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HIGH-THROUGHPUT FORCE-DEPENDENT CELLULAR RESPONSE ASSAY USING SPECTRALLY ENCODED SMART BEADS

HIGH-THROUGHPUT FORCE-DEPENDENT CELLULAR RESPONSE ASSAY USING SPECTRALLY ENCODED SMART BEADS Researchers at Stanford have developed a technology that uses biomechanical force to initiate T-cell triggering in a high throughput method, facilitating the exploration of the force- and sequence-dependent landscape of T-cell responses. Adaptive immunity...

Published: 3/17/2023 | Inventor(s): Xiang Zhao, Adam White, Polly Fordyce, Yinnian Feng, K Garcia

Keywords(s): Catch Bond, High-Throughput Mechanobiology, Ligand Discrimination, Mechanotransduction, Single-Cell Microfluidics, Spectrally Encoded Beads, T-Cell Activation, T-Cell Biophysics, T-Cell Receptor

Category(s): Technology Classifications > Biology

Recombinant Modified Bacillus anthracis Protective Antigen for Use in Vaccines

This invention relates to improved methods of preparing Bacillus anthracis protective antigen (PA) for use in vaccines. PA is a secreted, non-toxic protein with a molecular weight of 83 KDa. PA is a major component of the currently licensed human vaccine (Anthrax Vaccine Adsorbed, AVA). Although the licensed human vaccine has been shown to be effective...

Published: 7/25/2024 | Inventor(s): John Robbins, Stephen Leppla, Rachel Schneerson, M Rosovitz

Keywords(s): Anthrax, ANTIGEN, Chromosome 18 ring, Chymotrypsin-Sensitive, CREATION, Cutaneous anthrax, DAXXXX, DBXXXX, DC4XXX, DC6XXX, DCXXXX, DDXXXX, DELETIONS, DXXXXX, Furin-Cleavage..., Loop, MOLECULE, Protective, R 18, recombinant, rPA, STABLE, UAXXXX

Category(s): Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines

Self-Calibrating Chemical & Bio Sensor

With the rise of non-state actors posing a threat to various nations coupled with the massive amount of information available, the world has seen an increased risk of chemical warfare being used against civilians. Once reserved for the top chemists, the synthesis of chemical agents such as Sarin, VX, mustard gas, and arsine has become more available...

Published: 7/30/2024 | Inventor(s): David Nagel, R McGill, Patrick Mills, Rekha Pai

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Industrial Manufacturing, Technology Classifications > Computers Electronics & Software > Sensors

Cost-Effective Single-Step Process for the Catalytic Conversion of Methane to Methanol/Formaldehyde

Unmet Need: Currently there is no technology available in the market capable of producing Dimethyl Ether (DME) from methane in a single reactor. DME is an attractive substitute for diesel due to its high cetane number, which is a measure of its ignitibility in compression ignition engines. In addition, DME’s quiet combustion and inability to form...

Published: 5/25/2023 | Inventor(s): Su Ha, M Norton, Oscar Marin Flores

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Category(s): Technologies > Health & Well-being > Chemistry, Technologies > Energy & Environment > Energy

Pharmacological EZH2 inhibition enhances cancer cell sensitivity to genotoxic insults through suppressing DNA damage repair

HSC-1535 Pharmacological EZH2 inhibition enhances cancer cell sensitivity to genotoxic insults through suppressing DNA damage repairKexin Xu: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.Myles Brown: Center for Functional Cancer Epigenetics and Department of Medical Oncology,...

Published: 5/28/2024 | Inventor(s): Kexin Xu, Myles Brown, Chen-Hao Chen, Xiaole Shirley Liu, CPRIT

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Category(s): Clinical Specialty > Oncology, Clinical Specialty > Radiology, Diagnostics > Assay, Life Sciences Research Tools > Biomarkers

Electrical Ion Sensors Based on MOSCs

Although metal organic frameworks (MOFs) have proven to be effective for electronic ion sensing, they lack key desirable characteristics such as solution processability due to their insolubility in most common solvents. Metal-organic supercontainers (MOSCs) have a significant advantage over MOFs, as they can be readily dispersed in solution while retaining...

Published: 5/8/2020 | Inventor(s): Zhenqiang Wang, Zhen Zhang, Nathan Netzer, Indrek Must, Yupu Qiao, Shi-Li Zhang

Keywords(s): Chemistry, Electrical Engineering, Environmental Monitoring, Ion Detection

Category(s): Chemistry, Health Care, Electrical Engineering, Environmental Monitoring, Agriculture, Ion Detection, Materials Science, Sensors

Micro Faraday-Element Array Detector for Ion Mobility Spectroscopy

The novel ion mobility spectrometry (IMS) includes a drift tube having a collecting surface covering a collecting area at one end of the tube. The surface comprises a plurality of closely spaced conductive elements on a non-conductive substrate, each conductive element being electrically insulated from each other element. A plurality of capacitive transimpedance...

Published: 3/12/2024 | Inventor(s): M Denton, Roger Sperline, Christopher Gresham, Phillip Rodacy

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Category(s): Technology Classifications > Engineering & Physical Sciences, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Mass Spectrometry

Differential Transimpedance Amplifier Circuit for Correlated Differential Amplification

Researchers at the University of Arizona have created a differential transimpedance amplifier circuit for correlated differential amplification. The amplifier circuit increases electronic signal-to-noise ratio in charge detection circuits designed for the detection of very small quantities of electrical charge and/or very weak electromagnetic waves....

Published: 3/12/2024 | Inventor(s): M Denton, Roger Sperline, Christopher Gresham

Keywords(s):

Reflective Multistable LCD

Reference Number:1653 Background Liquid crystal displays (LCDs) dominate the market for flat panel electronic displays due to their size, low-drive voltage and low-power consumption. They have been used in calculators, watches and simple digital displays since the 1970s, but more recently their use has extended to mobile phones, laptop computers,...

Published: 2/21/2014 | Inventor(s): N Mottram, Andrew Davidson

Keywords(s): Optoelectronics

Category(s): Communications