Search Results - antisense

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Antisense Oligonucleotides against Cancer Cell Migration and Invasion
Abstract: Advanced stage cancers are typically marked by metastases of the primary cancer to secondary sites such as lungs, liver, and bones. Such metastatic cancers result in strikingly low 5-year survival rates, underscoring the need for novel therapeutics. For example, bone metastasis of primary breast cancer has a 5-year survival rate of 13%, lung...
Published: 4/8/2024   |   Inventor(s): Stavroula Mili
Keywords(s): Antisense, APC, CANCER, Invasion, Metastasis, MIGRATION, Mili, Net1, OLIGO, oligonucleotide, Oncology, Rab13, RNA
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
Use of Antisense Oligodeoxynucleotides for Inhibiting JC Virus
Progressive multifocal leukoencephalopathy (PML) is a rare, fatal demyelinating disease of the brain caused by the polyomavirus JC (JCV) under immunosuppressive conditions. It is pathologically characterized by progressive damage of white matter of the brain by destroying oligodendrocytes at multiple locations. Clinically, PML symptoms include weakness...
Published: 7/25/2024   |   Inventor(s): Avindra Nath, Eugene Major, Maria Monaco-Kushner, Michael Ferenczy, Laura Jaeger
Keywords(s): Anti-JC, Antisense, Cocktail, DAXXXX, DB4BXX, DB4XXX, DB5XXX, DBXXXX, DD1XXX, DDXXXX, DXXXXX, virus, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Infectious Disease
Antisense Agents for Treating SARS-CoV-2 Infection
Background In December 2019, cases of an acute respiratory disease were reported from Wuhan, the capital of Hubei province in China. The number of infections increased rapidly and spread to other areas of China and on January 13th, 2020, the first case was reported outside of China. The causative agent was identified as a novel coronavirus (CoV)...
Published: 7/31/2023   |   Inventor(s): David Stein, Hong Moulton, Kyle Rosenke, Heinrich Feldmann
Keywords(s): antisense, coronavirus, covid-19, Drug, SARS-CoV-2, Therapeutic
Category(s): Therapeutics