Search Results - immunology%2finflammation

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MVA and DNA Based SARS-CoV-2 Vaccines
Application Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Safety profile is known. Demonstrated antiviral activity against related Coronaviruses. Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 7/30/2024   |   Inventor(s): Rama Rao Amara, Sailaja Gangadhara
Keywords(s): Biologic, COVID19, Immunology/Inflammation, Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Vaccines
Vaccine-pulsed Dendritic Cells as a Treatment for Aggressive Breast Cancers
Application Immunotherapy for HER2+ and triple-negative breast cancer. Key Benefits Autologous vaccine comprising patient-specific tumor antigens and immune stimulatory components against aggressive breast cancers. Prepared outside of the body and then administered to patients. Preclinical data indicate treatment decreases tumor growth and improves...
Published: 8/22/2024   |   Inventor(s): Periasamy (Selva) Selvaraj, Luis Munoz, Ramireddy Bommireddy, Christopher Pack, Shaker Reddy, Sampath Ramachandiran
Keywords(s): Immunology/Inflammation, Oncology, Women's Health
Category(s): TechPub Algolia > Therapeutics
Method for Identifying and Optimizing the Development of Heterodimeric Monoclonal Antibodies
Application Method to generate IgG heterodimers that can be used to generate bi-specific monoclonal antibodies for disease treatment. Key Benefits A novel method of screening and developing novel IgG heterodimers used for generating monoclonal antibodies for many diseases. Preliminary data demonstrate efficient production of IgG heterodimers that...
Published: 8/22/2024   |   Inventor(s): Eric Sundberg, Jonathan Du, Tala Azzam
Keywords(s): Antibody, Immunology/Inflammation, Metabolic Diseases, Microbiology/Infectious Diseases, Oncology
Category(s): TechPub Algolia > Therapeutics
Engineering Asymmetrically Glycosylated IgG Antibodies
Application A novel method to develop asymmetrically glycosylated therapeutic monoclonal IgG antibodies for preventing and treating diseases like cancer, infectious diseases, and autoimmune disorders. Key Benefits Different IgG antibody glycoforms can be produced, each with its unique effector functions and biological and therapeutic effects. Potential...
Published: 7/30/2024   |   Inventor(s): Eric Sundberg, Jonathan Du, Tala Azzam
Keywords(s): Antibody, Immunology/Inflammation, Microbiology/Infectious Diseases, Oncology
Category(s): TechPub Algolia > Therapeutics
Novel Endoglycosidase Derivatives Treating Diseases of the Adaptive Immune System
Application Protein-based therapeutics for the treatment of IgG-mediated diseases. Key Benefits A new class of endoglycosidases for the treatment of IgG-mediated diseases. Four novel compounds have been developed that exhibited robust in vitro activity. Potential to become first-in-class medications for dysregulation of the adaptive immune system,...
Published: 8/22/2024   |   Inventor(s): Eric Sundberg, Diego Sastre, Jonathan Du, Jeffrey Ravetch, Stylianos Bournazos
Keywords(s): Enzyme/Protein, Immunology/Inflammation, Metabolic Diseases, Oncology
Category(s): TechPub Algolia > Therapeutics
Vital Sign Trajectory Algorithm
Application A precision medicine algorithm that reduces mortality in sepsis patients by individualizing and targeting specific therapies to specific patients. Key Benefits An algorithm that uses bedside routine vital signs to optimize the precision treatment of sepsis. Clinical data show the ability of the algorithm to identify a subset of patients...
Published: 7/30/2024   |   Inventor(s): Sivasubramanium (Siva) Bhavani
Keywords(s): Hospital and Surgery, Immunology/Inflammation
Category(s): TechPub Algolia > Software
Total Ankle Arthroplasty Design
Application An intra-articular alignment guide for ankle replacement system to treat ankle arthritis. Key Benefits Less invasive method that does not require drilling a hole through the heel for Inbone II tibial stem placement. More convenient to use compared to Inbone II frame and foot holder to find the correct alignment. Market Summary Approximately...
Published: 7/30/2024   |   Inventor(s): Rishin Kadakia
Keywords(s): Hospital and Surgery, Immunology/Inflammation
Category(s): TechPub Algolia > Medical Device
Improving Pediatric Asthma Management for Urban Families
Application Home-based family psychoeducational intervention for low-income children with persistent asthma. Key Benefits Medical and psychosocial needs of patients and family members can be addressed simultaneously. Significantly improved asthma management and caregiver stress in randomized controlled clinical trial. Market Summary Asthma...
Published: 7/30/2024   |   Inventor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
Keywords(s): Education & Training, Immunology/Inflammation, Respiratory
Category(s): TechPub Algolia > Therapeutics
Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage. Key Benefits Currently there is no method to determine if an MSC donor line will be therapeutically effective. Provides a point of use assay in the clinical setting which can determine MSC efficacy...
Published: 7/30/2024   |   Inventor(s): Nick Willett, Levi Wood, Jay McKinney
Keywords(s): Cell/Gene Therapy, Immunology/Inflammation
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
Novel Piperidine-Amide Derivatives as CXCR4 Modulators
­ Application A new class of CXCR4 modulators for metastasis and inflammation. Key Benefits Selective for only one allosteric site on CXCR4. Lower adverse effects. Market Summary Activation of the CXCR4 receptor triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone...
Published: 7/30/2024   |   Inventor(s): Hyunsuk Shim, Yoon Hyeun Oum
Keywords(s): Immunology/Inflammation, Oncology, Small Molecule
Category(s): TechPub Algolia > Therapeutics
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