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A Novel, Human-Derived HER2 Antibody for Cancer Therapeutics and Diagnostics
ADDRESSED NEED The HER2 protein is overexpressed in 20-30% of breast cancers and is a well-established treatment target. While HER2-targeted antibodies have proven effective cancer therapies, those currently on the market are derived from non-human sources and routinely elicit adverse immune responses. This technology directly addresses this challenge...
Published: 1/13/2026   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostics, Therapeutics
Strategic Design of Drive and Sense Electrodes for a Resonant MEMS Device and a Resonant MEMS Array
Advantages Enhances target resonance performance without complex electrode reshaping or fabrication changes Suppresses spurious vibration modes to improve signal clarity and device reliability Compatible with existing MEMS processes, reducing redesign time and manufacturing risk Applicable across multiple MEMS materials, geometries, frequencies,...
Published: 1/13/2026   |   Inventor(s): Ugur Guneroglu, Adnan Zaman, Jing Wang
Keywords(s):  
Category(s): Technology Classifications > Electronics, Technology Classifications > Electronics > Electronics Sensors, Technology Classifications > Electronics > Electronics Telecommunications, Technology Classifications > Engineering > Electrical Engineering
An Acoustic Device for Large Area Single Cell Trapping and Selective Release (Case No. 2025-047)
Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed an acoustic microfluidic platform that offers a cost-effective and practical approach for handling individual cells at the microscale. Background: Single-cell manipulation is essential for understanding cellular behavior, disease progression, and therapeutic...
Published: 1/13/2026   |   Inventor(s): Pei-Yu Chiou, Xiang Zhang
Keywords(s): acoustic microfluidics, acoustic potential wells, acoustics, cell proliferation, cell viability, Diagnostic Platform Technologies (E.G. Microfluidics), diagnostic platforms, Digital Microfluidics, disposable microfluidic platforms, high throughput, high throughput assays, high throughput testing, High-Content Screening, high-throughput cell handling, low-cost fabrication, MEMS, MEMS metasurface, micro-electromechanical systems (MEMS), Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared laser, photolithography-free fabrication, research instrumentation, scalable platform, single cell analysis, single cell analysis and testing, Single cell data, single-cell handling, single-cell manipulation, single-cell resolution, single-cell trapping
Category(s): Chemical, Chemical > Chemical Processing & Manufacturing, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Mechanical, Mechanical > Instrumentation, Platforms, Platforms > Diagnostic Platform Technologies
REMOVING CONTAMINANTS FROM A FLUID
VAlue proposition Per- and polyfluoroalkyl substances (PFASs) are manmade chemicals used in various industrial and consumer products such as firefighting foams, household cleaners, and vapor suppressants. They have a unique property in being able to repel both oil and water due to their hydrophilic and hydrophobic components. While there are hundreds...
Published: 1/13/2026   |   Inventor(s): Thomas Schuelke, Mary Ensch, Michael Becker, Cory Rusinek
Keywords(s):  
Category(s): Environmental, Advanced Materials
FLEXIBLE SENSOR
VAlue proposition Inflatable structures provide significant volume and weight savings for future space and soft robotic applications. Structural health monitoring of these structures is essential for safe operation, providing early warnings of damage, and measuring structural changes over time. An approach is desired for a single flexible strain...
Published: 1/13/2026   |   Inventor(s): Xiaobo Tan, Mohammed Al-Rubaiai
Keywords(s):  
Category(s): Test and Measurement
INSPECTION OF INTERNAL SURFACE OF CYLINDRICAL STRUCTURES
VAlue proposition Surface defect inspection, detection, and classification in hollow cylindrical surfaces such as pipes and barrels have a significant impact on the structural integrity of various industrial products. Regular inspection and identification of the faults reduces the likelihood of faults’ aggravation, limits the damaging effects,...
Published: 1/13/2026   |   Inventor(s): Yiming Deng, Mohand Alzuhiri
Keywords(s):  
Category(s): Test and Measurement, Data Processing/Analysis, Photonics
Peri-Operative Cancer Therapy to Preserve Anti-Tumor Immune Surveillance (UCLA Case No. 2025-257)
UCLA Researchers from the Department of Surgery have developed a novel approach to preserve anti-tumor immunity in the peri-operative period through modulation of clinically relevant molecular and cellular targets. BACKGROUND: Surgical resection with curative intent is a mainstay of treatment for many solid tumors. However, even when the tumor is macroscopically...
Published: 1/12/2026   |   Inventor(s): Tyler McCaw
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Computational Method to Identify Protein Hotspots and Allosteric Sites
Invention Description Protein allostery is important in many biological processes and drug development. Understanding the mechanisms involved would be highly beneficial for therapeutic interventions. Existing techniques focus primarily on equilibrium dynamics and network analysis for allosteric interaction mapping. Unfortunately, these are limited...
Published: 1/12/2026   |   Inventor(s): Paul Campitelli, Tushar Modi, Sefika Banu Ozkan
Keywords(s):  
Category(s): Vaccines/Antimicrobials, Proteomic Assays/Reagents/Tools, Life Science (All LS Techs), Computing & Information Technology, Artificial Intelligence/Machine Learning
Computational Method to Identify Mutational Epistasis in Proteins
Invention Description Viral evolution, particularly rapid viral evolution, can lead to the emergence of variants of concern. In order to develop effective antiviral strategies, it is essential to understand the molecular mechanisms driving these adaptations. Some research has focused on identifying adaptive mutations and how they impact protein structure...
Published: 1/12/2026   |   Inventor(s): Paul Campitelli, Nicholas Ose, Tushar Modi, Ismail Can Kazan, Sefika Banu Ozkan
Keywords(s):  
Category(s): Vaccines/Antimicrobials, Life Science (All LS Techs), Computing & Information Technology, Artificial Intelligence/Machine Learning, COVID-19, SARS-CoV-2, Coronavirus
User-Actuated Valve Actuator for Microfluidic Devices
Invention Description Lab-on-a-chip technology and microfluidic diagnostic devices often rely on complex mechanical or electrical systems to manipulate fluid, making them costly and bulky. These components may limit portability, decrease operational lifetime, and prevent widespread use by untrained personnel or patients at the point of care or at home....
Published: 1/12/2026   |   Inventor(s): Clifford Anderson, Vi Nguyen, Jennifer Blain Christen
Keywords(s): Analytical Devices, Bioassay, Biosensor, Fluid, Micro-Fluidics
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Point of Care
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