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Technology Summary A "smart" or glucose-responsive insulin that can automatically respond to changes in a patient’s blood stream and help treat patients with type 1 diabetes. This technology comprises compositions that integrate a zwitterionic polymer, insulin moieties, saccharide moieties, and saccharide binding molecules to create...

Published: 1/9/2026 | Inventor(s): Zhiqiang Cao

Keywords(s):

Category(s): Technology Category > Biological materials, Technology Category > Chemical Processing/Synthesis, Technology Category > Drug Delivery, Technology Category > Process/Procedure, Technology Category > Small molecule, Technology Category > Therapeutics, Technology Category > Life Science

Human Tissue-Engineered Inflammatory Model of Atherosclerosis

A novel, biologically engineered human blood vessel model that accurately replicates atherosclerosis for advanced preclinical research. Technology Summary This technology creates the first authentic human tissue-level in vitro model of atherosclerosis using a proprietary ring stacking method to build three-layered blood vessels entirely from human...

Published: 1/9/2026 | Inventor(s): Mai Lam

Keywords(s):

Category(s): Technology Category > Biomedical, Technology Category > Research tools, Technology Category > Simulation & Modeling

Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells

This technology uses specially designed sulfonium lipid nanoparticles to deliver mRNA directly to lung cells through the nose, offering a non-invasive, more effective and targeted treatment for pulmonary diseases like asthma and cystic fibrosis. Background: The field of pulmonary medicine faces significant challenges in the treatment of diseases...

Published: 1/9/2026 | Inventor(s): Yamin Li, Yuqin Men

Keywords(s): active pharmaceutical ingredient, chemicals, drug delivery, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery

Échafaudage super déformable inspiré de l'origami pour l'ostéogenèse par distraction

ORIGAMI INSPIRED FLAT-FOLDABLE SCAFFOLD (OIFFS) FOR DISTRACTION OSTEOGENESIS Innovative solution to accelerate the bone healing during the distraction surgical process UNMET NEED Congenital limb asymmetry, complex long-bone fractures caused by accidents, and segmental bone loss following tumor resection are common clinical conditions that affect...

Published: 1/9/2026 | Inventor(s): Isabelle Villemure, Marie-Lyne Nault, Mohammad Ali Bagheri, Carl-Éric Aubin

Keywords(s): Healthcare, Innovation, Medical devices, Medical supplies, Medical technology

Category(s): Applications, English Applications > Health and care, Objectifs de Développement Durable > ODD 03 : Bonne santé et bien-être, Secteurs, Secteurs > Sciences de la vie, Sectors > Life sciences, Sustainable Development Goals > Goal 03: Good Health and Well-Being, Applications > Soins et santé > Traitement > Dispositifs médicaux, English Applications > Health and care > Treatment > Medical devices-T > Orthopedics-Md, Applications > Soins et santé, Applications > Soins et santé > Traitement > Dispositifs médicaux > Orthopédie

Instant, Calibration-Free Blood-Flow Measurement With A Single Optical Snapshot

A single-frame, multi-exposure time optical method enabling accurate extraction of absolute speckle decorrelation time and optimized for recovery of absolute deep-tissue blood flow. Problem: Accurately recovering absolute speckle decorrelation time without the use of calibration or complex instrumentation is challenging. For the use case of monitoring...

Published: 1/8/2026 | Inventor(s): Arjun Yodh, Wesley Baker, Joseph Majeski, Rodrigo Menezes Forti

Keywords(s): Bioengineering, Cardiovascular, Electronic Materials, Gastroenterology, Internet of Things, Nephrology and Urology, Neurology, Oncology, Ophthalmology, Optics & Photonics , Platform Technology, Surgery

Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Hardware & Components, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents, Technology Classifications > Medical Devices, Technology Classifications > Testing & Measurement

Thin film freezing technology for stable dry formulations of mRNA therapeutics

A thin film freezing method transforms mRNA and lipid nanoparticles into stable dry powders that retain their effectiveness and size. This eliminates the need for ultra-cold storage, allowing the powders to be inhaled or reconstituted, improving the distribution of mRNA therapies. Background mRNA therapeutics represent a groundbreaking advancement...

Published: 1/8/2026 | Inventor(s): Robert Williams, Chaeho Moon, Sawittree Sahakijpijarn, Haiyue Xu, Zhengrong Cui

Keywords(s):

Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Therapeutics > Drug delivery

Oral-Gut-Brain Axis Virome/Microbiome for Periodontitis, Irritable Bowel Disease and Alzheimer’s Disease Diagnostics (UCLA Case No. 2024-222)

UCLA researchers in the School of Dentistry and section of Biosystems and Function have developed a novel diagnostic protocol to accurately categorize both the virome and microbiome of the oral-gut-brain axis for periodontitis, irritable bowel disease, and Alzheimer’s disease pathologies. BACKGROUND: Humans are host to a large and diverse set...

Published: 1/7/2026 | Inventor(s): Yvonne Kapila

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

Custom Isobaric Tandem Mass Spectrometry Quantitative Chemoproteomics Enabled by Dialkoxydiphenylsilane (DADPS) Capture Reagents (UCLA Case No. 2023-113)

UCLA researchers in the Department of Biological Chemistry have developed a chemoproteomics-based method for improved and efficient protein and drug studies. BACKGROUND: Quantitative proteomics is a method scientists use to find out how much of each protein is in a sample. It is used to compare protein levels in different situations. This information...

Published: 1/7/2026 | Inventor(s): Keriann Backus

Keywords(s):

Category(s): Life Science Research Tools > Mass Spectrometry

A Solid-Phase Compatible Dialkoxydiphenylsilane (DADPS) Reagent for Chemoproteomics (UCLA Case No. 2023-017)

UCLA researchers in the Department of Biological Chemistry have developed two novel fluorenylmethyl carbamate functionalized dialkoxydiphenylsilane (FMOC-DADPS) reagents that provide unprecedented compatibility with solid-phase chemistry, enabling higher yield and purity in the synthesis of DADPS-based chemoproteomics capture reagents. BACKGROUND:...

Published: 1/7/2026 | Inventor(s): Keriann Backus

Keywords(s):

Category(s): Life Science Research Tools > Other Reagents, Life Science Research Tools > Research Methods

Spatial-Temporal Early Fatigue Prediction in Additively Manufactured Metals

Invention Description Additive manufacturing (AM) can transform the production of engineered components, offering performance advantages over traditional methods. Metallic cellular materials produced by AM are of growing interest for aerospace, biomedical, and automotive applications due to their lightweight and multifunctional nature. Fatigue life...

Published: 1/7/2026 | Inventor(s): Tyler Smith, Dhruv Bhate, Shenghan Guo

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Physical Science, Manufacturing/Construction/Mechanical

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