Search Results - fengqing+zhang

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Advanced hot melt extrusion (HME) technology with reduced decomposition
The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability. Background HME is a widely used technique in the pharmaceutical...
Published: 9/10/2024   |   Inventor(s): Feng Zhang, Robert Williams, Abbe Miller, Siyuan Huang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery, Life sciences > Biomaterials
Inhaled formulations of the NSAID indomethacin
Background Patients suffering from headache and migraine have a limited list of thera­peutic options that often is shortened by issues stemming from tolerability or efficacy. For this reason, there is a big push in the industry to develop inhaled treatments for these disorders. The invention described here repurposes a compound with known efficacy...
Published: 5/8/2024   |   Inventor(s): Hugh Smyth, Feng Zhang, Jamie Spahn
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Manufacturing platform
COMBINATION THERAPIES FOR COVID-19 (SARS-COV-2)
The coronavirus disease 2019 (COVID-19) is caused by a novel RNA enveloped coronavirus, SARS-CoV-2 when the virus enters human airway cells via an ACE2-mediated entry process. This entry pathway is facilitated by the cell surface heparan sulfate proteoglycan (HSPG), which enhances viral attachment to the cell surface. Researchers at NIDDK and NCATS...
Published: 7/25/2024   |   Inventor(s): Qi Zhang, Wei Zheng, Catherine Chen, Yihong Ye
Keywords(s): COVID-19, DB4BXX, ENTRY, HEPARAN, option, Sulfate-dependent, Targeting, therapeutic, viral
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics
A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells
Heparan sulfate proteoglycan (HSPG) is a group of lipid-anchored proteoglycans, engaged in a variety of key biological functions on cell surface. HSPG-mediated endocytosis of neurotoxic protein aggregates has been linked to aging related neurodegenerative diseases. Labeling HSPG is a promising technique to trace cell profile in cell research, monitor...
Published: 7/25/2024   |   Inventor(s): Qi Zhang, Yihong Ye
Keywords(s): Cells, HEPARAN, Label, MAMMALIAN, MEMBRANE, Method, PLASMA, PROTEOGLYCAN, R1XXXX, SULFATE, XCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023   |   Inventor(s): Leilei Peng, Yu Li, Han Zhang
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
A Mutually Inhibitory Network with Positive Autoregulation and Communications (MINPAC)
Biological pattern formation requires complex gene regulation networks and accurate cell-cell coordination. The reaction-diffusion (RD) based clock and wavefront model has been proposed as a mechanism involved in biological pattern formation of repeated and segmented structures. While RD driven pattern formation has been demonstrated in many systems,...
Published: 2/23/2023   |   Inventor(s): Fuqing Wu, Samat Bayakhmetov, Changhan He, Qi Zhang, Xingwen Chen, Yang Kuang, Xiao Wang
Keywords(s):  
Category(s): Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Computing & Information Technology
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 2/23/2023   |   Inventor(s): Qi Zhang, Xiao Wang, Alexander Green, Duo Ma, Fuqing Wu, Kylie Standage-Beier, Xingwen Chen
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Model for Gene Expression Tuning and Synthetic Gene Circuit Construction
Genetic circuit engineering has played an important role in many forms of synthetic biology. Based on a large collection of well characterized biological components, complex gene circuits with designed functions can be wired using established biological principles. Currently circuit assembly has two main strategies: one is monocistronic construct, in...
Published: 2/23/2023   |   Inventor(s): Fuqing Wu, Xiao Wang, Qi Zhang
Keywords(s):  
Category(s): Computing & Information Technology, Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Life Science (All LS Techs)
Cellulose Dispersions for Reducing Cold Damage in Tree Fruit
Unmet Need: More cost-effective and less labor-intensive cold damage protection technologyEconomic loss from cold damage is one of the most prevalent recurring production issues in temperate fruit industry, and poses a significant challenge to profitable and sustainable production. Each year, the U.S. produces >15M tons of deciduous fruit crops that...
Published: 8/3/2023   |   Inventor(s): Xiao Zhang, Changki Mo, Matthew Whiting, Qin Zhang
Keywords(s):  
Category(s): Technologies > Food & Nutrition > Agriculture and Plant Sciences, Technologies > Energy & Environment > Clean Tech, Technologies > Health & Well-being > Chemistry
Electroencephalogram-Based Estimation of Brain Age
PAGE TITLEFunctional Brain Age Estimation Via Resting State EEG PAGE SUMMARYThe early detection and quantification of abnormal brain changes are important for the prospective identification and subsequent treatment of individuals at risk for various neurological disorders, injuries, and cognitive decline. Discrepancies between an individual’s...
Published: 8/5/2021   |   Inventor(s): John Kounios, Fengqing Zhang, Jessica Fleck
Keywords(s):  
Category(s): Research Tools & Materials, Medical Devices & Diagnostics, Digital Health & Healthcare IT, Medical Devices & Diagnostics > MDD: Imaging, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Digital Health & Healthcare IT > Dig. Health: Imaging, Digital Health & Healthcare IT > Dig. Health: Psychology
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