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Aqueous Formulations of Cytotoxic Taxanes with Cyclodextrin
NU 2022-109 INVENTORS Brittney Williams Matthew Thompson Nathan Gianneschi* SHORT DESCRIPTION This invention describes aqueous formulations of cytotoxic taxane drugs conjugated to fatty acids, solubilized using cyclodextrin inclusion complexes, providing water-soluble chemotherapy formulations that eliminate the need for toxic organic solvents...
Published: 2/25/2026
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Inventor(s):
Keywords(s):
Category(s):
Life Sciences > Therapeutics
Precision Neo-Cysteine Molecular Glues to Restore Protein-Protein Interactions in Disease
Application Molecular glues designed to selectively bind mutated neo-cysteine residues and restore disease-disrupted protein–protein interactions (PPIs), offering a precision therapeutic approach for conditions such as cancer where loss or weakening of critical protein interactions drives tumor growth and progression. Key Benefits Provides...
Published: 2/25/2026
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Inventor(s):
Xiulei Mo
,
Haian Fu
Keywords(s):
Oncology Treatments
,
Personalized Medicine
,
Protein and Peptide Therapeutics
,
Therapeutics
Category(s):
TechPub Algolia > Drug Discovery
Methods of Using Modified Cytotoxins to Treat Cancer
NU 2019-135 INVENTORS Nathan Gianneschi* SHORT DESCRIPTION Methods for treating cancers that overexpress fatty acid uptake proteins using small-molecule cytotoxic drugs conjugated to long-chain fatty acid moieties. See also NU2022-111. BACKGROUND While prior work (under NU2022-111) demonstrated that lipid-mimicking cytotoxin prodrugs with fatty...
Published: 2/25/2026
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Inventor(s):
Keywords(s):
Cancer/Oncology
,
Small molecule
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Identification of Biomarkers Towards Development of a Rapid Low-Cost Paper-Based Biodosimetry Triage Test
Invention Description In the event of a terrorist attack or nuclear accident where large populations of individuals are exposed to radiation, it is critical for authorities to have the ability to quantify and confirm the levels of absorbed radiation. It is also essential for authorities to identify if an individual is exposed to greater than 2Gy where...
Published: 2/24/2026
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Inventor(s):
Joshua LaBaer
,
Vel Murugan
,
Jin Park
,
Madhuranga Thilakasiri Madugoda Ralalage Don
Keywords(s):
Biomarker discovery
,
Gene Expression
,
Machine Learning
Category(s):
Medical Diagnostics/Sensors
Method for Efficient Removal of Cholesterol-Modified Transmembrane Sensors from Membranes
Invention Description In the rapidly evolving field of live-cell analysis, recent innovations have enabled the sensing and quantification of specific intracellular nucleic acid targets, such as messenger RNA (mRNA) and other RNA species, in viable cells without requiring cell lysis or destruction of the sample. This capability is critical for drug...
Published: 2/24/2026
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Inventor(s):
Rizal Hariadi
,
Ranjan Sasmal
,
Youssef Hassan
Keywords(s):
Category(s):
Medical Diagnostics/Sensors
Superconducting Diodes for Qubit Readout (Case No. 2026-079)
Summary: UCLA researchers led by Professor Pri Narang have developed a fully superconducting, on-chip readout architecture that improves signal fidelity and limits backpropagation in quantum processors Background: Superconducting quantum processors can perform complex calculations orders of magnitude quicker than classical computers. Current superconducting...
Published: 2/24/2026
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Inventor(s):
Prineha Narang
,
Arpit Arora
,
Nicolas Dirnegger
Keywords(s):
Category(s):
Electrical
,
Electrical > Quantum Computing
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Electrical > Signal Processing
,
Electrical > Sensors
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Electrical > Instrumentation
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Electrical > Computing Hardware
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Materials
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Materials > Fabrication Technologies
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Materials > Functional Materials
,
Materials > Semiconducting Materials
Superconducting Diodes for Qubit-Qubit Coupling (Case No. 2026-078)
Summary: UCLA researchers in the Department of Electrical Engineering have developed a superconducting diode-based nonreciprocal interconnect that enables low-loss, directional microwave signal routing between qubits, chips, and cryogenic modules while preserving quantum coherence and suppressing back-propagating noise. Background: Scalable superconducting...
Published: 2/24/2026
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Inventor(s):
Prineha Narang
,
Nicolas Dirnegger
,
Arpit Arora
Keywords(s):
Communication & Networking
,
cryogenic cooling
,
device architectures
,
Diode
,
Electrical Impedance
,
entanglement
,
Microwave
,
Network On A Chip
,
quantum communication
,
Quantum Computer
,
quantum network
,
quantum processing
,
quantum processor
,
scalable communication
,
transmission enhancement
Category(s):
Electrical
,
Electrical > Quantum Computing
,
Electrical > Computing Hardware
,
Energy & Environment > Energy Transmission
,
Electrical > Signal Processing
Modified Cytotoxins and their Therapeutic Use
NU 2022-111 INVENTORS Cassandra Callmann Matthew Thompson Clare LeGuyader Paul Bertin Nathan Gianneschi* SHORT DESCRIPTION This invention is for chemically modified small-molecule cytotoxic drugs conjugated to long-chain fatty acid-like hydrophobic moieties that bind non-covalently to albumin, creating improved cancer therapeutics with enhanced...
Published: 2/25/2026
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Inventor(s):
Keywords(s):
Category(s):
Life Sciences > Therapeutics
Massively Parallel Amplitude-only Optical Processing System for Machine Learning
Machine learning has become a driving force in modern technology. However, existing technology cannot keep up with its demand, due to limitations by capacitive charging of wires, system architecture that stores and handles data, and many more. Deep learning algorithms like, Convolution Neural Networks (CNN), extracts specific features of interest, using...
Published: 2/24/2026
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Inventor(s):
Mario Miscuglio
,
Volker Sorger
Keywords(s):
Category(s):
Technology Classifications > Computers Electronics & Software
,
Technology Classifications > Computers Electronics & Software > Artificial Intelligence
,
Technology Classifications > Computers Electronics & Software > Cloud Computing
,
Technology Classifications > Computers Electronics & Software > Computing Architecture
,
Technology Classifications > Computers Electronics & Software > Processing Chips
Cooperative Catalysis System for Enantioselective Transformations of Oxocarbenium Ions
NU 2019-063 INVENTORS Karl Scheidt* Mark Andrew Maskeri SHORT DESCRIPTION This invention introduces a cooperative catalysis system that enhances the reactivity and selectivity of oxocarbenium ions, facilitating new enantioselective transformations and enabling the synthesis of pharmacologically active tetrahydropyranoindole compounds. BACKGROUND...
Published: 2/24/2026
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Inventor(s):
Keywords(s):
Category(s):
Life Sciences > Therapeutics
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