Search Results - juan+valcarcel

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Novel Targets and Compounds to Treat Bladder Cancer
Alternative splicing modulating antisense oligonucleotides (ASOs) targeting novel identified alternative splicing changes associated with RBM10 mutations in bladder cancer. We are developing lead ASOs to treat bladder, and eventually other, cancers. Technology: Bladder cancer is the 9th most common malignant disease worldwide and 13 most frequent...
Published: 8/6/2025   |   Inventor(s): Juan Valcarcel, Ángel Guerra, Tobias Hoffmann
Keywords(s):  
Category(s): Biotechnology, Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
New, targeted lung cancer treatment with splicing-modifying antisense oligonucleotides
A lead splicing-modifying antisense oligonucleotide (AON) delivered to different mice models of lung cancer effectively reduces tumor growth in vivo. The lead AON could be applicable to the targeted treatment of lung adenocarcinoma, lung squamous cell carcinoma, breast, liver, prostate, colon, cervix and other tumor types displaying enhanced NUMB...
Published: 10/10/2024   |   Inventor(s): Juan Valcarcel, Jordi Hernandez Ribera, Elias Bechara
Keywords(s): Oncology, RNA Modulation Technologies, Spliceosome / Splicing
Category(s): Biotechnology, Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)