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Retinoic Acid Agonists for Attenuation of Doxorubicin-Induced Cardiotoxicity

SHORT DESCRIPTION A method for preventing cardiotoxicity in patients undergoing anthracycline-based chemotherapy using retinoic acid receptor gamma (RARG) agonists. INVENTORS Paul W Burridge*, PhD Associate Professor, Pharmacology, Northwestern University Feinberg School of Medicine * Principal Investigator NU...

Published: 2/6/2026 | Inventor(s):

Keywords(s): Cancer Treatment, Cancer/Oncology, Cardiology and Cardiovascular disease, Chemotherapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Extracellular vesicles for diagnosis and treatment of breast cancer

SHORT DESCRIPTION Novel methods for detecting cancer through exosome analysis and bioengineered exosomes specifically designed to target cancer stem cells (CSCs). INVENTORS Huiping Liu*, MD, PhD Associate Professor, Pharmacology, Medicine (Hematology and Oncology), Northwestern University Feinberg School...

Published: 2/6/2026 | Inventor(s):

Keywords(s): Biomarker, Breast cancer, Cancer/Oncology, Diagnostics, Imaging, Research tool

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools

3D Clinostat with Incorporated Fluid Flow for Biological Experiments

Simulates Microgravity and Vascular Flow, Enabling Next-Generation Biological and Industrial Research This 3D clinostat uniquely integrates on-board or external fluid flow, enabling simultaneous simulation of microgravity and controlled shear stress. 3D clinostat systems are useful as microgravity simulation devices. However, fluid flow capabilities...

Published: 2/6/2026 | Inventor(s): Josephine Allen, Christopher Ludtka

Keywords(s):

Category(s): Technology Classifications > Engineering > Materials, Technology Classifications > Medical Devices > Equipment

Gradient Porosity Electrodes for Li-Ion Batteries

Schematic representing porosity of each layer in a laminated LCO electrode (beige curvy lines represent the electrode’s porosity). Invention Summary: There is a pressing need to increase the specific energy of Li-ion batteries to increase range of electric vehicles and decrease cost of the battery. In theory, increasing the thickness...

Published: 2/6/2026 | Inventor(s): Glenn Amatucci, Emily Sukenik

Keywords(s):

Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Energy & Battery

Generation of a single-chain recombinant IgA1 isotype antibody compatible with in vivo nucleic acid delivery for the treatment and prevention of flavivirus infection

This technology uses a single-chain IgA1 antibody delivered by DNA or RNA to enable the body to produce its own protection against dengue and Zika viruses, offering rapid, safe, and scalable prevention and treatment without risk of antibody-dependent enhancement. Background: Flavivirus infections, including those caused by dengue and Zika viruses,...

Published: 2/6/2026 | Inventor(s): Adam Waickman, Stephen Thomas

Keywords(s): antibody therapy, infectious diseases, nucleic acid, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare

Use of recombinant IgA1 isotype mAbs to prevent and antagonize transplacental transmission of flaviviruses in pregnant women

This technology is a single-chain IgA1 antibody delivered by DNA or RNA, enabling the body to produce its own dengue-neutralizing antibodies safely and quickly, without the risk of worsening infection, for rapid prevention and treatment of flavivirus diseases. Background: The field of flavivirus therapeutics, particularly for diseases like dengue,...

Published: 2/6/2026 | Inventor(s): Adam Waickman, Stephen Thomas

Keywords(s): infectious diseases, monoclonal antibodies, pregnancy, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare

DEVICE FOR ORAL FLUID COLLECTION CONSISTING OF ABSORBANT MATERIAL AND NESTED TUBES REQUIRING CENTRIFUGATION

This is a simple, low-cost device using absorbent material and nested tubes to collect clean, mucous-free oral fluid samples by centrifugation, making sample collection easier, more hygienic, and affordable for labs and research. Background: Oral fluid collection is an essential process in various fields, including clinical diagnostics, biomedical...

Published: 2/6/2026 | Inventor(s): Aaron Glass

Keywords(s): saliva, Salivary biomarkers, specimen collection, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics

Indole-3-Propionic Acid (IPA) Protects Against Heart Failure with Preserved Ejection Fraction (HFpEF) (UCLA Case No. 2022-142)

UCLA researchers in Department of Medicine, Division of Cardiology have identified the protective effects of gut-heart crosstalk mediated by 3-propionic acid (IPA) in the progression of heart failure with preserved ejection fraction (HFpEF). IPA supplementation could rescue the IPA deficiency associated heart defects, protect against heart malfunction,...

Published: 2/5/2026 | Inventor(s): Aldons Lusis, Yang Cao

Keywords(s):

Category(s): Therapeutics > Cardiovascular

Coagulation Factor XI (FXI) Functional Roles and Regulation for Treatment of Heart Failure (UCLA Case No. 2022-141)

UCLA researchers from the Department of Medicine have discovered a novel therapeutic target (between the interaction of the heart and liver) to treat heart failure with preserved ejection fraction (HFpEF), which afflicts approximately half of all patients with heart failure. Contact UCLA Technology Development Group for more information. Related papers...

Published: 2/5/2026 | Inventor(s): Aldons Lusis

Keywords(s):

Category(s): Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology

Microfluidic Lab-on-Chip Device, Small Molecules and Three-Dimensional Spheroids for Cell Reprogramming (UCLA Case No. 2020-881)

UCLA researchers in the Department of Bioengineering at David Geffen School of Medicine developed a microfluidic device that can significantly promote cell reprogramming and direct induced neuronal reprogramming with high specificity. This invention is important for basic science, disease modeling, therapeutic testing, functionalizing knowledge for...

Published: 2/5/2026 | Inventor(s): Song Li, Yang Song

Keywords(s):

Category(s): Life Science Research Tools > Microfluidics And Mems

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