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Selective DOT1L Protein Degraders for Precision Cancer Therapy

NU 2022-081 INVENTORS Sarki Abdulkadir (PI)* Gary Schiltz (PI)* SHORT DESCRIPTION A small molecule PROTAC technology that degrades DOT1L protein for targeted treatment of leukemia and prostate cancer. BACKGROUND Current cancer treatments, especially for MLL-rearranged leukemia and prostate cancer, face challenges of off-target effects and...

Published: 2/3/2026 | Inventor(s):

Keywords(s): Cancer/Oncology, Leukemia, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics.

NU 2020-217 (NU 2020-215, NU 2020-216, NU 2020-217) INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* Jindan Yu (Feinberg School of Medicine, Department of Medicine (Hematology & Oncology Division))* - **Now at Emory** SHORT DESCRIPTION Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders...

Published: 2/3/2026 | Inventor(s):

Keywords(s): Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Targeted Immune-Activating Antibody Conjugates for Cancer and Infectious Disease Therapy

This technology enables precise activation of the immune system by delivering potent TLR7/8 agonists directly to diseased cells. By combining immune stimulators with antibody targeting, it enhances therapeutic impact while minimizing systemic side effects. The approach offers a safer and more effective way to treat cancer and infectious diseases by...

Published: 2/3/2026 | Inventor(s): Lawrence Tumey, Emmanuel Olawode

Keywords(s): Technologies, XCEED

Category(s): Campus > Binghamton University, Technology Classifications > Biomedical Science and Engineering

Topological Acoustic Synapse for High-Dimensional Neuromorphic Computing

The Topological Acoustic Synapse is a neuromorphic hardware device that uses acoustic waves to perform high-dimensional neuromorphic computing. The device encodes information in a multivariate state space and uses nonlinear acoustic wave interactions to reproduce synapse-like behavior for computation. By shifting key functions from purely electronic...

Published: 2/3/2026 | Inventor(s): Xiaodong Yan, Jinli Chen, Akinsanmi Ige, Pierre Deymier, Keith Runge

Keywords(s):

Category(s): Technology Classifications > Engineering & Physical Sciences > Electronics

HistoTME: an AI tool for prediction of the tumor microenvironment molecular composition from histopathology images

HistoTME is an AI software that predicts the tumor microenvironment’s molecular makeup from standard pathology images, helping identify lung cancer patients likely to benefit from immunotherapy without needing costly molecular tests. Background: The tumor microenvironment (TME) plays a crucial role in the progression and treatment response...

Published: 2/3/2026 | Inventor(s): Tamara Jamaspishvili, Sushant Patkar, Alex Chen, Stephanie Harmon, Ismail Turkbey

Keywords(s): artificial intelligence, cancer, computational biology, digital image processing, disease diagnosis, Technologies

Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University, Technology Classifications > Medical Imaging

Atomically Dispersed Metal Catalysts And Applications Thereof

Advantages High catalytic activity and selectivity for oxygen reduction reaction (ORR) in acidic media, comparable to commercial Pt/C catalysts Atomically dispersed transition metal sites (Fe, Co, Ni, or combinations) coordinated by nitrogen, ensuring efficient and stable catalysis Hollow, porous nitrogen-doped carbon structure with high surface...

Published: 2/3/2026 | Inventor(s): Shengqian Ma, Hui Yang

Keywords(s):

Category(s): Technology Classifications > Engineering > Chemical Engineering

Fast, Accurate Measurement of the Worker Populations of Honey Bee Colonies

Invention Description Assessing honeybee worker populations is a critical index for monitoring colony health, productivity, and survivability in both agricultural and natural ecosystems. While essential for hive management, traditional population measurement techniques remain the industry standard despite being inherently labor-intensive and disruptive...

Published: 2/2/2026 | Inventor(s): Jun Chen, Junmin Zhong, Jon Harrison

Keywords(s): Agriculture and Animal Science

Category(s): Agriculture/Animal Health, Artificial Intelligence/Machine Learning, Life Science (All LS Techs)

A Novel Selective HDAC11 Inhibitor with Broad Anti-Cancer Efficacy

HDAC11 is a Histone Deacetylase (HDAC) enzyme. However, HDAC11 has a high defatty-acylase activity while its deacetylation activity is virtually nonexistent, which is linked to poor prognosis in multiple cancers. This suggests that inhibition of HDAC11 can be used to treat cancers by modulating protein function. No potent and selective inhibitors for...

Published: 2/2/2026 | Inventor(s): Edward Seto, Hening Lin

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Small Molecules

Frequency-Selective Topological Wave Switches Using Anti-Resonance Control

This technology is a materials-based method of controlling acoustic wave propagation using anti-resonance control. By integrating phase-change inclusions into acoustic metamaterials, this technology provides a material that allows bidirectional signal transport at certain frequencies and only unidirectional transport at other specific anti-resonance...

Published: 2/2/2026 | Inventor(s): Samarjith Biswas, Pierre Deymier, Keith Runge, Pierre Lucas

Keywords(s):

Category(s): Technology Classifications > Engineering & Physical Sciences > Photonics

Inhibitory Monoclonal Antibodies Against Factor XII(a) and Method of use for Treatment of Dilated Cardiomyopathy and Heart Failure

This invention details how to make and utilize monoclonal antibodies that bind to and inhibit the activity of the coagulation factor Factor XII (FXII, FXIIa) protein, and methods of use for treatment of dilated cardiomyopathy and heart failure. Background: Approximately 6.7 million Americans over 20 years of age experience heart failure, and the prevalence...

Published: 2/2/2026 | Inventor(s): Inna Gladysheva, Guy Reed

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Therapeutics

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