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Genetically engineered cell surface biosensors for high-throughput detection, screening, and recovery of rare earth elements

This technology uses genetically engineered yeast cells displaying fluorescent sensors to detect and recover rare earth elements from solutions, enabling rapid, specific, and scalable metal screening and extraction using fluorescence signals and high-throughput sorting. Background Rare earth elements (REEs) are a group of 17 chemically similar metals...

Published: 3/30/2026 | Updated: 3/30/2026 | Inventor(s): Manish Kumar, Marcus Benyamin, Steven Zilko, Andrew Ellington, Benjamin Keitz, Randall Hughes

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Synthetic biology

Targeting EGFR Co-Amplified Long-Noncoding RNA for Glioblastoma Treatment

NU 2025-335 INVENTORS Shi-Yuan Cheng* Xiaozhou Yu Bo Hu Runxin Wu Xiao Song SHORT DESCRIPTION This invention provides compositions and methods for inhibiting ELDR and HELDR, two long non-coding RNAs (lncRNAs) that are frequently co-amplified in glioblastoma (GBM) with the epidermal growth factor receptor (EGFR) gene, and which drive tumorigenesis...

Published: 3/30/2026 | Updated: 3/30/2026 | Inventor(s):

Keywords(s): Brain cancer, Cancer Treatment, Cancer/Oncology, Therapeutics

Category(s): Life Sciences > Therapeutics

Developing a new mechanism-based method to treat behavioral variant frontotemporal dementia

This technology offers a novel, mechanism-based therapeutic method using oxytocin and specific compounds to treat social-affective deficits in behavioral variant frontotemporal dementia (bvFTD). Background: Behavioral variant frontotemporal dementia (bvFTD) is a prevalent form of dementia characterized by severe social and emotional impairments,...

Published: 3/30/2026 | Updated: 3/30/2026 | Inventor(s): Wei-Dong Yao

Keywords(s): dementia, electrophysiology, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

Enzymatic Protoplast Isolation Platform for Transgene-Free Genome Editing in Blueberry (Vaccinium)

Transgene-Free Protoplast Platform for Accelerated Blueberry Breeding This protoplast isolation technology employs a targeted enzymatic treatment to remove the cell wall from blueberry (Vaccinium) cells, enabling direct access to the cellular membrane for precise genetic and molecular manipulation. Precision agriculture and modern fruit breeding increasingly...

Published: 3/30/2026 | Updated: 3/30/2026 | Inventor(s): Felix Enciso Rodriguez, Patricio Munoz del Valle, Manuel Gastelbondo

Keywords(s):

Category(s): Technology Classifications > Agricultural > Plants-GMO

Rapid MALDI-TOF MS-Based Characterization of Fecal Gut Microbiome in Irritable Bowel Syndrome

Invention Description Irritable bowel syndrome (IBS) is a prevalent and multifactorial gastrointestinal disorder that affects 10-15% of the US population. Because the pathophysiology of IBS remains poorly understood, current diagnostic tools and treatments are limited, with diagnosis often relying on symptom-based assessments and exclusion of other...

Published: 3/27/2026 | Updated: 3/27/2026 | Inventor(s): Todd Sandrin, Peter Jurutka

Keywords(s):

Category(s): Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Diagnostic Assays/Devices

Low profile and compact transfer mechanism for remote controlled assembly of probes in ultra‐high vacuum and low temperature environments

STM head top plate and deposition and recovery tools. (a) STM head top transfer plate for attaching to the tools. (b) Deposition tool arms/hooks engaged with STM head transfer plate handles. (c) Deposition tool from a front and side view. (d) Recovery tool from a front and side view. Invention Summary: Scanning probe microscopy (SPM), a key...

Published: 3/27/2026 | Updated: 3/27/2026 | Inventor(s): Angela Coe, Guohong Li, Eva Andrei

Keywords(s):

Category(s): Technology Classifications > Physical Sciences & Engineering

High-Efficiency Electrospray Deposition for Sub-Plume-Scale Surfaces

Schematic of the electrospray setup. (a) Schematic and (b) photograph of an electrospray deposition experiment. White dashed lines are provided as a guide to the eye of the plume. (c) Schematic of the improved spray system and process, highlighting different enhancements (E#). In stage 1, a negative polarity spray (E1) is sprayed directly at a large...

Published: 3/27/2026 | Updated: 3/27/2026 | Inventor(s): Jonathan Singer, Sarah Park

Keywords(s): Biomaterials

Category(s): Technology Classifications > COVID-19, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Vaccine

SARS-CoV-2 Papain-Like Protease (PLpro) Inhibitors

Invention Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a global health risk despite the availability of vaccines and two oral antivirals, molnupiravir and Paxlovid. Limitations including modest efficacy, drug–drug interactions, and the emergence of resistance, particularly to nirmatrelvir, highlight...

Published: 3/27/2026 | Updated: 3/27/2026 | Inventor(s):

Keywords(s):

Category(s): Technology Classifications > COVID-19

Antiviral Compositions for Enterovirus D68 and an FP-Based Method for Validating Candidate Compounds

Invention Portfolio Summary: Enterovirus D68 (EV-D68) is an RNA virus in the Picornaviridae family, is a re-emerging pediatric pathogen associated with recurrent outbreaks, can cause severe respiratory disease, and has also been linked to acute flaccid myelitis (AFM), whose incidence has risen steadily over the past decade. There are no approved...

Published: 3/27/2026 | Updated: 3/27/2026 | Inventor(s):

Keywords(s):

Category(s): Technology Classifications > Healthcare & Life Sciences

REALM: Smarter, Faster, and More Reliable Document Re-Ranking

Workflow of recursive relevance modeling framework for LLM-based document re-ranking Invention Summary: Most Large Language Model LLM-based re-rankers produce single-point relevance scores without modeling uncertainty, even though LLM outputs are inherently stochastic. Treating these predictions as deterministic...

Published: 3/27/2026 | Updated: 3/27/2026 | Inventor(s): Pinhuan Wang, Hang Liu

Keywords(s):

Category(s): Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright

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