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Mitochondrial Proteins as Predictors of Response to Anti-Cancer Agents (UCLA Case No. 2025-055)
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Published: 9/17/2025   |   Inventor(s): David Shackelford, Aaron Lisberg
Keywords(s):  
Category(s): Therapeutics > Oncology
Enhance Sensitivity of Mutation-Detection by EFIRM with a Saliva Preservative Solution (UCLA Case No. 2023-101)
UCLA researchers led by Prof. David T. Wong of the School of Dentistry have developed a breakthrough in noninvasive cancer diagnostics, combining the Spectrum Saliva Collector (SDNA-1000) with a preservative solution and cutting-edge Electric Field-Induced Release and Measurement (EFIRM) technology for sensitive, rapid detection of EGFR mutations in...
Published: 9/12/2025   |   Inventor(s): David Wong
Keywords(s):  
Category(s): Diagnostic Markers
Stealth Communication System Using Error-Pattern Embedding Case
Wireless networks have seen exponential growth in popularity due to the inherent accessibility provided by the broadcast nature of the wireless medium. However, this ease of reception also introduces significant security vulnerabilities. Within the range of wireless transmissions between transmitters and legitimate receivers, passive eavesdroppers can...
Published: 9/12/2025   |   Inventor(s): Yongkyu Jang, Taejoon Kim, David Love
Keywords(s):  
Category(s): Wireless & Networking, Physical Science, Intelligence & Security, Cybersecurity, Computing & Information Technology
An 18F-Labeled Novel Brain Penetrant EGFR Inhibitor to Facilitate Clinical Development for Glioblastoma (UCLA Case No. 2022-316)
UCLA researchers led by Professors Jennifer Murphy and David Nathanson have developed 18F-labeled brain-penetrant EGFR tyrosine kinase inhibitors (TKIs) as PET tracers specifically designed for imaging glioblastoma (GBM), a highly aggressive brain cancer characterized by aberrant EGFR signaling. The 18F-labeled brain-penetrant EGFR TKI PET tracers represent...
Published: 9/12/2025   |   Inventor(s): Jennifer Murphy, David Nathanson
Keywords(s):  
Category(s): Therapeutics > CNS and Neurology, Medical Devices > Medical Imaging
Co-Deacidification and Dechlorination of Aqueous/Gaseous Streams by Mineral Dissolution (Case No. 2022-173)
Summary UCLA researchers have developed a method and composition for simultaneous deacidification and dechlorination of acidic aqueous solutions (including brines or electrolyte streams enriched in free-chlorine species), using mineral or rock solids containing low-valent metals to neutralize acidity and remove chlorine contaminants. Background Electrolytic...
Published: 9/11/2025   |   Inventor(s): Gaurav Sant, David Jassby, Xin Chen, Dante Simonetti, Steven Bustillos
Keywords(s):  
Category(s): Materials, Materials > Functional Materials, Materials > Membranes, Materials > Nanotechnology, Energy & Environment
Physical Separation of Ultrashort Single-Stranded Cell-Free DNA in Biofluids Using Differential Filtration and Next-Generation Sequencing Pipeline to Detect Methylation Status of Ultrashort Single-Stranded Cell-Free DNA (UCLA 2023-077, 2023-082)
UCLA researchers in the Department of Dentistry have established novel extraction and bioinformatics pipeline of ultrashort single-stranded cell-free DNA for the use in liquid biopsy diagnostics. BACKGROUND: Liquid biopsy is a critical diagnostic tool for various human diseases. The rapid market growth of liquid biopsy is primarily driven by novel...
Published: 9/11/2025   |   Inventor(s): David Wong, Jordan Cheng
Keywords(s): Cancer, cell-free DNA, circulating DNA, Diagnostic Markers & Platforms, DNA methylation, liquid biopsy, next generation sequencing (NGS)
Category(s): Software & Algorithms > Bioinformatics, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies
Analysis of Ultrashort Single-Stranded Cell-Free DNA in Patient Saliva for Disease Detection (UCLA Cases 2022-292, 2022-043)
UCLA researchers have developed a novel next-generation sequencing (NGS) pipeline designed specifically to detect ultrashort single-stranded cell-free DNA (uscfDNA), providing significant advancements in sensitivity, clinical utility, and genomic research applications. Background: Cell-free DNA (cfDNA) fragments circulate in body fluids and have become...
Published: 9/11/2025   |   Inventor(s): David Wong, Jordan Cheng
Keywords(s):  
Category(s): Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies
Ultrasonic Process for Selective Extraction of Lithium and Magnesium From Suitable Geological Precursors and Alkaline Indust (Case No. 2022-135)
Summary UCLA researchers have developed new methods for designing and synthesizing inorganic porous materials and extracting valuable metal ions from natural and waste sources. The first technology uses metal cations as inorganic structure-directing agents to control the formation of zeolite (phillipsite) and silicate hydrate (tobermorite) phases without...
Published: 9/11/2025   |   Inventor(s): Gaurav Sant, Ross Arnold, Mathieu Bauchy, Dante Simonetti, Xin Chen, David Jassby, Lawrence Anovitz, Elena Tajuelo Rodriguez
Keywords(s):  
Category(s): Materials, Materials > Metals, Materials > Functional Materials, Energy & Environment
Ultrasensitive, High-Throughput, Single-Scale Detection of Extracellular Vesicles
An optofluidic platform to detect extracellular vesicles (EVs) at the single-particle level by parallelizing droplet generation and analysis of EVs. Problem: Extracellular vesicles (EVs) are lipid bound nanomaterials carrying various molecular cargo that can be representative of their cells of origin. EVs play a critical role in intercellular communication...
Published: 9/10/2025   |   Inventor(s): David Issadore, Zijian Yang
Keywords(s): Bioengineering, Microfluidics, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Visualizing the Impact of Changes in Microservices
This technology is a Software Architecture Visualization and Analysis Tool (SAVAT) designed to assist developers in understanding the impacts and ripple effects of changes in microservice systems. This SAVAT generates visualizations of microservice interactions in the system from service and domain architectural views, integrating context maps, service...
Published: 9/12/2025   |   Inventor(s): Tomas Cerny, Gabriel Goulis, Adam Rahmani, David Kozak, Tomas Vojnar
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Communications & Networking
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