Search Results - -cancer

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Novel bioassay platform for drug and immunotherapy screenings in a personalized format for highly functional cell expansion

INV-19076 Background Immunological screenings for different infections and cancers can yield essential information for developing effect treatments. The efficiency and accuracy of screenings can be improved by choosing efficient matrices and type of assay. Different 3D matrices have been used for immunological screenings. However, due to limited...

Published: 9/10/2024 | Inventor(s): Giovanni Ugolini, Tania Konry

Keywords(s): Analytical Chemistry, Assays, Detection, Immunological/Autoimmune Disease, Microfluidics

Category(s): -Biomedical Materials, -Chemistry, -Devices, -Equipment, -Cancer

Single-cell Pairing Chip for Personalized Immunotherapeutic Screening

INV-19067 Background Natural Killer cells are a type of white blood cell that physically interact with target cancer cells and determine whether to lyse them. The innate heterogeneity of both cancer and NK cells leads to a variety of interactions between pairs of NK-cancer cells. Therefore, single-cell analysis would help in analyzing these interactions...

Published: 9/10/2024 | Inventor(s): Yantao Fan, Tania Konry

Keywords(s): Biotech, Cancer

Category(s): -Biology, -Devices, -Cancer, Technology Classifications > 1. Life Science, Diagnostics, Chemistry, Technology Classifications > 1. Life Science > Drug Discovery

Exosome Detection in Microfluidic Droplets

INV-17081 Background Extracellular vesicles are secreted by cells and contain essential biological components such as proteins, lipids, and genetic materials. Cells use these vesicles to communicate with other cells. These vesicles could be used to introduce therapeutic agents in cells and detect the diseased condition but, detecting cell-secreted...

Published: 9/10/2024 | Inventor(s): Saheli Sarkar, Tania Konry

Keywords(s):

Category(s): -Cancer, Diagnostics, Technology Classifications > 1. Life Science > Biotechnology

Live Single-Cell Bioassay in Micro-droplets

INV-17085 Background The outcome of many pathological diseases including cancer is determined by types (functional and phenotypical) of immune cells present in the body. The existence of tremendous heterogeneity in these cells influences the time taken for the immune reaction and an individual’s ability to recover from the illness. Hence, assessing...

Published: 9/10/2024 | Inventor(s): Tania Konry, Saheli Sarkar, Pooja Sabhachandani

Keywords(s):

Category(s): -Method, -Cancer, Technology Classifications > 1. Life Science, Diagnostics

Satellite-MALDI of Nucleic Acids

INV-18071 Background DNA and RNA structural analysis provides useful information for drug discovery, disease diagnosis, and clinical research. Currently, used detection techniques include liquid chromatography‑mass spectrometry (LC/MS), antibody-based tests such as ELISA and Ames tests. However, these tests are time-consuming, expensive, less accurate,...

Published: 9/10/2024 | Inventor(s): Roger Giese, Poguang Wang

Keywords(s):

Category(s): -Cancer, Technology Classifications > 1. Life Science, Diagnostics, Technology Classifications > 1. Life Science > Biotechnology

Making Oligonucleotides Better Biopharmaceuticals with Brush Polymer-Assisted Compaction

INV-16006 Background Oligonucleotide-based gene therapy holds tremendous promise for treating a variety of disorders with a genetic basis, including cancers, neurological diseases, and metabolic conditions. However, due to difficulties including poor accumulation at target sites, removal by immune responses, nuclease degradation, and low biochemical...

Published: 9/10/2024 | Inventor(s): Ke Zhang, Xueguang Lu

Keywords(s):

Category(s): -Chemistry, -Cancer, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Delivery

DNA Adductomics by Mass Tag Prelabeling

Background DNA adducts are damaged nucleotides in DNA as a consequence of its exposure to genotoxic agents or conditions. Measurement of multiple DNA adducts in a single procedure is referred to as “DNA adductomics”. In the leading analytical technique for this purpose, typically the following sequence of steps takes place starting with...

Published: 9/10/2024 | Inventor(s): Roger Giese, Poguang Wang

Keywords(s): Cancer, cancer prevention, DNA adduct, Mass Spectrometry, Mass tags, personalized medicine

Category(s): -Cancer

Green-synthesized tellurium nanowires for the growth of metallic nanoparticles on top

INV-18120 Background Traditional physicochemical approaches for the synthesis of compounds, drugs, and nanostructures are developed either as potential solutions for antimicrobial resistance or to fight against cancer. Nevertheless, these approaches have several limitations, such as the use of toxic chemicals and the production of toxic by‑products...

Published: 9/10/2024 | Inventor(s): Thomas Webster, Ada Crua, David Medina Cruz

Keywords(s):

Category(s): -Cancer, Diagnostics, Technology Classifications > 1. Life Science > Drug Delivery

Magnetic Microwires for Energy-Transporting Biomedical Applications

INV-19021 Background During the 1980s, amorphous magnetic microwires were widely used in biomedical devices. These wires are highly responsive magnetic material with unique magneto-elastic interactions, inexpensive and easy to produce in 1000s of meters. After the 1990s, new opportunities for biomedical advances elevated this class of materials...

Published: 9/10/2024 | Inventor(s): Laura Lewis, Rafael Perez del Real, Manuel Vazquez Villalabeitia, Abigail Koppes

Keywords(s):

Category(s): -Cancer, Technology Classifications > 1. Life Science > Medical Devices, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Theragnostic

Novel 3D in vivo mimicking microenvironment to deliver cell based therapy and/end evaluate new therapeutics and in vivo cell delivery methods

INV-14119 Background Most common cancer models and cell therapy are used to evaluate the efficacy of drugs at the preclinical stage. 2D monolayers have failed to mimic in‑vivo human tumor biology and do not consider the effect of tumor microenvironment when testing out the therapeutic efficacy of new drug candidates. As a result, 90% of the promising...

Published: 9/10/2024 | Inventor(s): Tania Konry, Noa Cohen, Pooja Sabhachandani

Keywords(s):

Category(s): -Devices, -Health, -Cancer, Diagnostics, Technology Classifications > 2. Physical Science > Lab tech/equipment, Technology Classifications > 1. Life Science > Drug Discovery

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