Search Results - masaki+terabe

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Multi-epitope Vaccines against TARP (ME-TARP) for Treating Prostate and Breast Cancer
Abstract: The development of more targeted means of treating cancer is vital. One option for a targeted treatment is the creation of a vaccine that induces an immune response only against cancer cells. In this sense, vaccination involves the introduction of a peptide into a patient that causes the formation of antibodies or T cells that recognize the...
Published: 4/22/2025   |   Inventor(s): Lauren Wood, Jay Berzofsky, Brenda Roberson, Masaki Terabe
Keywords(s): BREAST CANCER, CANCER VACCINE, Immunotherapy, PROSTATE CANCER
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines
3-o-sulfo-galactosylceramide Analogs for Targeting Lung Metastases
Summary: Lung metastases represent a major clinical challenge in advanced cancer, with poor survival rates and no effective therapies to prevent their development. Researchers at the National Cancer Institute (NCI) have developed C24:2, a first-in-class synthetic 3-O-sulfo-galactosylceramide analog. After lysosomal processing by dendritic cells, C24:2...
Published: 9/15/2025   |   Inventor(s): Lise Pasquet, Jay Berzofsky, Amy Howell, Masaki Terabe, Kaddy Camara
Keywords(s): 3-o-sulfo-galactosylceramide Analogs, Berzofsky, C24:2, Immunotherapy, lung cancer, Metastasis, Natural Killer cells, NKT cells, Sulfatide Analogs, T Cells
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology
Cancer Vaccines against POTE for Treating Solid Tumors
Abstract: POTE is a novel tumor antigen expressed in a variety of cancers including breast, prostate, colon, lung, ovary, and pancreas cancers.  POTE has limited expression in normal tissues and therefore a specific target for cancer treatments, including immunotherapy.  The researchers seek statements of capability or interest from parties interested...
Published: 4/22/2025   |   Inventor(s): Jay Berzofsky, Yi-Hisang Huang, Masaki Terabe, Ira Pastan
Keywords(s): CANCER, immunogenic peptides, Immunotherapy, POTE, Vaccine
Category(s): Application > Vaccines, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Cancer Therapeutic based on Stimulation of Natural Killer T-cell Anti-tumor Activity
Abstract: Natural killer T cells (NKT) are a unique lymphocyte population that has T-cell and NK cell functional properties in order to rapidly elicit an immune response.  alpha-galactosylceramide (alpha-GalCer) is a potent NKT stimulator and induces of IFN-gamma release to promote immunity against tumors and infectious agents.  Humans have natural...
Published: 4/22/2025   |   Inventor(s): Masaki Terabe, Jessica O'Konek, Petr Illarionov, Jay Berzofsky, Gurdyal Besra
Keywords(s): ANTIBODY, Immunity, NKT activity
Category(s): Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Collaboration Sought > Licensing