Search Results - joshua+scallan

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Mouse Model for Direct Visualization of Endothelial Permeability in Disease States: Cdh5-mScarlet Reporter Mouse
Advantages Reporter mouse reliable labels VE-cadherin, replacing the need for difficult immunostaining protocols enables quicker, live, longitudinal imaging of VE-cadherin remodeling and vascular permeability in vivo Far-red mScarlet emission enables clearer deep-tissue imaging and real time quantification of VE-cadherin turnover and junctional...
Published: 6/4/2025   |   Inventor(s): Joshua Scallan
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
Transgenic Foxc2-tdTomato Overexpressing Mouse Model for Study and Screening of Lymphatic Valve Development
Advantages Tissue specific Foxc2 expression with integrated tdTomato fluorescent reporter enables precise spatiotemporal visualization Enables monitoring of lymphatic valve development 1:1 co-expression of Foxc2 and tdTomato, overcoming expression variability characteristic associated with of IRES-based or viral delivery systems Single-vector...
Published: 5/30/2025   |   Inventor(s): Joshua Scallan
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
BAC Transgenic Prox1CreERT2 Mouse Line: Allows for Deletion of 'Floxed' Genes Specifically in the Lymphatic Vasculature
Advantages Distinct BAC backbone allows for transgene integration on a separate chromosome, avoiding linkage and complex breeding schemes observed in current strains. Demonstrates >90% Cre-mediated excision in Prox1+ lymphatic endothelial cells, outperforming previous models which demonstrate ~60-70%. Restricts recombination to lymphatic vasculature...
Published: 5/29/2025   |   Inventor(s): Joshua Scallan
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models