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Generation of Therapeutic Human Anti-Trop-2 Extracellular Domain Antibodies (UCLA Case No. 2026-026)
UCLA researchers from the Department of Molecular and Medical Pharmacology and the Department of Microbiology, Immunology and Molecular Genetics have developed a panel of human antibodies and chimeric antigen receptors targeting Trop-2, providing diagnostic and therapeutic resources for targeting Trop2-driven cancer. BACKGROUND: Trophoblast cell surface...
Published: 12/23/2025
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Inventor(s):
Tanya Stoyanova
,
Owen Witte
Keywords(s):
Category(s):
Diagnostic Markers > Cancer
,
Diagnostic Markers > Targets And Assays
,
Life Science Research Tools > Antibodies
,
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Combinatorial RNA-LNP Immunotherapy for Enhanced Pattern Recognition Receptor (PRR) Engagement, Targeted Dendritic Cell (DC) Activation, and Versatile (UCLA Case No. 2025-237)
UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a cancer immunotherapy platform that uses lipid nanoparticle (LNP) delivery of modified RNA constructs to activate dendritic cells, enhance CD8+ T-cell priming, and drive potent anti-tumor immunity. BACKGROUND: Effective cancer immunotherapy requires robust activation...
Published: 12/23/2025
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Inventor(s):
Caius Radu
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Vaccines
,
Therapeutics > Infectious Diseases
VIBRATION BASED METHOD TO ESTIMATE VISCOSITY AND DENSITY OF FLUIDS AND SOFT-SOLIDS
VAlue proposition In various applications there is a need for viscosity and density measurements of fluids and solids. Resonant sensors for the measurement of rheological properties are often employed in process and condition monitoring. Micro-acoustic MEMS devices such as micro-cantilevers and SAW devices have been previously used for such applications....
Published: 12/23/2025
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Inventor(s):
Sunil Chakrapani
,
Sarthak Desai
Keywords(s):
Category(s):
Agriculture
,
Chemicals
,
Manufacturing Equipment
,
Test and Measurement
Fire-proof Li-ion batteries enabled by a zeolite separator and a fire-resistant electrolyte
Invention Description Lithium-ion batteries serve as energy-storage media for electric vehicles, grid-scale storage systems, mobile communication devices, and equipment used in hazardous environments. However, existing lithium-ion batteries cannot yet be produced at low cost, in a scalable manner, while also meeting the requirement of being free from...
Published: 12/23/2025
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Inventor(s):
Jerry Lin
,
Kishen Rafiz
Keywords(s):
Category(s):
Physical Science
,
Energy & Power
,
Applied Technologies
Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025
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Inventor(s):
Li Li
,
Shichao Wu
,
Jiawei Zhao
Keywords(s):
Category(s):
Technology Category > Research tools
,
Technology Category > Animal models
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Technology Category > Biology
,
Technology Category > Diagnostic
Multilayer Photothermal Textile and Wearable for Thermoregulation
PRODUCT OPPORTUNITIES • Multilayer photothermal textile suitable for use in garments, apparel, upholstery, linens, and window treatments. • Personal heated wearables such as winter wear, advanced outerwear, jackets, shirts, pants, vests, gloves, hats, etc. ADVANTAGES • Lightweight photothermal...
Published: 12/22/2025
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Inventor(s):
Trisha Andrew
,
Wesley Viola
Keywords(s):
Category(s):
Engineering
,
Material science
,
Physical Science
Therapeutic backbone and scaffold modification in the physiological environment
This technology enables precise, water-based chemical modification of proteins at their C-terminus using a single, easily removable reagent, preserving protein structure and function and allowing attachment of diverse functional groups for therapeutic, research, and diagnostic applications. Background: Proteins and polypeptides play a central role...
Published: 12/19/2025
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Inventor(s):
Qiang Zhang
Keywords(s):
antibody therapy
,
GLP-1 secretion
,
Insulin
,
protein engineering
,
Technologies
Category(s):
Campus > University at Albany
,
Technology Classifications > Biomedical Science and Engineering
Enhanced Photosynthesis Efficiency for Improved Crop Productivity
Treats Plants with Mutated D1 Proteins to Boost Plant Growth Rates and Biomass This modified D1 protein enhances photosynthesis efficiency in plants, improving crop productivity and boosting overall growth rates and biomass. Photosynthesis is the fundamental process by which plants convert light energy into chemical energy, driving growth and biomass...
Published: 12/19/2025
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Inventor(s):
Xin Wang
Keywords(s):
Category(s):
Technology Classifications > Agricultural > Others
An Attenuated Vaccine for Lyme Disease
Project ID: TECH2026-05 Background Lyme disease is caused by the gram-negative spirochete Borrelia burgdorferi, as well as other Borrelia species within the Borrelia burgdorferi sensu lato group. B. burgdorferi is known to alter its virulence protein expression profiles depending on its environment. Numerous studies have shown environmental differences...
Published: 12/19/2025
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Inventor(s):
Ronald Wooten
,
John Presloid
Keywords(s):
Category(s):
Rare Disease
Dual-Genome Prediction Model for Black-Pod-Resistant Cacao
Integrates Host- and Pathogen-Genome Data in a Unified Pipeline to Evaluate Prediction Accuracy and Accelerate Breeding Decisions This dual-genome prediction model for black-pod-resistant cacao integrates host- and pathogen-genome data with phenotypic data, such as disease resistance ratings, in a unified pipeline, allowing for a detailed evaluation...
Published: 12/19/2025
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Inventor(s):
Jeremy Brawner
,
Ina Schlathoelter
Keywords(s):
Category(s):
Technology Classifications > Software > Others
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