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Chemokine Receptor CCR1 as a New Therapeutic Target to Improve Hemorrhagic Shock Resuscitation
Advantages Significant reduction in fluid requirements without noticeable adverse events Clinically tested compound for multiple sclerosis, demonstrating favorable safety and tolerability profile Mitigation of inflammation and tissue edema Broad market potential in major surgeries, sepsis, burn care, and military medicine, where fluid management...
Published: 8/18/2025   |   Inventor(s): Matthias Majetschak, Xianlong Gao, Elizabeth Cook
Keywords(s): Critical Care / Trauma, Surgery
Category(s): Technology Classifications > Medical > Surgery, Technology Classifications > Medical > Therapeutics
Methionine Sulfoxide Reductase A (MsrA) Gene Therapy for Retinal Degeneration
Advantaages Targeted Protection Against Oxidative Stress Dual-Vector Delivery System (AAV and Lenti) Simple and scalable plasmid design for efficient production Suitable for major ophthalmology indications: Age-related macular degeneration (AMD), Retinitis pigmentosa, other oxidative stress-related retinal degenerations Summary Oxidative stress...
Published: 8/18/2025   |   Inventor(s): Manas Biswal
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Method and Apparatus for Segmentation of Dense MR Images Using Deep Learning with Domain Adaptation (Case No. 2025-208)
Summary: UCLA researchers from the Department of Radiological Sciences have developed a deep learning-based segmentation framework that enables fully automated and reproducible analysis of left ventricular (LV) function in Displacement Encoding with Stimulated Echoes (DENSE) MRI. Background: Myocardial strain is a key metric for analyzing how much...
Published: 8/15/2025   |   Inventor(s): Xiaodong Zhong, Siyue Li, Kim-Lien Nguyen
Keywords(s): acute myocardial infarction, adjustable mount, aneurysm drainage, automatic leveling, bedside decisions, blood pressure monitoring, cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, Cardiac MRI, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular monitoring, cerebrospinal fluid (CSF) drainage, Cine MRI, clamp, critical-care, CSF drainage, Deep learning MRI, DENSE MRI, laser alignment, Left ventricular segmentation, lumbar drains, Motion analysis, MRI, multiparametric MRI (mpMRI), Myocardial strain, non-invasive cardiac monitoring, operator variability, passive reflective target, phlebostatic axis measurement, Pseudo-labeling, radial MRI, Segment Anything Model (SAM), self-leveling system, transducer alignment, Unsupervised domain adaptation (UDA)
Category(s): Medical Devices > Cardiac, Electrical > Imaging, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Medical Imaging > MRI, Medical Devices > Medical Imaging
Chimeric Antigen Receptor Therapy Targeting Misfolded Proteins for Neurodegenerative Disease Treatment
In Alzheimer's disease and related dementias (ADRD), cells in the brain generate more misfolded/toxic protein variants than they can clear. The resultant toxic protein variants can kill neurons, and depending on which protein variants and which brain regions, can lead to AD or other ADRDs, or combinations of these diseases. There have been a significant...
Published: 8/15/2025   |   Inventor(s): Michael Sierks
Keywords(s):  
Category(s): Allogenic Cell Therapy, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Pharmaceuticals
A Compact Alignment Tool for Accurate Hemodynamic Monitoring: CardioAxis (Case No. 2025-294)
Summary: UCLA Biodesign researchers have created a laser-powered, self-leveling device that enables precise intracranial pressure monitoring and accurate phlebostatic axis measurement for hemodynamic monitoring. Background: Hemodynamic monitoring is crucial for measuring the delivery of blood and oxygen throughout the body and provides invaluable...
Published: 8/15/2025   |   Inventor(s): Sneha Shaha, Michael Malig, Sukhneet Dhillon
Keywords(s): adjustable mount, aneurysm drainage, arterial blood pressure (ABP), automatic leveling, bedside decisions, blood flow management, Blood Pressure, blood pressure monitoring, central venous pressure (CVP), cerebrospinal fluid (CSF) drainage, clamp, Continuous blood pressure monitoring, critical-care, CSF drainage, hemodynamic monitoring, Hemodynamics, intracranial pressure, laser alignment, lumbar drains, operator variability, passive reflective target, phlebostatic axis measurement, pressure sensitive, pulmonary arterial pressure (PAP), self-leveling system, transducer alignment
Category(s): Medical Devices, Medical Devices > Hospital Systems, Medical Devices > Surgical Tools
Magnetic Field-Assisted Finishing Composition
Executive Summary Magnetic field-assisted finishing (MAF) is a machining process which utilizes a magnet, ferrous materials, abrasive materials, and an oil to create a ‘brush’ for polishing operations. The process allows automation of surface finishing without the need for manual polishing. However, the quality of the finishing is highly...
Published: 8/15/2025   |   Inventor(s): Haseung Chung duplicate record, Patrick Kwon
Keywords(s): Graphite Nanoplatelets, Nanoplatelet
Category(s): Manufacturing Equipment, Materials
Lignin-Based Separators for Lithium-Ion Batteries
Executive Summary Lithium ion batteries are currently ubiquitous in numerous applications. In these batteries, the separator plays a crucial role by physically separating the anode and cathode to prevent electrical short circuits while allowing the flow of ions through the electrolytes. Common materials used for separators include polyolefins such...
Published: 8/15/2025   |   Inventor(s): Chengcheng Fang, Huanhuan Jia
Keywords(s): Lignin, Lithium Batteries
Category(s): Advanced Materials, Energy
Hybrid Lithium-Ion / Lithium-Metal Battery Electrolyte for Fast Charging and High Energy Density
Executive Summary Lithium ion batteries are currently ubiquitous in numerous applications while lithium metal batteries are becoming closer to commercialization. For all batteries, there is a continuous need for higher energy density and fast charging and discharging due to growing applications such as e-vehicles. One limitation of lithium based batteries...
Published: 8/15/2025   |   Inventor(s): Chengcheng Fang, Robert Kuphal
Keywords(s): Lithium Batteries
Category(s): Energy, Materials, Mobility
Graphene-Reinforced Polymer Matrix Composites
​ Invention Summary: Despite the increasing demand for low-cost, light weight and high-performance materials across various industries, most polymer materials lack these properties. Graphene offers a promising solution by enhancing the electrical and thermal conductivity property as well as mechanical strength when added to the polymer. However,...
Published: 8/15/2025   |   Inventor(s): Stephen Tse, Thomas Nosker, Jennifer Lynch-Branzoi, Bernard Kear, Gordon Chiu, Justin Hendrix
Keywords(s): Graphene technology, Polymers & Composites
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials
Smart Metal-Graphene Hybrid Reflectarray at THz Frequencies
­Four technologies work in unison (source, modulator, antenna, reflector) to increase the propagation of upper band 5G (i.e., 100 to 300 GHz). Background: In order to continue the exponential rise in wireless data rates, terabit-per-second links are expected to become a reality within the next five years. The exploration of higher frequency bands,...
Published: 8/15/2025   |   Inventor(s): Erik Einarsson, Josep Jornet, Arjun Singh, Ngwe Thawdar, Michael Andrello
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Electronics, Technology Classifications > Wireless Technologies
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