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UCHL1 Inhibitors, Modifications, and Uses Thereof (UCLA Case No. 2026-123)
UCLA researchers in the Department of Molecular & Medical Pharmacology and have developed novel, highly potent small-molecule inhibitors of UCHL1 that selectively suppress tumor growth and metastasis in aggressive cancers with favorable in vivo safety profiles. BACKGROUND: Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a dual-function enzyme...
Published: 3/11/2026
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Inventor(s):
Tanya Stoyanova
,
Michael Jung
Keywords(s):
Category(s):
Diagnostic Markers > Cancer
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Therapeutics > Oncology
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Therapeutics > CNS and Neurology
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Therapeutics > Oncology > Oncology (Small Molecules)
Metastable Atom in Resonator for Laser Isotope Separation (MARLIS)
MARLIS is a new laser-based technology that efficiently separates atomic isotopes by using long-lived atomic states and a powerful optical resonator, making the process more reliable, compact, and energy-efficient than previous methods. Background Isotope separation is a critical process in fields such as nuclear energy, medical diagnostics, and...
Published: 3/11/2026
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Inventor(s):
Mark Raizen
Keywords(s):
Category(s):
Physical sciences > Materials > Isotopes
Aptamer-based field diagnostics for infectious PRRSV and PEDV detection
Background Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV) are two of the most economically destructive viruses impacting the global swine industry. These pathogens cause severe illness and death in pig populations, leading to reduced productivity, increased veterinary expenses, and trade restrictions....
Published: 3/11/2026
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Inventor(s):
Yi Lu
,
Whitney Lewis
Keywords(s):
Category(s):
Life sciences > Agriculture > Animal/veterinary
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Life sciences > Diagnostic
A Connector and Gas-Liquid Separator for Combined Electrical Submersible Pumps (ESP) and Beam Lift or Progressing Cavity Pumps (PCP)
Background In the field of hydrocarbon production, artificial-lift systems are used to enhance the extraction of oil and gas from reservoirs. As reservoirs deplete over time, their natural pressure diminishes, making it increasingly difficult to bring hydrocarbons to the surface. Artificial-lift techniques, which include the use of pumps and gas injection,...
Published: 3/11/2026
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Inventor(s):
Paul Bommer
Keywords(s):
Category(s):
Physical sciences > Process instrumentation
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Physical sciences > Energy > Oil & gas > Upstream oil & gas
A Look-Up-Table Based Control Architecture and Data Aggregation Methodology for Rapid Development and Deployment of Drilling Automation Solution
Background The field of oil and gas well construction involves complex drilling processes that require precise control and monitoring to ensure safety and efficiency. Automation in this field is increasingly being explored to address the challenges posed by the harsh and variable conditions of drilling environments. The need for advanced technology...
Published: 3/11/2026
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Inventor(s):
Pradeepkumar Ashok
,
Eric van Oort
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Adrian Ambrus
,
Parham Pournazari
,
Roman Shor
Keywords(s):
Category(s):
Physical sciences > Energy > Oil & gas > Upstream oil & gas
Targeted pH Sensitive Liposomes
NU 2020-170 INVENTORS Leo Gordon* Dong-Hyun Kim* Shuo Yang Wooram Park Taehoon Sim SHORT DESCRIPTION Liposomal nanoparticles composed of pH-sensitive lipids and apolipoprotein that encapsulate andrographolide for lymphoma treatment. BACKGROUND Lymphoma, particularly diffuse large B-cell lymphoma (DLBCL), is the most common aggressive type...
Published: 3/11/2026
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Inventor(s):
Keywords(s):
Blood & Lymphatic disease
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Cancer/Oncology
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Nanoparticle
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Therapeutics
Category(s):
Life Sciences > Therapeutics
MILLI-RADIAN ULTRAFAST LASER PULSE METROLOGY
VAlue proposition Ultrashort laser pulses have seen widespread use in scientific, medical, and industrial fields. Their degree of coherence is a key feature that dictates the accuracy and amount of noise in its applications. The relative spectral phase within the bandwidth of the pulse needs external methods to measure and control. Controlling the...
Published: 3/11/2026
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Inventor(s):
Marcos Dantus
,
Jacob Stamm
,
Jorge Mogrovejo
Keywords(s):
Category(s):
Analytical Instruments
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Photonics
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Test and Measurement
Polybenzimidazoles Based on Monomers Derived from 4,4'-Dichlorodiphenyl
Background The field of high-temperature gas separation membranes is critical for various industrial applications, including energy production and chemical processing. One of the most important applications is the separation of hydrogen (H2) from carbon dioxide (CO2), which is essential for processes like hydrogen production and carbon capture and...
Published: 3/11/2026
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Inventor(s):
Benny Freeman
,
James McGrath
,
Judy Riffle
Keywords(s):
Category(s):
Physical sciences > Materials > Membranes
A Magnetically Steerable Guidewire for Neuro-Endovascular Intervention
Background Neuro-endovascular intervention for acute ischemic stroke caused by large vessel occlusion relies on precise guidewire navigation through narrow, tortuous, and fragile cerebral vessels to perform mechanical thrombectomy (MT). Although MT has become the gold standard for restoring blood flow, navigating to the clot is technically demanding...
Published: 3/11/2026
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Inventor(s):
Farshid Alambeigi
,
Tarunraj Mohanraj
,
Hamidreza Saber
Keywords(s):
Category(s):
Life sciences > Medical technology > Medical devices
Open Resource Library
Summary: The Open Resource Library (ORL) is an innovative, web-based platform designed to centralize and promote open-source educational resources within the University of Vermont and beyond, fostering collaboration and ease of contribution. Technology overview: The ORL is an accessible, user-friendly digital repository that organizes educational...
Published: 3/11/2026
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Inventor(s):
Kendall Fortney
Keywords(s):
Category(s):
Technology Classifications > Education & Training
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Technology Classifications > Miscellaneous & Other
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Technology Classifications > Information Technology > Software & Data
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Technology Classifications > Information Technology
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Technology Classifications > Open Source
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