relatively inexpensive tool for drug discovery. It offers the potential to detect and...

Published: 4/1/2025 | Inventor(s): Igor Lednev, Lamyaa Almehmadi, Jia Sheng

Keywords(s): Raman spectroscopy, RNA, RNA chemistry, TAF, Technologies

Category(s): Campus > University at Albany, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay

Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...

Published: 3/4/2025 | Inventor(s): Yong Zeng, He Yan

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics

Nanoparticles for Precise & Targeted Treatment of Neurological Conditions

Problem: Acute ischemic stroke (AIS) is the second leading cause of death worldwide, affecting around 600,000 Americans annually. However, pharmacological treatment of AIS is difficult due to ineffective and nonspecific targeting to blood brain barrier epitopes via intravenous administration. Over 100 drugs have been tried and failed in clinical trials...

Published: 2/20/2025 | Inventor(s): Oscar Marcos Contreras, Jacob Brenner, Vladimir Muzykantov, Jia Nong, Patrick Glassman, Drew Weissman, Sahiley Reyes-Esteves

Keywords(s): Drug Delivery, Inflammation, Nanotechnology, Neurology

Category(s): Technology Classifications > Therapeutics

Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations

The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and...