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Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance

SHORT DESCRIPTION A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance. INVENTORS Edward Thorp* Northwestern University Feinberg School of Medicine, Department of Pathology Evan Scott* McCormick School of Engineering, Department...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation

Category(s): Life Sciences > Therapeutics

Targeting Autoimmunity-Associated T cells via AHR Pathway Control

SHORT DESCRIPTION Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity. INVENTORS Jaehyuk Choi* Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)** Deepak Rao Brigham and Women's...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Autoimmune disease, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Antisense oligonucleotides to prevent genetic mis-splicing for ALS/FTD therapeutics

SHORT DESCRIPTION Antisense oligonucleotides (ASOs) that correct TDP‑43–dependent mis‑splicing of KCNQ2 thereby reducing neuronal hyperexcitability in ALS/FTD and related TDP‑43 proteinopathies. INVENTORS Evangelos Kiskinis* Northwestern University Feinberg School of Medicine, Department of Neurology Jonathan...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): ALS - Amyotrophic Lateral Sclerosis, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurologic disease, Neurology, Nucleic Acids, Rare diseases, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Incomplete Autophagy Induction for the Treatment of Cancer

SHORT DESCRIPTION This incomplete autophagy inducer triggers caspase-mediated apoptosis in cancer cells by inducing incomplete autophagy, leading to tumor reduction and improved survival. INVENTORS INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Jawad...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Lung cancer, Melanoma, Repurposed Drugs, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Once-Weekly Glucocorticoid Steroid Dosing for Enhanced Muscle Function and Metabolic Health

SHORT DESCRIPTION A glucocorticoid regimen that preserves the benefits of steroids on muscle mass and function while mitigating many of the metabolic and growth‑related toxicities seen with daily dosing in various inflammatory, autoimmune, respiratory, and neuromuscular disease settings. INVENTORS Elizabeth McNally*, MD, PhD Northwestern...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Aging, DMD - Duchenne muscular dystrophy, Immunology, Inflammation, Metabolic disorders, Muscle metabolism, Rare diseases, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Northwestern Startup: Acumen Pharmaceuticals, Inc.

Founded: 1996 Northwestern Inventor: William Klein Weinberg College of Arts and Sciences Department of Neurobiology and Physiology Grant Krafft Feinberg School of Medicine Department of Molecular Pharmacology and Biological Chemistry Acumen Pharmaceuticals develops therapeutics for Alzheimer's Disease (AD) based upon the discovery and characterization...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Antibody, Neurodegenerative disease, Neurologic disease, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT

Novel ZnO Nanowire-Based Hybrid Nanocarrier for Cancer Drug and Gene Delivery

This invention relates to a novel tri-component nanocomposite system comprising commercially available zinc oxide nanowires (ZnO NWs) functionalized to simultaneously deliver both small-molecule drugs and genetic material to cancer cells. This hybrid nanocarrier platform addresses critical limitations of current cancer therapies, including poor tumor...

Published: 5/6/2026 | Updated: 5/6/2026 | Inventor(s): Prashant Sharma, Mario Otto

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics

ERG-7 Inhibitors: Targeting the Sterol Biosynthetic Pathway

This invention relates to small molecule anti-fungal compounds, pharmaceutical compositions, and methods of use for the prevention, treatment, or mitigation of fungal diseases in human and veterinary subjects. In particular aspects, the invention provides inhibitors that modulate fungal sterol biosynthesis, including inhibitors of lanosterol synthase...

Published: 5/6/2026 | Updated: 5/6/2026 | Inventor(s): Rui Xiong, Hongmin Li, Malla Reddy Gannarapu, Divakar Indukuri, Anil Tharappel, Ke Chen, Mengjiao Ma

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

Multi-Targeted Kinase Inhibitors Towards AML and Other Cancers

This invention relates to small-molecule compounds that are potential therapeutics for Acute Myeloid Leukemia (AML), specifically AML with the FMS-like tyrosine kinase 3 (FLT3) mutation. The compounds also show activity versus Abl kinases, platelet-derived growth factor receptor (PDGFR), and the dual-specificity tyrosine regulated/Cdc2-like (DYRK/CLK)...

Published: 5/6/2026 | Updated: 5/6/2026 | Inventor(s): Christopher Hulme, Alessandra Fistrovich, Samantha Rokey, Aidan McMahon, Timothy Chavez, Jennifer Carew

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

Northwestern Startup: NanoAl (Acquired by Braidy Industries)

Founded: 2013 Northwestern Inventor: David C. Dunand McCormick School of Engineering and Applied Sciences Department of Materials Science and Engineering Faculty Profile David N. Seidman McCormick School of Engineering and Applied Sciences Department of Materials Science and Engineering Faculty Profile NanoAl, LLC, is a technology company dedicated...

Published: 5/5/2026 | Updated: 5/5/2026 | Inventor(s):

Keywords(s): Metals, Startup with Northwestern IP

Category(s): Physical Sciences > Materials and Industrial Processes

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