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Search Results - guozhen+liu
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Method of Treating Obesity-Induced Glucose Intolerance and Liver Fibrosis (UCLA Case No. 2021-323)
UCLA researchers in the School of Engineering have discovered a novel method to treat obesity-induced glucose intolerance and liver fibrosis. BACKGROUND: The CDC reports that 41.9% of adults ages 20 and over are obese. An increased incidence of obesity also increases the rates of comorbidities such at type 2 diabetes mellitus (T2DM), non-alcoholic...
Published: 9/24/2024
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Inventor(s):
Zhen Gu
Keywords(s):
glucose intolerance
,
liver fibrosis
,
Nanoparticles
,
Notch signaling pathway
,
obesity
Category(s):
Therapeutics > Metabolism And Endocrinology
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 6/5/2024
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Inventor(s):
Li Liu
,
Jingmin Shu
Keywords(s):
Category(s):
Applied Technologies
,
Genomic Assays/Reagents/Tools
,
Life Science (All LS Techs)
,
Diagnostic Assays/Devices
Amphiphilic macromolecules with novel hydrophobic segments
Invention Summary: Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...
Published: 4/17/2024
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Inventor(s):
Kathryn Uhrich
,
Allison Faig
,
Dalia Abdelhamid
,
Li Gu
Keywords(s):
Antibacterial
,
Biomaterials
,
Polymers & Composites
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024
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Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
JobViz: User Interface for Visualization of Majors & Jobs
Invention Summary: University (and industry) career search portals and web-based job search engines allow users to search on many items (e.g., education, location, level, etc.) and then present a text based list of potential job opportunities. University career portals are not as conductive to exploration by job and career searchers as they could...
Published: 9/8/2022
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Inventor(s):
Deborah Silver
,
Li Liu
Keywords(s):
Category(s):
Technology Classifications > Software & Copyright
,
Technology Classifications > Software & Algorithms
2020-179 A METHOD TO PREPARE DEAD TUMOR CELLS AND USE THEREOF
SUMMARYUCLA researchers in the Department of Bioengineering have developed a novel method to generate dead tumors cells for use in cancer therapeutics.BACKGROUNDCancer is a deadly disease that causes approximately 10 million yearly deaths across the globe. While solid tumors may often be fully resected by surgery, the treatment of hematologic malignancies...
Published: 9/5/2023
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Inventor(s):
Zhen Gu
Keywords(s):
Medical Devices and Materials
,
Oncology
,
Therapeutics & Vaccines
Category(s):
Therapeutics > Oncology
Injectable Biodegradable Polymeric Complex for Glucose-Responsive Insulin Delivery (UCLA Case No. 2021-116)
Summary: UCLA researchers in the department of Bioengineering have developed a biodegradable material that is capable of releasing insulin in the presence of excess glucose mimicking the insulin secretion properties of pancreatic B-cells as a treatment for Diabetes Mellitus.Background: Diabetes mellitus currently affects more than 463 million people...
Published: 8/9/2024
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Inventor(s):
Zhen Gu
Keywords(s):
Category(s):
Platforms > Drug Delivery > Other Polymers
,
Therapeutics > Inflammation And Inflammatory Diseases
,
Therapeutics > Metabolism And Endocrinology
2020-854 DUAL SELF-REGULATED DELIVERY OF INSULIN AND GLUCAGON BY A HYBRID PATCH
UCLA researchers have developed a novel hybrid microneedle patch that can deliver insulin and glucagon in a glucose-dependent manner. BACKGROUND: Type I diabetes (T1D) is an autoimmune disease in which pancreatic -cells are destroyed and there is a deficiency is insulin secretion. Type 2 diabetes (T2D) is a metabolic disorder resulting from insulin...
Published: 7/19/2023
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Inventor(s):
Zhen Gu
Keywords(s):
Drug Delivery
,
Medical Devices and Materials
,
Metabolic Diseases
,
Other Polymers
,
Polymers
,
Therapeutics & Vaccines
Category(s):
Medical Devices
,
Platforms > Drug Delivery
,
Therapeutics
,
Platforms > Drug Delivery > Other Polymers
,
Therapeutics > Metabolism And Endocrinology
2020-178 COLD ATMOSPHERIC PLASMA TREATMENT FOR CANCER IMMUNOTHERAPY
UCLA researchers in the Department of Bioengineering have developed a novel cancer treatment using a combination of microneedle patch-assisted cold atmospheric plasma and checkpoint blockade.BACKGROUND: Immunotherapy revolutionizes cancer treatment by harnessing the power of the immune system for fighting cancer. Among all immunotherapeutic strategies,...
Published: 7/19/2023
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Inventor(s):
Zhen Gu
,
Richard Wirz
,
Guojun Chen
,
Zhitong Chen
Keywords(s):
Medical Devices and Materials
,
Oncology
,
Oncology Immunotherapy
,
Therapeutics & Vaccines
Category(s):
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology Immunotherapy
Knowledge Discovery from Citation Networks
A Bernoulli Process Topic (BPT) model that enables knowledge discovery from citation networks to improve data mining tasks Background: Knowledge discovery from citation networks (i.e., textual data with links such as scientific articles, legal documents, webpages, and emails) provides insight into vast areas since huge repositories are made available...
Published: 4/18/2024
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Inventor(s):
Zhongfei Zhang
,
Zhen Guo
Keywords(s):
#SUNYresearch
,
Technologies
Category(s):
Technology Classifications > Computers
,
Campus > Binghamton University
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