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Inhibition of BACH1 for pulmonary arterial hypertension therapy
LU 2024-222 INVENTORS Youyang Zhao* SHORT DESCRIPTION This invention identifies a protein called BACH1 as a key driver of pulmonary arterial hypertension (PAH). By targeting and inhibiting BACH1, particularly in the pulmonary endothelium, this technology provides methods for preventing or reversing the abnormal thickening of pulmonary vasculature,...
Published: 3/5/2026
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Inventor(s):
Keywords(s):
Cardio-Pulmonary
,
Pulmonary disease
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Development of SelU Inhibitors as New Antibiotics
Scientists discovered that special chemical modifications on bacterial tRNA help control protein production and stress responses. They have also developed novel compounds that take advantage of this mechanism to produce antibiotic effects. Background: The field of epitranscriptomics focuses on the chemical modifications of RNA molecules, which are...
Published: 3/5/2026
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Inventor(s):
Jia Sheng
,
Thomas Begley
Keywords(s):
antibiotics
,
inhibitors
,
Technologies
Category(s):
Campus > University at Albany
,
Technology Classifications > Drug Design and Synthesis
iDFax: AI-Powered Software for Healthcare Fax Management
UTHealth creators have utilized artificial intelligence (AI) to create a software tool that is integrated with existing electronic health records (EHR) systems to automate medical fax management, resulting in a 3.6x reduction in fax processing time or 60k hours compared to legacy systems. Efficiency in time and money on this task helped conserve resources...
Published: 3/4/2026
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Inventor(s):
Keywords(s):
Category(s):
Health IT
,
Software
Surgical system for minimally invasive repair of sacro-iliac luxations/fractures in dogs and cats
Executive Summary Injuries to the pelvises of cats and dogs often result in damage to the Sacro-iliac or SI joint. Traditionally, SI joint damage is repaired using an invasive operation, increasing morbidity for the patient as well as high levels of radiation exposure for the surgical team. Recently, there has been increased interest in the utilization...
Published: 3/4/2026
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Inventor(s):
Loic Dejardin
,
Kyle Snowdon
Keywords(s):
Medical
,
Surgery
Category(s):
Medical
,
Animal/Veterinary
Design, Contact Modeling, and Collision-inclusive Planning of a Dual-stiffness Aerial RoboT (DART)
Invention Description Collision-resilient quadrotors are designed to leverage impacts and perform agile maneuvers in cluttered environments; however, current models face a trade-off between two limited modes: Rigid protection and flexible adaptation. With rigid protection designs, there are safeguards that prevent damage, but they cannot deform to...
Published: 3/4/2026
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Inventor(s):
Yogesh Kumar
,
Karishma Patnaik
,
Wenlong Zhang
Keywords(s):
Category(s):
Artificial Intelligence/Machine Learning
,
Physical Science
,
Computing & Information Technology
Chimeric Inhibitors
Chimeric PARP/NAMPT inhibitors have been designed to be phosphoribosylated by NAMPT (nicotinamide phosphoribosyltransferase). This modification enriches the cytotoxic adducts held within cancer cells that overexpress NAMPT and significantly increases the safety and efficacy of PARP inhibition, minimizes resistance, and promotes further cancer cell death....
Published: 3/4/2026
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Inventor(s):
Gregory Thatcher
,
Jiqiang Fu
,
Ganga Reddy Velma
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Oncology
Engineered Gamma Delta T-Cells and Methods of Making and Using Thereof (UCLA Case No. 2020-913)
UCLA researchers in the Department of Molecular Immunology & Molecular Genetics have developed gamma delta (gd) T cell receptor gene-modified immune cells derived from stem and progenitor cells that enable scalable, off-the-shelf allogeneic cell therapies with broad therapeutic potential. BACKGROUND: Cell-based immunotherapies have demonstrated...
Published: 3/4/2026
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Inventor(s):
Lili Yang
,
Derek Lee
,
Tyler Halladay
Keywords(s):
Category(s):
Diagnostic Markers > Immunology
,
Diagnostic Markers > Cancer
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Life Science Research Tools > Cell Lines
,
Therapeutics > Oncology
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Therapeutics > CNS and Neurology
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Therapeutics > Hematology
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Therapeutics > Autoimmune
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Therapeutics > Gene Therapy And Editing
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Therapeutics > Stem Cells And Regenerative Medicine
,
Therapeutics > Infectious Diseases
Engineered Models of Human Embryo Implantation - Microfabricated Cell Culture Platforms to Increase the Efficiency and Timing of Blastoid Formation and their Lineage Representation (UCLA Case No. 2026-096)
Details available soon. Please contact UCLA Technology Development Group if you have any questions or would like more information in the meantime.
Published: 3/4/2026
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Inventor(s):
Steven Jonas
Keywords(s):
Category(s):
Therapeutics > Stem Cells And Regenerative Medicine
,
Therapeutics > Women's Health
Novel Safe Potent Precisely Attenuated Mycobacterium Tuberculosis Vaccine Against Tuberculosis (UCLA Case No. 2026-109)
Details available soon. Please contact UCLA Technology Development Group if you have any questions or would like more information in the meantime.
Published: 3/4/2026
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Inventor(s):
Marcus Horwitz
Keywords(s):
Category(s):
Therapeutics > Infectious Diseases
Gene-Modified Conventional Type 1 Dendritic Cells (UCLA Case No. 2026-093)
Details available soon. Please contact UCLA Technology Development Group if you have any questions or would like more information in the meantime.
Published: 3/4/2026
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Inventor(s):
Steven Dubinett
Keywords(s):
Category(s):
Therapeutics > Immunology And Immunotherapy
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