Search Results - immunology%2finflammation

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Application An intra-articular alignment guide for ankle replacement system to treat ankle arthritis. Key Benefits Less invasive method that does not require drilling a hole through the heel for Inbone II tibial stem placement. More convenient to use compared to Inbone II frame and foot holder to find the correct alignment. Market Summary Approximately...

Published: 7/30/2024 | Inventor(s): Rishin Kadakia

Keywords(s): Hospital and Surgery, Immunology/Inflammation

Category(s): TechPub Algolia > Medical Device

Novel Piperidine-Amide Derivatives as CXCR4 Modulators

Application A new class of CXCR4 modulators for metastasis and inflammation. Key Benefits Selective for only one allosteric site on CXCR4. Lower adverse effects. Market Summary Activation of the CXCR4 receptor triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone...

Published: 7/30/2024 | Inventor(s): Hyunsuk Shim, Yoon Hyeun Oum

Keywords(s): Immunology/Inflammation, Oncology, Small Molecule

Category(s): TechPub Algolia > Therapeutics

Glycoprotein Tetramer for Identifying Antigen-specific B Cells

Application Ectodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells. Key Benefits Viral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues. Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus. Market Summary Hepatitis...

Published: 10/28/2024 | Inventor(s): Arash Grakoui, Joseph Marcotrigiano

Keywords(s): Antibody, Enzyme/Protein, Immunology/Inflammation

Category(s): TechPub Algolia > Vaccines, TechPub Algolia > Diagnostics

Therapeutic Target for Hepatic Fibrosis

ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, injury....

Published: 11/20/2024 | Inventor(s): Frank Anania, Pradeep Kumar

Keywords(s): Enzyme/Protein, Hepatology, Immunology/Inflammation, Target

Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery

CIITA Deficient Human B Cell Line

Application Human B cell line deficient in class II transactivator (CIITA). Key Benefits Deficient in CIITA. Useful for expression of tranfected MHC-II genes and alleles. Technical Summary The class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes. However, the role of CIITA...

Published: 9/26/2024 | Inventor(s): Jeremy Boss, Christopher (Chris) Scharer

Keywords(s): Cell Line, Immunology/Inflammation

Category(s): TechPub Algolia > Research Tools

Transgenic Mice for Studying Cell-Type Specific Immunity

ApplicationTransgenic mice expressing floxed mitochondrial antiviral-signaling protein (MAVS) for study of cell-type and tissue-specific immunity.Key BenefitsStudy cell-type and tissue-specific immunity.Can be crossed using CRE-recombinase system.Technical SummaryMitochondrial antiviral-signaling protein (MAVS) is a protein in humans that is encoded...

Published: 11/20/2024 | Inventor(s): Mehul Suthar

Keywords(s): Animal Model, Immunology/Inflammation, Microbiology/Infectious Diseases

Category(s): TechPub Algolia > Research Tools

Recombinant Respiratory Syncytial Virus (RSV) Firefly Luciferase Reporter Strain

Application Modified recombinant syncytial virus (RSV) strain expressing a bioluminescent reporter protein for high throughput screening and vaccine development. Key Benefits Provides a new high throughput screening tool for RSV vaccine development and drug discovery. Firefly luciferase based assays show better signal-to-noise than fluorescence-based...

Published: 9/26/2024 | Inventor(s): Richard Plemper, Martin Moore

Keywords(s): Immunology/Inflammation, Microbiology/Infectious Diseases, Respiratory

Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Vaccines

Recombinant RSV Strains Expressing Renilla Luciferase and G & F Proteins

Application Recombinant respiratory syncytial virus (RSV) strains expressing the G and F Proteins from RSV strains as well as renilla luciferase for use in drug and vaccine screening. Key Benefits Provides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, distinct strains of the virus....

Published: 9/26/2024 | Inventor(s): Martin Moore, Jia Meng

Keywords(s): Immunology/Inflammation, Microbiology/Infectious Diseases, Respiratory

Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Vaccines

Human Small Airway Cell Culture System for Drug Screening and Research of Airway Diseases and Conditions

Application Cell culture system that acts as an in vitro model for infection and stress-induced airway inflammation; used for research and drug discovery/screening. Key Benefits Improved structure of system offers natural path for neutrophil transepithelial migration, unlike current systems. More accurately models pathological environment due...

Published: 9/26/2024 | Inventor(s): Rabindra Tirouvanziam

Keywords(s): COVID19, Immunology/Inflammation, Respiratory

Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Drug Discovery

Respiratory Syncytial Virus (RSV) A/2001/2-20 Strain with Enhanced Pathogenesis

Applications Strain of respiratory syncytial virus (RSV) for use in drug and vaccine development. Key Benefits Exhibits increased mucin expression and early epithelial damage in mouse models. Provides a platform for animal models focused on early airway histopathology. Market Summary RSV is the most common cause of severe respiratory illness...

Published: 9/26/2024 | Inventor(s): Martin Moore

Keywords(s): Immunology/Inflammation, Microbiology/Infectious Diseases, Respiratory

Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Vaccines

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