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Targeted modulation of noncoding BMPR2 sequences increases protein expression for treatment of pulmonary arterial hypertension
Problem: Pulmonary arterial hypertension (PAH) is a severe lung disease characterized by elevated pulmonary arterial pressure that is estimated to affect 5,000-15,000 people in the US. Without proper treatment, the elevated pressure leads to heart failure and eventually death—median survival without treatment is around 2-3 years. Management and...
Published: 6/20/2024   |   Inventor(s): Yoseph Barash, Nicholas Hand, Louis Ghanem, David Lee
Keywords(s): Pulmonary
Category(s): Technology Classifications > Therapeutics
Real-Time RT-PCR Assay for Detection of Noroviruses
A specific and sensitive TaqMan-based real-time (rt) RT-PCR assay has been developed by CDC scientists for detection of noroviruses in clinical and environmental specimens. This assay can be implemented to rapidly detect and distinguish norovirus strains from genogroups I and II, which are responsible for the majority of human infections. Additionally,...
Published: 10/28/2024   |   Inventor(s): Nicole Gregoricus, Preeti Chhabra, Leslie Barclay, Hannah Shirley, David Lee, Jan Vinje
Keywords(s): DA4BXX, DA4XXX, DAXXXX, Detection, DXXXXX, Norovirus, SELECTIVE
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Infectious Disease
SCITO-SEQ: SINGLE CELL COMBINATORIAL INDEXED CYTOMETRY SEQUENCING
SCITO-SEQ: SINGLE CELL COMBINATORIAL INDEXED CYTOMETRY SEQUENCING Researchers at UCSF have developed SCITO-seq, a new workflow for single cell sequencing-based proteomics. The use of DNA to barcode and tag antibodies has created new opportunities to use sequencing to profile the molecular properties of thousands of cells simultaneously. Furthermore,...
Published: 1/19/2024   |   Inventor(s): Chun Ye, Byungjin Hwang, David Lee
Keywords(s): Antibody, Droplet-Based Single Cell Sequencing, dsc-Seq, Microfluidics, Proteomics, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit Endospores
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit EndosporesResearchers at Augusta University have invented skin-friendly compositions and methods for killing, inactivating, or otherwise reducing the bacterial endospores by using an effective amount of the green tea EGCG or its derivatives. EGCG research shows clear application for a hand sanitizer...
Published: 4/21/2023   |   Inventor(s): Stephen Hsu, Lee Lee, Tin-Chun Chu
Keywords(s):  
Category(s): Therapeutics