Search Results - eugene+major

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Use of Antisense Oligodeoxynucleotides for Inhibiting JC Virus
Progressive multifocal leukoencephalopathy (PML) is a rare, fatal demyelinating disease of the brain caused by the polyomavirus JC (JCV) under immunosuppressive conditions. It is pathologically characterized by progressive damage of white matter of the brain by destroying oligodendrocytes at multiple locations. Clinically, PML symptoms include weakness...
Published: 10/28/2024   |   Inventor(s): Avindra Nath, Eugene Major, Maria Monaco-Kushner, Michael Ferenczy, Laura Jaeger
Keywords(s): Anti-JC, Antisense, Cocktail, DAXXXX, DB4BXX, DB4XXX, DB5XXX, DBXXXX, DD1XXX, DDXXXX, DXXXXX, virus, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Infectious Disease
Methods and Composition for Identification of Variants of JC Virus DNA; An Etiologic Agent for Progressive Multifocal Leukoencephalopathy (PML)
JC Virus causes a fatal disease in the brain called progressive multifocal leukoencephalopathy (PML) that occurs in many patients with immunocompromised conditions. The finding of JCV DNA in the patients with neurological symptoms of PML is a diagnostic criterion and is needed to confirm the diagnosis of PML to rule out other neurological conditions....
Published: 10/28/2024   |   Inventor(s): Caroline Ryschkewitsch, Eugene Major
Keywords(s): Chain, DA4BXX, DA4XXX, DAXXXX, DD1XXX, DDXXXX, DETECTS, DEXXXX, Distinguishes, DNA, DXXXXX, GENOTYPES, Multiplex, NON-PATHOGENIC, PATHOGENIC, polymerase, PRESENCE, REACTION, That, viral
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease
qPCR Assay for Detection of JC Virus
JC Virus causes a fatal disease in the brain called progressive multifocal leukoencephalopathy (PML) that occurs in many patients with immunocompromised conditions. For example, more than five percent (5%) of AIDS patients develop PML. Additionally, these conditions include, but are not limited to, cancers such as leukemias and lymphomas, organ transplants...
Published: 10/28/2024   |   Inventor(s): Caroline Ryschkewitsch, Eugene Major
Keywords(s): assay, DA4BXX, DA4XXX, DAXXXX, DDXXXX, Detection, DEXXXX, DNA, DXXXXX, JC, Proficiency, Progressive multifocal leukoencephalopathy, QPCR, Samples', STANDARDS, Systemic lupus erythematosus, test, virus
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease
Recombinant Baculoviruses Containing Inserts of the Major Structural Genes (vp1) of the Human Polyomaviruses JCV and BKV
The development of sensitive and specific tests for JC virus and BK virus activity may provide tools essential in the steps required to find a treatment for these fatal infections. This invention describes a Recombinant Vpl protein (rVp1) that can be used 1) as an antigen source for ELISA assays 2) for studies of viral proteins in cells and 3) for...
Published: 10/28/2024   |   Inventor(s): Peter Jensen, Eugene Major
Keywords(s): Baculovirus, BKV, Containing, DA4BXX, DA4XXX, DAXXXX, DDXXXX, DXXXXX, GENES, Human, Inserts, JCV, MAJOR, Polyomavirus Infections, Polyomaviruses, recombinant, STRUCTURAL, VP1
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials
Antibodies that Selectively Detect the Human Nestin Protein
Nestin is an intermediate filament protein first described in early embryonic neuroepithelial stem cells. Although not found in most cells of the mature CNS, nestin is the predominant marker used to detect the small population of undifferentiated cells. The presence of nestin identifies stem, progenitor and some tumor cells in the CNS, and also labels...
Published: 10/28/2024   |   Inventor(s): Conrad Messam, Eugene Major, Jean Hou
Keywords(s): Antisera, Cross, Human, Listed LPM Maddox as of 4/15/2015, Nestin, polyclonal, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R1XXXX, rabbit, Reactive, Rodent, RXXXXX, Specific, X
Category(s): Collaboration Sought > Licensing, Application > Research Materials