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Rapid MALDI-TOF MS-Based Characterization of Fecal Gut Microbiome in Irritable Bowel Syndrome
Invention Description Irritable bowel syndrome (IBS) is a prevalent and multifactorial gastrointestinal disorder that affects 10-15% of the US population. Because the pathophysiology of IBS remains poorly understood, current diagnostic tools and treatments are limited, with diagnosis often relying on symptom-based assessments and exclusion of other...
Published: 3/27/2026
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Updated: 3/27/2026
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Inventor(s):
Todd Sandrin
,
Peter Jurutka
Keywords(s):
Category(s):
Life Science (All LS Techs)
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Proteomic Assays/Reagents/Tools
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Diagnostic Assays/Devices
Low profile and compact transfer mechanism for remote controlled assembly of probes in ultra‐high vacuum and low temperature environments
STM head top plate and deposition and recovery tools. (a) STM head top transfer plate for attaching to the tools. (b) Deposition tool arms/hooks engaged with STM head transfer plate handles. (c) Deposition tool from a front and side view. (d) Recovery tool from a front and side view. Invention Summary: Scanning probe microscopy (SPM), a key...
Published: 3/27/2026
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Updated: 3/27/2026
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Inventor(s):
Angela Coe
,
Guohong Li
,
Eva Andrei
Keywords(s):
Category(s):
Technology Classifications > Physical Sciences & Engineering
High-Efficiency Electrospray Deposition for Sub-Plume-Scale Surfaces
Schematic of the electrospray setup. (a) Schematic and (b) photograph of an electrospray deposition experiment. White dashed lines are provided as a guide to the eye of the plume. (c) Schematic of the improved spray system and process, highlighting different enhancements (E#). In stage 1, a negative polarity spray (E1) is sprayed directly at a large...
Published: 3/27/2026
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Updated: 3/27/2026
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Inventor(s):
Jonathan Singer
,
Sarah Park
Keywords(s):
Biomaterials
Category(s):
Technology Classifications > COVID-19
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Technology Classifications > Physical Sciences & Engineering
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Technology Classifications > Medical Devices
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Technology Classifications > Vaccine
SARS-CoV-2 Papain-Like Protease (PLpro) Inhibitors
Invention Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a global health risk despite the availability of vaccines and two oral antivirals, molnupiravir and Paxlovid. Limitations including modest efficacy, drug–drug interactions, and the emergence of resistance, particularly to nirmatrelvir, highlight...
Published: 3/27/2026
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Updated: 3/27/2026
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Inventor(s):
Keywords(s):
Category(s):
Technology Classifications > COVID-19
Antiviral Compositions for Enterovirus D68 and an FP-Based Method for Validating Candidate Compounds
Invention Portfolio Summary: Enterovirus D68 (EV-D68) is an RNA virus in the Picornaviridae family, is a re-emerging pediatric pathogen associated with recurrent outbreaks, can cause severe respiratory disease, and has also been linked to acute flaccid myelitis (AFM), whose incidence has risen steadily over the past decade. There are no approved...
Published: 3/27/2026
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Updated: 3/27/2026
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Inventor(s):
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
REALM: Smarter, Faster, and More Reliable Document Re-Ranking
Workflow of recursive relevance modeling framework for LLM-based document re-ranking Invention Summary: Most Large Language Model LLM-based re-rankers produce single-point relevance scores without modeling uncertainty, even though LLM outputs are inherently stochastic. Treating these predictions as deterministic...
Published: 3/27/2026
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Updated: 3/27/2026
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Inventor(s):
Pinhuan Wang
,
Hang Liu
Keywords(s):
Category(s):
Technology Classifications > Software & Algorithms
,
Technology Classifications > Software & Copyright
Non-Invasive Closed-Loop Diaphragmatic Pacer for SUDEP Prevention
Invention Summary: Epileptic seizures can cause central respiratory arrest, a phenomenon called Sudden Unexpected Death in Epilepsy (SUDEP) which needs immediate respiratory support within 3 minutes to avoid death. The absence of reliable biomarkers further limits preventive measures to avoid SUDEP. Here, a wearable diaphragmatic pacer that...
Published: 3/27/2026
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Updated: 3/27/2026
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Inventor(s):
Benton Purnell
,
Detlev Boison
,
Simiao Niu
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Medical Devices
Entropy-based Method for Multi-Physics Optimization of Additively Manufactured Cellular Material
Invention Description The advancements in additive manufacturing (AM) have enabled the creation of complex, architected cellular materials (metamaterials) with extraordinary properties, surpassing traditional manufacturing capabilities. These materials offer significant improvements in weight reduction, thermal-fluid efficiency, and mechanical strength,...
Published: 3/26/2026
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Updated: 3/26/2026
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Inventor(s):
Tyler Smith
,
Dhruv Bhate
Keywords(s):
Category(s):
Advanced Materials/Nanotechnology
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Manufacturing/Construction/Mechanical
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Physical Science
Compounds and Methods for Inducing UCP1 Expression (UCLA Case No. 2019-272)
Contact UCLA Technology Development Group for more information. Keywords: Mitochondria, PKA, AKAP, adipocytes, UCP1, high-throughput screen, lipolysis, obesity
Published: 3/26/2026
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Updated: 3/26/2026
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Inventor(s):
Laurent Vergnes
,
Karen Reue
Keywords(s):
Category(s):
Therapeutics > Metabolism And Endocrinology
Novel Lipid Lowering, Anti-Atherosclerosis and Anti-Obesity Effects of Netrin-1 (UCLA Case No. 2019-728)
UCLA researchers in the Department of Anesthesiology have developed a novel and extremely robust lipid lowering, anti-atherosclerotic, and anti-obesity treatment with Netrin-1.BACKGROUND:Hyperlipidemia, an elevation of different forms of lipids in the bloodstream, is the most important risk factor for coronary heart disease, while causing many other...
Published: 3/26/2026
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Updated: 3/26/2026
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Inventor(s):
Hua Cai
Keywords(s):
Cardiovascular
,
Hematology
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Therapeutics & Vaccines
Category(s):
Therapeutics > Cardiovascular
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Therapeutics > Hematology
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