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Targeting RNA Polymerase I Protein–Protein Interfaces Using Peptide Inhibitors: A Computational Strategy Powered by PepTelligence, a Comprehensive Peptide Scoring System
PepTelligence is an innovative computational tool designed to evaluate and optimize therapeutic peptides by integrating multiple biochemical and pharmacological factors into a unified scoring system. Background: The development of PepTelligence addresses a significant challenge in peptide drug discovery: the absence of a comprehensive evaluation...
Published: 2/24/2026   |   Inventor(s): Maryam Kabiri, Bruce Knutson
Keywords(s): multi-parameter scoring, peptide design, peptide drug discovery, peptide scoring system, structural bioinformatics, Technologies, therapeutic peptides
Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
Novel Serotonin Receptor Agonist to Treat Neurological Disease
NU 2018-135 INVENTORS Karl Scheidt* Adam Csakai Herbert Meltzer SHORT DESCRIPTION A novel small molecule that selectively targets serotonin 5-HT2c receptors for the treatment of psychiatric, mental, and/or neurological diseases. BACKGROUND Serotonin is a neurotransmitter known to regulate a variety of neurological functions, and alterations in...
Published: 2/23/2026   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Method for the synthesis of heteroyohimbine natural products
NU 2015-009 INVENTORS Karl Scheidt* Herbert Meltzer Ashkaan Younai Bi-Shun Zeng SHORT DESCRIPTION Enantioselective synthetic methods for preparing heteroyohimbine alkaloid intermediates using a novel cooperative hydrogen bonding/enamine-catalyzed Michael addition reaction as a key step to access complex natural products, including alstonine...
Published: 2/23/2026   |   Inventor(s):  
Keywords(s): Drug discovery, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Efficient Electrode Integration for Microfluidic Diagnostics
Application A manufacturing approach for creating microfluidic devices used in disease modeling, diagnostics, and other lab on a chip applications. Key Benefits Supports high‑performance microfluidic workflows requiring strong, reliable, and reusable device assemblies. Compatible with complex device designs, enabling flexible integration of sensors,...
Published: 2/23/2026   |   Inventor(s): Priscilla Delgado, David Myers, Martin Tomov
Keywords(s): Instrumentation, Lab-on-a-Chip Devices, Micro and Nanotechnology, Microfluidics, Production Methods
Category(s): TechPub Algolia > Diagnostics
Next Gen Immune-Optimized Gene Delivery
Application An advanced gene therapy approach that improves therapeutic efficiency by protecting transgene expressing cells from host immune responses, through modulation of a key immune checkpoint pathway. Key Benefits Enhanced efficiency across viral and non-viral gene delivery systems, including AAV, lentivirus, LNPs, and electroporation. Enables...
Published: 2/23/2026   |   Inventor(s): Matthew (Matt) Gardner, Michael Kuipa, Abubakarr Koroma, Isai Leguizamo
Keywords(s): Biologics, Cell Therapy, Gene Therapy and Editing, Immunology and Inflammation Treatments, Oncology Treatments, Platform, Regenerative Medicine
Category(s): TechPub Algolia > Therapeutics
Rare-earth Doped Nanocomposite Materials for Photonics Applications
Invention Summary: An esteemed Rutgers University Professor of Materials Science has developed an optically transparent composite material comprised of highly Rareearth- doped solid solution inorganic nanoparticles. These nanocomposite particles can be dispersed in a matrix of polymers, glass, liquid, or crystalline material. The nanoparticles are constructed...
Published: 2/23/2026   |   Inventor(s): Richard Riman, John Ballato
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials
Site-Specific Synthesis of 2D TMDs for High-Performance Nanoelectronic Devices
A lithographically defined, transfer-free CVD process enables site-specific growth of MoS₂ directly on CMOS-compatible SiO₂/Si substrates using patterned MoO₃ as both precursor and high-k dielectric. The approach delivers tunable crystallinity, improved interface quality, and enhanced FET performance while eliminating post-growth transfer and etching...
Published: 2/23/2026   |   Inventor(s): Huamin Li, Fei Yao, Gabriel Lee, Keith Wong, Ajay Yadav, Chu-Te Chen, Anthony Cabanillas
Keywords(s): Materials & Chemicals, Semiconductor and Microprocessing, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Electronics, Technology Classifications > Nanotechnology, Technology Classifications > Materials and Chemicals
Ambient-Temperature Direct Air Capture of Carbon Dioxide
Novel amine-based sorbents for carbon dioxide capture with enhanced oxidative and thermal stability BACKGROUND: Anthropogenic climate change presents an urgent threat to ecosystems, public health and economic stability. Even single degree increases in global temperatures can trigger irreversible impacts, ranging from biodiversity loss and food insecurity...
Published: 2/23/2026   |   Inventor(s): Miao Yu, Kaleb Friedman
Keywords(s): Chemistry, Energy, Environment, Materials & Chemicals, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Environment, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
Engineered prodrug with tumor-selective delivery for targeted glycolysis inhibition.
Engineered prodrug with tumor-selective delivery for targeted glycolysis inhibition A conjugate of 2-deoxy-D-glucose and a fatty acid forms albumin-binding nanoparticles that enter cancer cells via glucose and fatty acid transporters, inhibit glycolysis, and induce tumor-selective cell death with enhanced potency and targeting. Background The...
Published: 2/23/2026   |   Inventor(s): Cassandra Callmann, Sungjin Jeon
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Drug delivery
Barium Titanate - Yttria-Stabilized Zirconia Hybrid Bioceramic: A Synergistic Platform for Structural Reinforcement and Bioelectric Stimulation for Smart Implantable Medical Devices
Advantages Combines high mechanical strength with bioelectric functionality in a single ceramic material Enables self-powered operation by harvesting energy from physiological motion Maintains long-term durability suitable for load-bearing implant applications Supports biocompatibility and favorable cell interaction for medical use Tunable composition...
Published: 2/23/2026   |   Inventor(s): Albert Kim, Geelsu Hwang, Sophia Selvarajan
Keywords(s): Medical Implants
Category(s): Technology Classifications > Advance Materials, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Medical Sensors
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