Search Results - pharma

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The Y161F Substitution of Hemagglutinin Increases Antigenic Thermostability and Improves Yields of Influenza A Viruses
Background Vaccination has been the most efficient and economical strategy for preventing influenza virus infection and controlling disease spread among hosts. A high yield vaccine seed strain is required for timely vaccine manufacture and is thus a critical component of a successful influenza vaccination program. Unfortunately, it is not uncommon...
Published: 9/6/2024   |   Inventor(s): Xiu-Feng (Henry) Wan, Feng Wen
Keywords(s): Biomedical, Human Health, Pharma, Research, Veterinary Medicine
Category(s): Biotechnology, Biomedical, Pharma, Veterinary Medicine
A Method for Targeting Nanoparticles to Bacterial Biofilm Infections using Bacterial Surface Proteins
Background Biofilm‑related infections are associated with high mortality and morbidity, combined with increased hospital stays and overall treatment costs. Traditional antibiotics play an essential role in controlling biofilms; however, they are becoming less effective due to the emergence of drug‑resistant bacterial strains. The need to treat biofilms...
Published: 9/6/2024   |   Inventor(s): Nicholas Fitzkee, Dhanush Amarasekara
Keywords(s): Human Health, Materials, Medical Devices, Military or Defense, Nanotechnology and Nanoscience
Category(s): Biomedical, Biotechnology, Materials, Medical Devices, Pharma
Increased Expression of Hyperpolarization-activated Cyclic Nucleotidgated Channel 4 (HCN4) in Airway Muscle During Naturally Occuring Asthma-like Disease Directs Pharmacologic Modulation of Funny Current Pathways to Modify Bronchial Tone...
TREM1, HMBGB1 and PGLYRP1 Antagonism: Therapeutics for Severe and Neutrophilic Asthma in Horses and Humans Overview of Technology Therapeutics for severe and neutrophilic asthma in horses and humans Background of Technology HMBGI signaling, TREM1 expression and signaling and PGLYRP1 expression are all increased in the lung biopsies of horses with...
Published: 9/9/2024   |   Inventor(s): Cyprianna Swiderski, Courtney Hunter
Keywords(s): Biomedical, Human Health, Medical Devices, Pharma
Category(s): Pharma, Veterinary Medicine
Synthesis of Optically Active Indoline Derivatives via Ruthenium (II)-Catalyzed Enantioselective C-H Functionalization
Overview of Technology Provides a cost-effective, easy preparation, versatile and distinct reactivity for customization of the 4-formyl indoline derivatives Background This novel technology allows for some customization of the RU(II)-catalyzed method during asymmetric synthesis. Using the 4-formylindoline derivative (compound based on the indole...
Published: 7/26/2024   |   Inventor(s): Xin Cui, Zhong-Yuan Li, Chaminda Lakmal Hetti Handi
Keywords(s):  
Category(s): Advanced Materials, Pharma