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Summary: The NCI seeks research co-development partners or licensees for monoclonal antibodies that specifically target cancer-expressed EGFR. Description of Technology: Epidermal growth factor receptor (EGFR) is a well-known oncogenic driver in lung cancer, head and neck cancer, glioblastoma multiforme (GBM) and other cancers. NCI inventors have...

Published: 2/5/2026 | Inventor(s): David Fitzgerald, Antonella Antignani, Robert Sarnovsky

Keywords(s):

Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration

Supercharged fluorescent protein biosensors for real-time lanthanide monitoring

Background Rare earth elements—particularly lanthanides like terbium, thulium, and dysprosium—are essential to technologies underpinning renewable energy, electrified transportation, high-performance magnets, and medical imaging. As demand accelerates, sustainable extraction and recycling processes require precise monitoring of these valuable...

Published: 1/30/2026 | Inventor(s): Andrew Ellington, Kevin Huang, David Walker

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform, Physical sciences > Environmental & sustainable solutions

Reagent Molding Process for Point of Care Microfluidic Applications

Invention Description Lyophilization is a critical process for stabilizing reagents in point-of-care (POC) diagnostics, effectively eliminating the need for cold chain storage and preventing liquid evaporation. While this technology is essential for developing robust field-deployable devices, current industry standards are limited to producing reagents...

Published: 1/26/2026 | Inventor(s): Jennifer Blain Christen, Vi Nguyen

Keywords(s):

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Point of Care

Pharmacological strategy to treat hydrocephalus

This technology offers a non-surgical treatment for hydrocephalus by using drugs to enhance the removal of harmful macromolecules from the brain’s ventricles, targeting specific cellular transport mechanisms to reduce fluid buildup and disease progression. Background: Hydrocephalus is a neurological disorder characterized by the abnormal accumulation...

Published: 1/29/2026 | Inventor(s): Satish Krishnamurthy, David Lehmann

Keywords(s): hydrocephalus, pharmacology, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare

A Method for One-Step, Aqueous Phase Generation of Ultrasmall Inorganic Nanoparticles for Biomedical Applications.

A method to generate homogenous and stable inorganic nanoparticles (NPs) using a microfluidic device with two jet inlets. Problem: Inorganic nanoparticles have promise as contrast agents and therapeutics due to their high renal clearance and therefore low toxicity. However, they are limited by factors including complex synthesis routes with unfavorable...

Published: 1/21/2026 | Inventor(s): David Cormode, Hyun (Michel) Koo, Nil Kanatha Pandey, Andrea Kian, Portia Maidment, Derick Rosario Berrios

Keywords(s): Microfluidics, Platform Technology, Radiology

Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents

User-Actuated Valve Actuator for Microfluidic Devices

Invention Description Lab-on-a-chip technology and microfluidic diagnostic devices often rely on complex mechanical or electrical systems to manipulate fluid, making them costly and bulky. These components may limit portability, decrease operational lifetime, and prevent widespread use by untrained personnel or patients at the point of care or at home....

Published: 1/12/2026 | Inventor(s): Clifford Anderson, Vi Nguyen, Jennifer Blain Christen

Keywords(s): Analytical Devices, Bioassay, Biosensor, Fluid, Micro-Fluidics

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Point of Care

Isolation and Separation of Angiotensin I and II from Human Serum Using a New Chromatographic Matrix that Excludes High Molecular Weight Proteins

This innovation introduces a novel chromatographic matrix that effectively isolates and separates angiotensin I and II, key biomarkers involved in blood pressure regulation, from human serum. The system uses a hybrid combination matrix that selectively removes small molecular weight polypeptides while excluding large serum proteins. By integrating chelating...

Published: 1/6/2026 | Inventor(s): Roberto Guzman, David Mier-Salazar, Daniel Alejandro Diaz

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease, Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Medical Devices > Diagnostic

Analytical Technology for the Isolation of 3-Nitrotyrosine as a Biomarker from Urine to Assess Depression and Acute Kidney Injury

This invention uses a novel separation technique to isolate specific biomarkers from urine, as a measure to detect and monitor depression and acute kidney injury (AKI). The system employs a hybrid chromatographic matrix that rejects biomolecules of specific sizes and allows only the desired small compounds, such as 3-nitrotyrosine (which has been linked...

Published: 1/6/2026 | Inventor(s): Roberto Guzman, David Mier-Salazar

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Nephrology/Renal, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Medical Devices > Diagnostic

Integrated Microfluid Cartridge for POC Biofluid Diagnostics

Invention Description Rapid and reliable nucleic acid assays are critical for diagnosing infectious diseases at the point of need, yet most systems rely on complex, expensive instrumentation and trained personnel. These requirements limit access to timely diagnostics in low-resource, remote, or decentralized settings. Many platforms typically require...

Published: 1/6/2026 | Inventor(s): Vi Nguyen, Clifford Anderson, Jennifer Blain Christen

Keywords(s):

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Coronavirus, COVID-19, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Point of Care, SARS-CoV-2

Arty Puzzle: Closed-Curve Innovation in Polyhedral Puzzles

Advantages Educational: Enhances spatial reasoning and understanding of geometric principles. Artistic: Combines mathematical precision with visual creativity for an engaging experience. Recreational: Offers a challenging yet rewarding puzzle-solving activity suitable for all ages, low-cost, and easy to produce via 3D printing Summary Non-Euclidean...

Published: 1/6/2026 | Inventor(s): David Milligan

Keywords(s): Simulation Training Aid, Tests, Questionnaires and Surveys

Category(s): Technology Classifications > Arts and Humanities > Edtech

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