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Enhanced Therapeutic Effect of Armored CAR-T Cells for the Treatment of Glioblastoma (UCLA Case No. 2024-066)

UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have engineered chimeric antigen receptor (CAR)-T cells that co-express defined immunostimulatory cytokines to enhance therapeutic efficiency against glioblastoma (GBM). BACKGROUND: Glioblastoma Multiforme (GBM) is the most common primary malignant brain tumor...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s): Yvonne Chen

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > CNS and Neurology

Continuous Kidney and kidney Allograft Monitoring Using a Novel wireless implanted Sensor.

SHORT DESCRIPTION A device to monitor transplanted organs and detect early signs of rejection BACKGROUND End-Stage Renal Disease (ESRD) is a major health and financial problem in the United States. Kidney transplantation is the treatment of choice for ESRD patients, however, the 5-year kidney allograft survival rate is around 72-75%. Rejection...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s):

Keywords(s):

Category(s): Life Sciences > Healthcare Devices, Tools & IT

Microfluidic Lung Chip For Development Modeling

A microfluidic lung chip applies controlled mechanical forces to hydrogel-embedded lung cells or organoids to model lung development in vitro. Problem: Developing lung tissues experiences dynamic mechanical forces during organogenesis. How these forces influence later-stage lung development remains poorly understood. Existing models have not adequately...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s): Dongeun (dan) Huh, Sunghee Estelle Park

Keywords(s): Bioengineering, Pulmonary

Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents

Programmable intracellular RNA scaffolds for integrating sensing and regulation

Co-transactionally folded RNA nanostructures in living cells. Invention Summary: Biomarker validation and intracellular RNA detection require tools that are precise, scalable, and capable of capturing complex gene expression patterns. Current approaches, including CRISPR-based systems, RNA interference, and RNA sponge technologies, are often...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s): Fei Zhang, Xu (leo) Chang, Jean-Pierre Etchegaray, Maciej Jeziorek

Keywords(s):

Category(s): Technology Classifications > Healthcare & Life Sciences

Plasma-Enhanced Catalytic Reactor for Selective Methane-to-Methanol Conversion

INVENTORS Dayne Swearer* James Ho * Principal Investigator NU 2024-211 IP STATUS PCT patent application filed DEVELOPMENT STAGE TRL-4 Prototype Validated in Lab: Key functions have been demonstrated in a laboratory-scale prototype. BACKGROUND Methane conversion to methanol is challenging due...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s):

Keywords(s):

Category(s): Physical Sciences > Energy & Sustainability

A Device for Fast and Convenient Assessment of Micro-volume Liquid Dispensing Performance

This technology is a device designed to enable rapid, consistent, and standardized assessment of micro-volume liquid dispensing performance across manual, automated, and robotic workflows. The device provides a controlled and reproducible surface for droplet deposition, incorporating defined features and optional calibration elements that allows for...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s): Chi Zhou

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Category(s): Technology Classifications > Research Tools, Technology Classifications > Software & Information Technology > Education & Training, Technology Classifications > Creative Works & Copyright, Technology Classifications > Medical Devices

Image-Based Droplets Analysis Systems/Methods for Operator Performance Assessment

This technology is an image-based analytical platform that enables quantitative, standardized assessment of liquid dispensing performance across manual, automated, and robotic laboratory workflows. The invention is based on the recognition that droplet formation patterns contain measurable signatures of dispensing behavior. By capturing droplet arrays...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s): Chi Zhou

Keywords(s):

Category(s): Technology Classifications > Software & Information Technology > Education & Training, Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Creative Works & Copyright, Technology Classifications > Research Tools

Monoclonal, Inducible, and Traceable Mesenchymal Stem Cell Platform for Cell Therapy

This figure illustrates the engineered Mesenchymal Stem Cells are monoclonal, conditionally immortalized (inducible), non-tumorigenic, and traceable in vitro and in vivo (bioluminescent imaging). The engineered MSCs have maintained their multipotency and chemotaxis capability (tumor targeting). The developed MSC platform is capable of delivering...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s): Arash Hatefi, Mohammad Massumi

Keywords(s):

Category(s): Technology Classifications > Healthcare & Life Sciences

3D MITHRIL – APPLICATEUR EN COTTE DE MAILLES POUR LA PLÉSIOTHÉRAPIE

MESH APPLICATOR FOR SURFACE BRACHYTHERAPY Novel applicator designed to facilitate and accelerate the clinical workflow of surface brachytherapy UNMET NEED It is estimated that about 1.2M people are diagnosed with skin cancer every year. Despite the progress in therapy development, the death rate from skin cancer remains significant, especially...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s): Stéphane Bedwani

Keywords(s): Innovation

Category(s): Applications > Soins et santé > Traitement > Dispositifs médicaux > Radiothérapie, Applications > Soins et santé > Traitement > Dispositifs médicaux > Oncologie, Sustainable Development Goals > Goal 03: Good Health and Well-Being, Objectifs de Développement Durable > ODD 03 : Bonne santé et bien-être, Applications > Soins et santé > Traitement > Dispositifs médicaux, English Applications > Health and care > Treatment > Medical devices-T

Protecting Proprietary Designs via Adversary-Aware Decoy Generation

SHORT DESCRIPTION A computational tool that safeguards proprietary protein designs by generating biochemically plausible decoy proteins to mislead adversaries. INVENTORS V.S. Venkatramanan Subrahmanian, PhD* Walter P. Murphy Professor of Computer Science, Department of Computer Science, McCormick School of Engineering,...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s):

Keywords(s): Artificial Intelligence & Machine Learning, Biotechnology

Category(s): Physical Sciences > Software & Services, Physical Sciences > Engineering & Technology, Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT

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