Search Results - guozhen+liu

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Transgenic Mouse Model for Marfan Syndrome Research

Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...

Published: 12/23/2025 | Updated: 12/23/2025 | Inventor(s): Li Li, Shichao Wu, Jiawei Zhao

Keywords(s):

Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic

DNA Methylation Barriers

In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Published: 2/26/2026 | Updated: 4/5/2024 | Inventor(s): Li Liu, Jingmin Shu

Keywords(s):

Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices

Amphiphilic macromolecules with novel hydrophobic segments

Invention Summary: Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...

Published: 2/20/2026 | Updated: 3/17/2022 | Inventor(s): Kathryn Uhrich, Allison Faig, Dalia Abdelhamid, Li Gu

Keywords(s): Antibacterial, Biomaterials, Polymers & Composites

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 1/9/2026 | Updated: 1/13/2022 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

A Method to Prepare Dead Tumor Cells and Use Thereof (UCLA Case No. 2020-179)

SUMMARYUCLA researchers in the Department of Bioengineering have developed a novel method to generate dead tumors cells for use in cancer therapeutics.BACKGROUNDCancer is a deadly disease that causes approximately 10 million yearly deaths across the globe. While solid tumors may often be fully resected by surgery, the treatment of hematologic malignancies...

Published: 7/17/2025 | Updated: 6/24/2021 | Inventor(s): Zhen Gu

Keywords(s): Medical Devices and Materials, Oncology, Therapeutics & Vaccines

Category(s): Therapeutics > Oncology

Injectable Biodegradable Polymeric Complex for Glucose-Responsive Insulin Delivery (UCLA Case No. 2021-116)

Summary: UCLA researchers in the department of Bioengineering have developed a biodegradable material that is capable of releasing insulin in the presence of excess glucose mimicking the insulin secretion properties of pancreatic B-cells as a treatment for Diabetes Mellitus.Background: Diabetes mellitus currently affects more than 463 million people...

Published: 2/14/2025 | Updated: 6/17/2021 | Inventor(s): Zhen Gu

Keywords(s):

Category(s): Platforms > Drug Delivery > Other Polymers, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Metabolism And Endocrinology

Knowledge Discovery from Citation Networks

A Bernoulli Process Topic (BPT) model that enables knowledge discovery from citation networks to improve data mining tasks Background: Knowledge discovery from citation networks (i.e., textual data with links such as scientific articles, legal documents, webpages, and emails) provides insight into vast areas since huge repositories are made available...

Published: 11/12/2025 | Updated: 1/28/2020 | Inventor(s): Zhongfei Zhang, Zhen Guo

Keywords(s): #SUNYresearch, Technologies

Category(s): Technology Classifications > Computers, Campus > Binghamton University

Semi-supervised Learning Based on Semiparametric Regularization

Semiparametric regularization based approach allows a family of algorithms to be developed based on various choices of the original RKHS and the loss function Technology Overview: Labeled data are often expensive to obtain since they require the efforts of experienced experts. Meanwhile, the unlabeled data are relatively easy to collect. Semiparametric...

Published: 11/12/2025 | Updated: 1/27/2020 | Inventor(s): Zhongfei Zhang, Guo Zhen

Keywords(s): #SUNYresearch, Technologies

Category(s): Technology Classifications > Computers, Technology Classifications > Information Technology, Campus > Binghamton University

Enhanced Max Margin Learning on Multimodal Data Mining in a Multimedia Database

This technology introduces a faster and more scalable machine learning framework for analyzing and retrieving multimodal data such as images and text. It enables real-time querying and pattern discovery even in very large databases while maintaining high accuracy in complex data environments. The approach significantly improves efficiency for large-scale...

Published: 4/24/2026 | Updated: 1/27/2020 | Inventor(s): Zhen Guo, Zhongfei Zhang

Keywords(s): #SUNYresearch, Technologies

Category(s): Technology Classifications > Computers, Campus > Binghamton University

ELISA-On-A-Stick: in vivo detection and measurement of biological materials

Market NeedIn order to understand the role of the molecular signalling events of the immune system it is essential to monitor the concentration of localized pro-inflammatory cytokines in key anatomical compartments repeatedly over time.Cytokines are the small proteins secreted from cells. They are indicators of the functional status of the human immune...

Published: 10/29/2018 | Updated: 5/30/2018 | Inventor(s): Ewa Goldys, Guozhen Liu, Mark Hutchinson

Keywords(s):

Category(s): Medical, Devices, Diagnostic, Drug Delivery, Nanotechnology, Optics, Biology, Biotechnology, Therapeutic

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