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Polyamine-Based Therapeutic Approach for Alopecia Areata
Executive Summary: Oral administration of DFMO (Eflornithine), a polyamine inhibitor, offers a novel treatment to reduce elevated polyamine levels and stimulate hair regrowth in alopecia areata patients. Description: Alopecia areata is an autoimmune hair loss disorder that affects approximately 5 million patients in the United States. Laboratory...
Published: 4/17/2026
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Updated: 4/17/2026
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Inventor(s):
Andre Bachmann
,
Caleb Bupp
Keywords(s):
Category(s):
Medical
,
Pharmaceutical
,
Therapeutic
Small Molecule Inhibitors of Pleckstrin-2 for Treating Myeloproliferative Neoplasms
SHORT DESCRIPTION Small molecule inhibitors of Pleckstrin-2 (Plek2) for treating cell proliferative diseases and disorders, particularly myeloproliferative neoplasms (MPNs). NU Tech IDs: NU 2018-169, NU 2021-005 PRINCIPAL INVESTIGATOR Peng Ji Northwestern University Feinberg School of Medicine, Department of Pathology IP...
Published: 4/16/2026
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Updated: 4/16/2026
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Inventor(s):
Keywords(s):
Breast cancer
,
Cancer/Oncology
,
Colon cancer
,
Leukemia
,
Lung cancer
,
Pancreatic cancer
,
Small molecule
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
AI-driven Analog-to-Digital Converter (ADC) Design Automation
Invention Description Designing high-performance analog circuits, such as analog-to-digital converters (ADCs), is a complex and time-intensive process that typically requires significant expert knowledge and manual tuning. Traditional design methods rely heavily on iterative trial-and-error, making it difficult to efficiently meet strict performance...
Published: 4/16/2026
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Updated: 4/16/2026
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Inventor(s):
Arindam Sanyal
,
Imon Banerjee
,
Zuwei Guo
,
Shamma Nasrin
Keywords(s):
Category(s):
Manufacturing/Construction/Mechanical
,
Physical Science
,
Semiconductors, Materials & Processes
,
Semiconductor Devices
Benzofuranoindoline-Containing Fungal RiPP-Derived Anticancer Compounds
Benzofuranoindoline-containing fungal RiPP-derived compounds and analogs, plus pharmaceutical compositions, and administration methods for treating cancers, including leukemia. Problem: The disclosure targets diseases and disorders where new therapeutic compounds are needed, including cancers such as leukemia. Fungal ribosomally synthesized and post-translationally...
Published: 4/16/2026
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Updated: 4/16/2026
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Inventor(s):
Xue Sherry Gao
,
Hans Renata
,
Qiuyue Nie
Keywords(s):
Oncology
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Integrated Chemical-Looping System for High-Purity Hydrogen Generation
Delivers On-Site Methane-Derived Hydrogen While Simultaneously Supplying CO and N2, Eliminating External Oxygen-Separation and Heating This integrated chemical-looping system delivers on-site methane-derived hydrogen and simultaneously supplies pure CO and N2, eliminating the need for external oxygen separation or downstream separations and external...
Published: 4/16/2026
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Updated: 4/16/2026
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Inventor(s):
Jonathan Scheffe
,
Kathryn Trimm
Keywords(s):
Category(s):
Technology Classifications > Engineering > Chemical
,
Technology Classifications > Engineering > Materials
Polymers of Intrinsic Microporosity for Improved Smart Device and Display Technologies
Electrochromic Devices Rapidly Changing Color for Supercapacitive and Pseudocapacitive Energy Storage These polymers of intrinsic microporosity (PIMs) use electrochromic materials that change color in response to an applied voltage for improved energy storage. Electrochromic materials switch color when a voltage potential is applied. These materials...
Published: 4/16/2026
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Updated: 4/16/2026
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Inventor(s):
Austin Evans
,
Mahmudul Hasan
,
Rupam Roy
,
Kiana Treaster
,
Kaitlin Slicker
,
Ani Davis
,
Dibakar Das
Keywords(s):
Category(s):
Technology Classifications > Engineering > Chemical
,
Technology Classifications > Engineering > Materials
Smart Onsite Black Water Purification System for Water and Nutrient Recycling
Reuses Wastewater, Enabling the Near-Perpetual Reuse of the Same Volume of Water This blackwater purification system reuses wastewater to enable the near-perpetual reuse of the same water volume, generating reusable wastewater. Worldwide, sanitation systems primarily rely on centralized wastewater and sewage treatment plants, with onsite septic systems...
Published: 4/16/2026
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Updated: 4/16/2026
|
Inventor(s):
Nawari Nawari
,
Heidemarie Wittmann
,
Michael Volk
Keywords(s):
Category(s):
Technology Classifications > Engineering > Mechanical
,
Technology Classifications > Others > Cleantech
Methods To Regulate Metabolism For Treatment Of Neural Injuries and Neurodegeneration
Description of Technology: Axonal injury and subsequent neuronal death underpin the pathology of many neurological disorders from acute neural injuries (motor vehicle crashes, combat related injuries, traumatic brain injuries) to neurological diseases (multiple sclerosis, glaucoma). In the central nervous system (CNS), microglia help respond to CNS...
Published: 4/16/2026
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Updated: 4/16/2026
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Inventor(s):
Wei Li
,
Jingxing Ou
,
Tantai Zhao
Keywords(s):
Category(s):
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Ear, Nose, & Throat
,
TherapeuticArea > Neurology
,
Collaboration Sought > Licensing
Ultra-Smooth Single-Crystal Diamond Surfaces for Enhanced Device Performance
Reduces Surface Roughness and Spike Density Through Extended UV-Ozone Exposure This diamond smoothing method via extended UV-ozone exposure enhances device performance and reliability by reducing surface roughness and spike density. Diamond-based devices, such as rectifiers, offer significant potential for high-power and high-frequency applications....
Published: 4/16/2026
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Updated: 4/16/2026
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Inventor(s):
Fan Ren
,
Chao-Ching Chiang
,
Stephen Pearton
Keywords(s):
Category(s):
Technology Classifications > Engineering > Chemical
,
Technology Classifications > Engineering > Electrical
,
Technology Classifications > Engineering
,
Technology Classifications > Engineering > Materials
Thermal Depolymerization Etching of Microphase Separations for Creating High-Surface-Area Polymers
Enables Rapid, Solvent-Free Formation of Mesoporous Materials by Selectively Removing Methacrylate Domains Thermal depolymerization etching enables rapid, solvent-free formation of high-surface-area mesoporous polymers by selectively removing methacrylate domains. Etching approaches are used to generate nanoscale porosity in polymers. However, existing...
Published: 4/16/2026
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Updated: 4/16/2026
|
Inventor(s):
Brent Sumerlin
,
Kaden Stevens
,
James Young
,
Jared Bowman
,
Megan Lott
,
Cabell Eades
Keywords(s):
Category(s):
Technology Classifications > Engineering > Chemical
,
Technology Classifications > Engineering > Electrical
,
Technology Classifications > Engineering > Materials
,
Technology Classifications > Others > Cleantech
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