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All-in-One Safety Trocar (Device) System for Controlled Access to Internal Body Cavities

Accessing internal body cavities for drainage, diagnostic sampling, or device placement is critical in thoracic, abdominal, and pelvic procedures—but current methods are complex and risky. Traditional approaches require multiple instruments and manual steps, increasing tissue trauma, procedure time, and complication rates. Even advanced trocar...

Published: 11/14/2025 | Inventor(s):

Keywords(s):

Category(s): Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Surgical

Novel Heat Exchanger Design for Enhanced Air Cooling

Invention Description There is a well-recognized need to broadly decrease the amount of water used for evaporative (wet) cooling in many applications, especially in power generation, but also in emerging cutting-edge technologies, such as data and supercomputing centers. The main challenge in dry cooling using ambient air is the inevitable temperature...

Published: 11/14/2025 | Inventor(s): Ivan Ermanoski

Keywords(s): Energy, Energy Efficiency

Category(s): Energy & Power, Manufacturing/Construction/Mechanical, Physical Science

Aerodynamic and vibration damping skin for cylindrical structures

Unit cell of locally-resonant lattice tuned to damp noise source. Invention Summary: During rocket launches and stage separations, intense vibrations and shock waves can damage sensitive payload electronics. Traditional isolation systems are often heavy and increase fuel consumption, making lightweight vibration-damping solutions essential....

Published: 11/14/2025 | Inventor(s): Jonathan Singer, Andrew Norris, Catherine Nachtigal, Bryan Llumiquinga, Matthew Kelsten, Paul Hoffecker

Keywords(s):

Category(s): Technology Classifications > Physical Sciences & Engineering

Hydrophilic Asn-Asn-Linker Adcs for Potent and Stable Targeted Immunotherapy

This invention introduces hydrophilic TLR7 agonist antibody drug conjugates using a short Asn Asn linker that improves solubility, stability, and pharmacokinetics. By enabling precise site specific conjugation with reduced aggregation and strong innate immune activation, the platform delivers potent antitumor responses across multiple solid tumor indications. Background:...

Published: 11/14/2025 | Inventor(s): Lawrence Tumey, Mohan Mullapudi

Keywords(s): Technologies

Category(s): Campus > Binghamton University

Dual Payload Antibody Conjugates for Combined Cytotoxic and Immune Stimulatory Cancer Therapy

This invention introduces a dual payload antibody drug conjugate platform that delivers both a potent cytotoxic agent and a TLR7 agonist to tumors with controlled, site specific attachment. By uniting targeted cell killing with localized immune activation in a single biologic, the approach improves therapeutic index, overcomes resistance, and enhances...

Published: 11/14/2025 | Inventor(s): Lawrence Tumey, Victor Ojo

Keywords(s): Technologies

Category(s): Campus > Binghamton University

Enzymatic Bioluminescent Beacons for Ultra-Sensitive, Rapid Nucleic Acid Detection

This invention introduces enzymatic bioluminescent beacons that generate bright, low-background light only upon binding their target sequence. A site-specific ligation strategy forms uniform 1 to 1 nanoluciferase–hairpin conjugates, enabling rapid, picomolar sensitivity detection with precise single-base discrimination in streamlined, equipment-light...

Published: 11/14/2025 | Inventor(s): Brian Callahan

Keywords(s): Technologies

Category(s): Campus > Binghamton University

Method and Apparatus for Improving the Signal-To-Noise Ratio in Multi-Dimensional Magnetic Resonance Imaging Data (Case No. 2025-204)

Summary: UCLA researchers have developed a software-based denoising method that makes cardiac MRI images clearer and more reliable, enabling more accurate heart function measurements without requiring longer scan times. Background: Cardiac MRI is a powerful imaging tool for assessing heart health because it can provide detailed pictures of how the...

Published: 11/13/2025 | Inventor(s): Xiaodong Zhong, Shu-Fu Shih, Holden Wu, Kim-Lien Nguyen

Category(s): Medical Devices > Cardiac, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Software & Algorithms > Image Processing, Software & Algorithms

Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors

Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80...

Published: 11/13/2025 | Inventor(s): Yong Wan, Yueming Zhu, Ivet Bahar, Anupam Banerjee, Jiyoung Lee

Keywords(s): Drug Target Identification, Immunotherapy, Oncology Treatments, Small Molecule, Therapeutics

Category(s): TechPub Algolia > Drug Discovery

Ultra Black and Ultra White Coating on Different Sides of a Wind Turbine Blade to have Additional Energy from Solar

This invention aims to improve the efficiency and power output of wind turbines using additional energy from sunlight. The pressure side of each wind turbine blade is coated ultra black, and the suction side of each wind turbine blade is coated ultra white. When sunlight shines on the turbine, these coatings cause the light to contribute to the rotational...

Published: 11/13/2025 | Inventor(s): Peiwen Li

Keywords(s):

Category(s): Technology Classifications > Energy, Cleantech & Environmental > Renewable Energy > Wind, Technology Classifications > Energy, Cleantech & Environmental > Renewable Energy, Technology Classifications > Materials > Coatings

Multiomic Approaches to Pediatric Inflammatory Bowel Disease

Invention Description Pediatric Inflammatory Bowel Disease (IBD), encompassing Crohn’s Disease and Ulcerative Colitis, presents significant clinical challenges due to its complex and heterogeneous nature, often leading to lifelong health complications. Current diagnostic and therapeutic strategies are limited by an incomplete understanding of...

Published: 11/12/2025 | Inventor(s): Todd Sandrin, Peter Jurutka, Haiwei Gu, Brad Pasternak

Keywords(s):

Category(s): Applied Technologies, Diagnostic Assays/Devices, Life Science (All LS Techs), Pharmaceuticals, Proteomic Assays/Reagents/Tools

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