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A Novel Chemical Modification of PROTACs (Proteolysis Targeting Chimeras) to Increase Selectivity in Hypoxic Environments (UCLA Case No. 2024-094)
UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel chemical modification of PROTACs to increase their selectivity under hypoxic conditions. BACKGROUND: Proteolysis targeting chimeras (PROTACs) are molecules that induce targeted degradation of proteins by recruiting a ubiquitin ligase to a protein of interest...
Published: 3/18/2026
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Updated: 3/18/2026
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Inventor(s):
Stuart Conway
Keywords(s):
Category(s):
Chemical > Synthesis
,
Therapeutics > Oncology
Targeted Protein Degradation in Cancer via Hypoxia-Activated PROTACs and Molecular Glues (UCLA Case No. 2024-095)
UCLA researchers from the Department of Molecular and Medical Pharmacology have developed a dual small-molecule platform for targeted protein degradation in cancer. By combining hypoxia-activated PROTACs with rationally designed molecular glues, this approach addresses key limitations in tumor selectivity. BACKGROUND: Despite major advances in cancer...
Published: 3/18/2026
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Updated: 3/18/2026
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Inventor(s):
Stuart Conway
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology (Small Molecules)
Furanic Quaternary Ammonium Salt Antibacterial Compounds
This technology describes novel quaternary ammonium salt compounds with antibacterial properties and their methods of making. Background Increased resistance to current antibiotics and QAS compounds exhibited by bacteria requires the discovery and production of new formulations. Moreover, the replacement of the benzyl functionality of traditional...
Published: 3/18/2026
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Updated: 3/18/2026
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Inventor(s):
Konstantinos Goulas
Keywords(s):
Category(s):
Chemical
,
Chemistry
CRoP: Adaptive Pruning for Personalized and Robust Static Human-Sensing Using Pre-Trained Models
Invention Description Personalized human-sensing systems, especially in clinical and health applications, often struggle with limited user-specific data and significant variability between individuals. Differences in physiology, behavior, and environmental conditions can cause performance drops when models trained on general datasets are applied to...
Published: 3/18/2026
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Updated: 3/18/2026
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Inventor(s):
Asif Salekin
Keywords(s):
Category(s):
Artificial Intelligence/Machine Learning
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Computing & Information Technology
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Life Science (All LS Techs)
,
Medical Diagnostics/Sensors
Polymerase-Theta Inhibition for Treating Epstein-Barr Virus (EBV) Cancers and Related Diseases
Proteolysis Targeting Chimeras (PROTACs) Block Microhomology or Theta-Mediated End Joining in Cancer Cells These polymerase theta inhibitors treat Epstein-Barr virus (EBV)-associated cancers and related diseases. EBV cancers are linked to two percent of the global cancer burden and are difficult to treat, demonstrating a strong need for effective...
Published: 3/18/2026
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Updated: 3/18/2026
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Inventor(s):
Sumita Bhaduri-McIntosh
,
Michael McIntosh
,
Guangrong Zheng
,
Hui Chen
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
Self-delivery USP10 siRNA to promote regenerative healing-new IP
This technology employs an engineered self-delivering siRNA to selectively reduce USP10 protein levels in tissues, thereby promoting regenerative healing and suppressing pathological scarring. Preclinical studies in the eye demonstrate a favorable safety profile and robust efficacy, supporting the potential of this approach for treating fibrotic disease...
Published: 3/18/2026
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Updated: 3/18/2026
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Inventor(s):
Audrey Bernstein
,
Sean McCauley
,
Alexey Wolfson
,
Tere Williams
Keywords(s):
fibrosis
,
opthalmology
,
scarring
,
siRNA
,
skin diseases
,
Technologies
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Technology Classifications > Healthcare
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Campus > Upstate Medical University
Nanomaterial Printhead for Additive Manufacturing
This printhead can deposit reactive materials as they are generated in real time Background The ability to integrate multifunctional parameters into one material has crosscutting impacts in several applications. For example, one can engineer and modify structural materials that provide high mechanical strength at various length scales to attain...
Published: 3/18/2026
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Updated: 3/18/2026
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Inventor(s):
Chih-hung Chang
,
Brian Paul
,
Yujuan He
Keywords(s):
Category(s):
Engineering
,
Nanoscience & Microtechnologies
Membrane-less, Gravity Independent Liquid-Liquid and Gas-Liquid Extraction and Phase Separation
A membrane-less device enabling liquid-liquid and gas-liquid separation without requiring gravity Background The separation of mixtures of fluid phases, particularly liquid-liquid and gas-liquid extraction, is relevant to many industrial chemical and biochemical processes, including fuels production, pharmaceuticals, and hydrometallurgy. Many solvent...
Published: 3/18/2026
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Updated: 3/18/2026
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Inventor(s):
Goran Jovanovic
,
Matthew Coblyn
,
Jad Touma
,
Lucas Freiberg
,
Francis Chukwunta
,
Lei Li
,
Cliff Kowall
,
Bingchen Wang
,
Yihan Song
,
Fan Yang
,
Aigerim Baimoldina
Keywords(s):
Category(s):
Engineering
INDUSTRIAL LASER PULSE METROLOGY
VAlue proposition The present technology is a method and apparatus for measuring the performance of industrial ultrashort‑pulse, diode‑pumped lasers. While these lasers are widely used in high‑power, high‑repetition‑rate applications, users have observed that systems with identical published specifications often deliver very different processing...
Published: 3/18/2026
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Updated: 3/18/2026
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Inventor(s):
Marcos Dantus
Keywords(s):
Category(s):
Analytical Instruments
,
Photonics
,
Test and Measurement
Perceptive catheter system for thrombus retrieval and aneurysm embolization
Summary During catheter-based treatments, surgeons are hampered by the limited sensory awareness of microcatheters as they move through small, fragile, and mobile blood vessels. This lack of perception leads to a success rate of 25% in achieving complete reperfusion in a single attempt. The proposed system provides quantitative feedback on distance...
Published: 3/17/2026
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Updated: 3/17/2026
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Inventor(s):
Keywords(s):
Category(s):
Medical Devices
,
Robotics
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